BRSK1 (BR serine/threonine kinase 1)

2006-10-01  

Identity

HGNC
BRSK1
LOCATION
19q13.42
LOCUSID
84446
ALIAS
hSAD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84446
MIM: 609235
HGNC: 18994
Ensembl: ENSG00000160469

Variants:

dbSNP: 84446
ClinVar: 84446
TCGA: ENSG00000160469
COSMIC: BRSK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160469ENST00000309383Q8TDC3
ENSG00000160469ENST00000326848J3KNK0
ENSG00000160469ENST00000585418Q8TDC3
ENSG00000160469ENST00000590333Q8TDC3
ENSG00000160469ENST00000591774K7EM68
ENSG00000160469ENST00000592539K7EN26

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194486212009Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.142
194486192009Loci at chromosomes 13, 19 and 20 influence age at natural menopause.59
188543182009C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.29
196489102009SADB phosphorylation of gamma-tubulin regulates centrosome duplication.29
221313682012Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.29
151502652004Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.21
183396222008Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.14
276771862016Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.5
250364022014Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.3

Citation

Dessen P

BRSK1 (BR serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43173/brsk1