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BRWD1 (bromodomain and WD repeat domain containing 1)

Identity

Alias_namesC21orf107
WDR9
chromosome 21 open reading frame 107
WD repeat domain 9
Alias_symbol (synonym)FLJ11315
N143
DCAF19
Other alias
HGNC (Hugo) BRWD1
LocusID (NCBI) 54014
Atlas_Id 54159
Location 21q22.2  [Link to chromosome band 21q22]
Location_base_pair Starts at 39296437 and ends at 39313786 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRWD1 (21q22.2) / ABCA10 (17q24.3)BRWD1 (21q22.2) / ABCG1 (21q22.3)BRWD1 (21q22.2) / AHR (7p21.1)
BRWD1 (21q22.2) / APOL1 (22q12.3)BRWD1 (21q22.2) / CEP112 (17q24.1)BRWD1 (21q22.2) / CTDNEP1 (17p13.1)
BRWD1 (21q22.2) / DYRK1A (21q22.13)BRWD1 (21q22.2) / GSS (20q11.22)BRWD1 (21q22.2) / HLCS (21q22.13)
BRWD1 (21q22.2) / HUNK (21q22.11)BRWD1 (21q22.2) / LCA5L (21q22.2)BRWD1 (21q22.2) / SMC1A (Xp11.22)
BRWD1 (21q22.2) / WDR4 (21q22.3)CALD1 (7q33) / BRWD1 (21q22.2)DYRK1A (21q22.13) / BRWD1 (21q22.2)
GPM6A (4q34.2) / BRWD1 (21q22.2)MED13 (17q23.2) / BRWD1 (21q22.2)MTMR3 (22q12.2) / BRWD1 (21q22.2)
SLC25A28 (10q24.2) / BRWD1 (21q22.2)TRAPPC10 (21q22.3) / BRWD1 (21q22.2)TTC3 (21q22.13) / BRWD1 (21q22.2)
BRWD1 21q22.2 / ABCA10 17q24.3BRWD1 21q22.2 / ABCG1 21q22.3BRWD1 21q22.2 / DYRK1A 21q22.13
BRWD1 21q22.2 / HUNK 21q22.11BRWD1 21q22.2 / LCA5L 21q22.2BRWD1 21q22.2 / SMC1A Xp11.22
BRWD1 21q22.2 / WDR4 21q22.3DYRK1A 21q22.13 / BRWD1 21q22.2TRAPPC10 21q22.3 / BRWD1 21q22.2
TTC3 21q22.13 / BRWD1 21q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)BRWD1   12760
Cards
Entrez_Gene (NCBI)BRWD1  54014  bromodomain and WD repeat domain containing 1
AliasesC21orf107; DCAF19; N143; WDR9
GeneCards (Weizmann)BRWD1
Ensembl hg19 (Hinxton)ENSG00000185658 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185658 [Gene_View]  chr21:39296437-39313786 [Contig_View]  BRWD1 [Vega]
ICGC DataPortalENSG00000185658
TCGA cBioPortalBRWD1
AceView (NCBI)BRWD1
Genatlas (Paris)BRWD1
WikiGenes54014
SOURCE (Princeton)BRWD1
Genetics Home Reference (NIH)BRWD1
Genomic and cartography
GoldenPath hg38 (UCSC)BRWD1  -     chr21:39296437-39313786 -  21q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRWD1  -     21q22.2   [Description]    (hg19-Feb_2009)
EnsemblBRWD1 - 21q22.2 [CytoView hg19]  BRWD1 - 21q22.2 [CytoView hg38]
Mapping of homologs : NCBIBRWD1 [Mapview hg19]  BRWD1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001007246 NM_018963 NM_033656
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRWD1
Cluster EST : UnigeneHs.654740 [ NCBI ]
CGAP (NCI)Hs.654740
Alternative Splicing GalleryENSG00000185658
Gene ExpressionBRWD1 [ NCBI-GEO ]   BRWD1 [ EBI - ARRAY_EXPRESS ]   BRWD1 [ SEEK ]   BRWD1 [ MEM ]
Gene Expression Viewer (FireBrowse)BRWD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54014
GTEX Portal (Tissue expression)BRWD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSI6
Splice isoforms : SwissVarQ9NSI6
PhosPhoSitePlusQ9NSI6
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Bromodomain    Bromodomain_CS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00439    pfam00400   
Domain families : Smart (EMBL)BROMO (SM00297)  WD40 (SM00320)  
Conserved Domain (NCBI)BRWD1
DMDM Disease mutations54014
Blocks (Seattle)BRWD1
PDB (SRS)3Q2E   
PDB (PDBSum)3Q2E   
PDB (IMB)3Q2E   
PDB (RSDB)3Q2E   
Structural Biology KnowledgeBase3Q2E   
SCOP (Structural Classification of Proteins)3Q2E   
CATH (Classification of proteins structures)3Q2E   
SuperfamilyQ9NSI6
Human Protein AtlasENSG00000185658
Peptide AtlasQ9NSI6
HPRD11683
IPIIPI00289944   IPI00250716   IPI00746752   IPI00514526   IPI00894482   IPI00477599   IPI00654620   IPI00973289   IPI00894220   IPI00892735   IPI00892955   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSI6
