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BRF2 (BRF2 RNA polymerase III transcription initiation factor subunit)

Identity

Alias (NCBI)BRFU
TFIIIB50
HGNC (Hugo) BRF2
HGNC Alias symbFLJ11052
BRFU
TFIIIB50
HGNC Previous nameBRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
LocusID (NCBI) 55290
Atlas_Id 50599
Location 8p11.23  [Link to chromosome band 8p11]
Location_base_pair Starts at 37843268 and ends at 37849861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RBMX (Xq26.3) / BRF2 (8p11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)BRF2   17298
Cards
Entrez_Gene (NCBI)BRF2    BRF2 RNA polymerase III transcription initiation factor subunit
AliasesBRFU; TFIIIB50
GeneCards (Weizmann)BRF2
Ensembl hg19 (Hinxton)ENSG00000104221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104221 [Gene_View]  ENSG00000104221 [Sequence]  chr8:37843268-37849861 [Contig_View]  BRF2 [Vega]
ICGC DataPortalENSG00000104221
TCGA cBioPortalBRF2
AceView (NCBI)BRF2
Genatlas (Paris)BRF2
SOURCE (Princeton)BRF2
Genetics Home Reference (NIH)BRF2
Genomic and cartography
GoldenPath hg38 (UCSC)BRF2  -     chr8:37843268-37849861 -  8p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRF2  -     8p11.23   [Description]    (hg19-Feb_2009)
GoldenPathBRF2 - 8p11.23 [CytoView hg19]  BRF2 - 8p11.23 [CytoView hg38]
ImmunoBaseENSG00000104221
Genome Data Viewer NCBIBRF2 [Mapview hg19]  
OMIM607013   
Gene and transcription
Genbank (Entrez)AA496239 AF130058 AF206673 AF298153 AK001914
RefSeq transcript (Entrez)NM_018310
Consensus coding sequences : CCDS (NCBI)BRF2
Gene ExpressionBRF2 [ NCBI-GEO ]   BRF2 [ EBI - ARRAY_EXPRESS ]   BRF2 [ SEEK ]   BRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)BRF2 [ Firebrowse - Broad ]
GenevisibleExpression of BRF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55290
GTEX Portal (Tissue expression)BRF2
Human Protein AtlasENSG00000104221-BRF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAW0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAW0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAW0
PhosPhoSitePlusQ9HAW0
Domaine pattern : Prosite (Expaxy)ZF_TFIIB (PS51134)   
Domains : Interpro (EBI)Cyclin-like_sf    TFIIB    Znf_TFIIB   
Domain families : Pfam (Sanger)TF_Zn_Ribbon (PF08271)   
Domain families : Pfam (NCBI)pfam08271   
Conserved Domain (NCBI)BRF2
PDB (RSDB)4ROC    4ROD    4ROE    5N9G   
PDB Europe4ROC    4ROD    4ROE    5N9G   
PDB (PDBSum)4ROC    4ROD    4ROE    5N9G   
PDB (IMB)4ROC    4ROD    4ROE    5N9G   
Structural Biology KnowledgeBase4ROC    4ROD    4ROE    5N9G   
SCOP (Structural Classification of Proteins)4ROC    4ROD    4ROE    5N9G   
CATH (Classification of proteins structures)4ROC    4ROD    4ROE    5N9G   
SuperfamilyQ9HAW0
AlphaFold pdb e-kbQ9HAW0   
Human Protein Atlas [tissue]ENSG00000104221-BRF2 [tissue]
HPRD06115
Protein Interaction databases
DIP (DOE-UCLA)Q9HAW0
IntAct (EBI)Q9HAW0
BioGRIDBRF2
STRING (EMBL)BRF2
ZODIACBRF2
Ontologies - Pathways
QuickGOQ9HAW0
Ontology : AmiGOtranscription factor TFIIIB complex  RNA polymerase III type 3 promoter sequence-specific DNA binding  nucleus  nucleoplasm  DNA-templated transcription, initiation  regulation of transcription by RNA polymerase III  TBP-class protein binding  cellular response to oxidative stress  metal ion binding  transcription preinitiation complex assembly  transcription preinitiation complex  
Ontology : EGO-EBItranscription factor TFIIIB complex  RNA polymerase III type 3 promoter sequence-specific DNA binding  nucleus  nucleoplasm  DNA-templated transcription, initiation  regulation of transcription by RNA polymerase III  TBP-class protein binding  cellular response to oxidative stress  metal ion binding  transcription preinitiation complex assembly  transcription preinitiation complex  
NDEx NetworkBRF2
Atlas of Cancer Signalling NetworkBRF2
Wikipedia pathwaysBRF2
Orthology - Evolution
OrthoDB55290
GeneTree (enSembl)ENSG00000104221
Phylogenetic Trees/Animal Genes : TreeFamBRF2
Homologs : HomoloGeneBRF2
Homology/Alignments : Family Browser (UCSC)BRF2
Gene fusions - Rearrangements
Fusion : QuiverBRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRF2
dbVarBRF2
ClinVarBRF2
MonarchBRF2
1000_GenomesBRF2 
Exome Variant ServerBRF2
GNOMAD BrowserENSG00000104221
Varsome BrowserBRF2
ACMGBRF2 variants
VarityQ9HAW0
Genomic Variants (DGV)BRF2 [DGVbeta]
DECIPHERBRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRF2 
Mutations
ICGC Data PortalBRF2 
TCGA Data PortalBRF2 
Broad Tumor PortalBRF2
OASIS PortalBRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBRF2
Mutations and Diseases : HGMDBRF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaBRF2
DgiDB (Drug Gene Interaction Database)BRF2
DoCM (Curated mutations)BRF2
CIViC (Clinical Interpretations of Variants in Cancer)BRF2
Cancer3DBRF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607013   
Orphanet
DisGeNETBRF2
MedgenBRF2
Genetic Testing Registry BRF2
NextProtQ9HAW0 [Medical]
GENETestsBRF2
Target ValidationBRF2
Huge Navigator BRF2 [HugePedia]
ClinGenBRF2
Clinical trials, drugs, therapy
MyCancerGenomeBRF2
Protein Interactions : CTDBRF2
Pharm GKB GenePA164741329
PharosQ9HAW0
Clinical trialBRF2
Miscellaneous
canSAR (ICR)BRF2
HarmonizomeBRF2
DataMed IndexBRF2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:01:27 CEST 2021

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