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BRSK1 (BR serine/threonine kinase 1)

Identity

Alias_symbol (synonym)KIAA1811
Other aliashSAD1
HGNC (Hugo) BRSK1
LocusID (NCBI) 84446
Atlas_Id 43173
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55284166 and ends at 55312535 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRSK1 (19q13.42) / UCK1 (9q34.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRSK1   18994
Cards
Entrez_Gene (NCBI)BRSK1  84446  BR serine/threonine kinase 1
AliaseshSAD1
GeneCards (Weizmann)BRSK1
Ensembl hg19 (Hinxton)ENSG00000160469 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160469 [Gene_View]  chr19:55284166-55312535 [Contig_View]  BRSK1 [Vega]
ICGC DataPortalENSG00000160469
TCGA cBioPortalBRSK1
AceView (NCBI)BRSK1
Genatlas (Paris)BRSK1
WikiGenes84446
SOURCE (Princeton)BRSK1
Genetics Home Reference (NIH)BRSK1
Genomic and cartography
GoldenPath hg38 (UCSC)BRSK1  -     chr19:55284166-55312535 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRSK1  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblBRSK1 - 19q13.42 [CytoView hg19]  BRSK1 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIBRSK1 [Mapview hg19]  BRSK1 [Mapview hg38]
OMIM609235   
Gene and transcription
Genbank (Entrez)AB058714 AF479826 AF479827 AK124999 AL831945
RefSeq transcript (Entrez)NM_032430
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRSK1
Cluster EST : UnigeneHs.182081 [ NCBI ]
CGAP (NCI)Hs.182081
Alternative Splicing GalleryENSG00000160469
Gene ExpressionBRSK1 [ NCBI-GEO ]   BRSK1 [ EBI - ARRAY_EXPRESS ]   BRSK1 [ SEEK ]   BRSK1 [ MEM ]
Gene Expression Viewer (FireBrowse)BRSK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84446
GTEX Portal (Tissue expression)BRSK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDC3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDC3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDC3
Splice isoforms : SwissVarQ8TDC3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8TDC3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)BRSK1
DMDM Disease mutations84446
Blocks (Seattle)BRSK1
SuperfamilyQ8TDC3
Human Protein AtlasENSG00000160469
Peptide AtlasQ8TDC3
HPRD12533
IPIIPI00148020   IPI00185438   IPI01025701   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDC3
IntAct (EBI)Q8TDC3
FunCoupENSG00000160469
BioGRIDBRSK1
STRING (EMBL)BRSK1
ZODIACBRSK1
Ontologies - Pathways
QuickGOQ8TDC3
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  centrosome  protein phosphorylation  cellular response to DNA damage stimulus  neurotransmitter secretion  axonogenesis  synaptic vesicle  response to UV  response to ionizing radiation  protein kinase binding  establishment of cell polarity  cell junction  neuron differentiation  G2 DNA damage checkpoint  intracellular signal transduction  gamma-tubulin binding  tau-protein kinase activity  tau-protein kinase activity  centrosome duplication  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  centrosome  protein phosphorylation  cellular response to DNA damage stimulus  neurotransmitter secretion  axonogenesis  synaptic vesicle  response to UV  response to ionizing radiation  protein kinase binding  establishment of cell polarity  cell junction  neuron differentiation  G2 DNA damage checkpoint  intracellular signal transduction  gamma-tubulin binding  tau-protein kinase activity  tau-protein kinase activity  centrosome duplication  
NDEx NetworkBRSK1
Atlas of Cancer Signalling NetworkBRSK1
Wikipedia pathwaysBRSK1
Orthology - Evolution
OrthoDB84446
GeneTree (enSembl)ENSG00000160469
Phylogenetic Trees/Animal Genes : TreeFamBRSK1
HOVERGENQ8TDC3
HOGENOMQ8TDC3
Homologs : HomoloGeneBRSK1
Homology/Alignments : Family Browser (UCSC)BRSK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRSK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRSK1
dbVarBRSK1
ClinVarBRSK1
1000_GenomesBRSK1 
Exome Variant ServerBRSK1
ExAC (Exome Aggregation Consortium)BRSK1 (select the gene name)
Genetic variants : HAPMAP84446
Genomic Variants (DGV)BRSK1 [DGVbeta]
DECIPHERBRSK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRSK1 
Mutations
ICGC Data PortalBRSK1 
TCGA Data PortalBRSK1 
Broad Tumor PortalBRSK1
OASIS PortalBRSK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDBRSK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRSK1
DgiDB (Drug Gene Interaction Database)BRSK1
DoCM (Curated mutations)BRSK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRSK1 (select a term)
intoGenBRSK1
Cancer3DBRSK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609235   
Orphanet
MedgenBRSK1
Genetic Testing Registry BRSK1
NextProtQ8TDC3 [Medical]
TSGene84446
GENETestsBRSK1
Target ValidationBRSK1
Huge Navigator BRSK1 [HugePedia]
snp3D : Map Gene to Disease84446
BioCentury BCIQBRSK1
ClinGenBRSK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84446
Chemical/Pharm GKB GenePA134888976
Clinical trialBRSK1
Miscellaneous
canSAR (ICR)BRSK1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRSK1
EVEXBRSK1
GoPubMedBRSK1
iHOPBRSK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:25:50 CEST 2017

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