BRINP1 (BMP/retinoic acid inducible neural specific 1)

2013-08-01  

Identity

HGNC
BRINP1
LOCATION
9q33.1
LOCUSID
1620
ALIAS
DBC1,DBCCR1,FAM5A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1620
MIM: 602865
HGNC: 2687
Ensembl: ENSG00000078725

Variants:

dbSNP: 1620
ClinVar: 1620
TCGA: ENSG00000078725
COSMIC: BRINP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078725ENST00000265922O60477
ENSG00000078725ENST00000373964O60477

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
210568972011Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.70
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
224659532012Regulation of SIRT1 activity by genotoxic stress.38
198345032009Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.26
157461512005Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.25
233983162013DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα.19
195062192009Risk alleles for multiple sclerosis in multiplex families.18
233498632013The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response.17
182640852008Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms.12
124420022002Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors.10

Citation

Dessen P

BRINP1 (BMP/retinoic acid inducible neural specific 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53726/brinp1