IntAct (EBI)Q9NSI6
FunCoupENSG00000185658
BioGRIDBRWD1
STRING (EMBL)BRWD1
ZODIACBRWD1
Ontologies - Pathways
QuickGOQ9NSI6
Ontology : AmiGOmolecular_function  nucleus  nucleoplasm  nucleolus  cytosol  chromatin organization  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cytoskeleton organization  regulation of cell shape  
Ontology : EGO-EBImolecular_function  nucleus  nucleoplasm  nucleolus  cytosol  chromatin organization  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cytoskeleton organization  regulation of cell shape  
NDEx NetworkBRWD1
Atlas of Cancer Signalling NetworkBRWD1
Wikipedia pathwaysBRWD1
Orthology - Evolution
OrthoDB54014
GeneTree (enSembl)ENSG00000185658
Phylogenetic Trees/Animal Genes : TreeFamBRWD1
HOVERGENQ9NSI6
HOGENOMQ9NSI6
Homologs : HomoloGeneBRWD1
Homology/Alignments : Family Browser (UCSC)BRWD1
Gene fusions - Rearrangements
Fusion : MitelmanBRWD1/ABCA10 [21q22.2/17q24.3]  
Fusion : MitelmanBRWD1/ABCG1 [21q22.2/21q22.3]  [t(21;21)(q22;q22)]  
Fusion : MitelmanBRWD1/CEP112 [21q22.2/17q24.1]  [t(17;21)(q24;q22)]  
Fusion : MitelmanBRWD1/DYRK1A [21q22.2/21q22.13]  [t(21;21)(q22;q22)]  
Fusion : MitelmanBRWD1/HUNK [21q22.2/21q22.11]  [t(21;21)(q22;q22)]  
Fusion : MitelmanBRWD1/LCA5L [21q22.2/21q22.2]  [t(21;21)(q22;q22)]  
Fusion : MitelmanBRWD1/SMC1A [21q22.2/Xp11.22]  [t(X;21)(p11;q22)]  
Fusion : MitelmanBRWD1/WDR4 [21q22.2/21q22.3]  [t(21;21)(q22;q22)]  
Fusion : MitelmanDYRK1A/BRWD1 [21q22.13/21q22.2]  [t(21;21)(q22;q22)]  
Fusion : MitelmanTRAPPC10/BRWD1 [21q22.3/21q22.2]  [t(21;21)(q22;q22)]  
Fusion : MitelmanTTC3/BRWD1 [21q22.13/21q22.2]  [t(21;21)(q22;q22)]  
Fusion: TCGABRWD1 21q22.2 ABCA10 17q24.3 BRCA
Fusion: TCGABRWD1 21q22.2 ABCG1 21q22.3 BRCA
Fusion: TCGABRWD1 21q22.2 DYRK1A 21q22.13 BRCA
Fusion: TCGABRWD1 21q22.2 HUNK 21q22.11 LUAD
Fusion: TCGABRWD1 21q22.2 LCA5L 21q22.2 BRCA
Fusion: TCGABRWD1 21q22.2 SMC1A Xp11.22 LUAD
Fusion: TCGABRWD1 21q22.2 WDR4 21q22.3 BRCA
Fusion: TCGADYRK1A 21q22.13 BRWD1 21q22.2 BRCA
Fusion: TCGATRAPPC10 21q22.3 BRWD1 21q22.2 BRCA
Fusion: TCGATTC3 21q22.13 BRWD1 21q22.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRWD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRWD1
dbVarBRWD1
ClinVarBRWD1
1000_GenomesBRWD1 
Exome Variant ServerBRWD1
ExAC (Exome Aggregation Consortium)BRWD1 (select the gene name)
Genetic variants : HAPMAP54014
Genomic Variants (DGV)BRWD1 [DGVbeta]
DECIPHERBRWD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRWD1 
Mutations
ICGC Data PortalBRWD1 
TCGA Data PortalBRWD1 
Broad Tumor PortalBRWD1
OASIS PortalBRWD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRWD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRWD1
intOGen PortalBRWD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRWD1
DgiDB (Drug Gene Interaction Database)BRWD1
DoCM (Curated mutations)BRWD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRWD1 (select a term)
intoGenBRWD1
Cancer3DBRWD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenBRWD1
Genetic Testing Registry BRWD1
NextProtQ9NSI6 [Medical]
TSGene54014
GENETestsBRWD1
Target ValidationBRWD1
Huge Navigator BRWD1 [HugePedia]
snp3D : Map Gene to Disease54014
BioCentury BCIQBRWD1
ClinGenBRWD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54014
Chemical/Pharm GKB GenePA134906879
Clinical trialBRWD1
Miscellaneous
canSAR (ICR)BRWD1 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRWD1
EVEXBRWD1
GoPubMedBRWD1
iHOPBRWD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:59:35 CEST 2017

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