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BTG1 (BTG anti-proliferation factor 1)

Identity

Alias_namesB-cell translocation gene 1
Alias_symbol (synonym)APRO2
Other alias
HGNC (Hugo) BTG1
LocusID (NCBI) 694
Atlas_Id 110
Location 12q21.33  [Link to chromosome band 12q21]
Location_base_pair Starts at 92140278 and ends at 92145897 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BTG1 (12q21.33) / BTG1 (12q21.33)BTG1 (12q21.33) / MYC (8q24.21)JTB (1q21.3) / BTG1 (12q21.33)
MYC (8q24.21) / BTG1 (12q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;12)(q24;q22) BTG1/MYC


External links

Nomenclature
HGNC (Hugo)BTG1   1130
Cards
Entrez_Gene (NCBI)BTG1  694  BTG anti-proliferation factor 1
AliasesAPRO2
GeneCards (Weizmann)BTG1
Ensembl hg19 (Hinxton)ENSG00000133639 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133639 [Gene_View]  chr12:92140278-92145897 [Contig_View]  BTG1 [Vega]
ICGC DataPortalENSG00000133639
TCGA cBioPortalBTG1
AceView (NCBI)BTG1
Genatlas (Paris)BTG1
WikiGenes694
SOURCE (Princeton)BTG1
Genetics Home Reference (NIH)BTG1
Genomic and cartography
GoldenPath hg38 (UCSC)BTG1  -     chr12:92140278-92145897 -  12q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BTG1  -     12q21.33   [Description]    (hg19-Feb_2009)
EnsemblBTG1 - 12q21.33 [CytoView hg19]  BTG1 - 12q21.33 [CytoView hg38]
Mapping of homologs : NCBIBTG1 [Mapview hg19]  BTG1 [Mapview hg38]
OMIM109580   
Gene and transcription
Genbank (Entrez)AK307057 AK313309 BC009050 BC016759 BC064953
RefSeq transcript (Entrez)NM_001731
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BTG1
Cluster EST : UnigeneHs.255935 [ NCBI ]
CGAP (NCI)Hs.255935
Alternative Splicing GalleryENSG00000133639
Gene ExpressionBTG1 [ NCBI-GEO ]   BTG1 [ EBI - ARRAY_EXPRESS ]   BTG1 [ SEEK ]   BTG1 [ MEM ]
Gene Expression Viewer (FireBrowse)BTG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)694
GTEX Portal (Tissue expression)BTG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62324
Splice isoforms : SwissVarP62324
PhosPhoSitePlusP62324
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    BTG1   
Domain families : Pfam (Sanger)BTG (PF07742)   
Domain families : Pfam (NCBI)pfam07742   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)BTG1
DMDM Disease mutations694
Blocks (Seattle)BTG1
SuperfamilyP62324
Human Protein AtlasENSG00000133639
Peptide AtlasP62324
HPRD15912
IPIIPI00012364   IPI01021119   
Protein Interaction databases
DIP (DOE-UCLA)P62324
IntAct (EBI)P62324
FunCoupENSG00000133639
BioGRIDBTG1
STRING (EMBL)BTG1
ZODIACBTG1
Ontologies - Pathways
QuickGOP62324
Ontology : AmiGOtranscription cofactor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  regulation of transcription, DNA-templated  negative regulation of cell proliferation  cell migration  enzyme binding  kinase binding  negative regulation of cell growth  positive regulation of endothelial cell differentiation  positive regulation of myoblast differentiation  positive regulation of myoblast differentiation  positive regulation of angiogenesis  positive regulation of fibroblast apoptotic process  
Ontology : EGO-EBItranscription cofactor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  regulation of transcription, DNA-templated  negative regulation of cell proliferation  cell migration  enzyme binding  kinase binding  negative regulation of cell growth  positive regulation of endothelial cell differentiation  positive regulation of myoblast differentiation  positive regulation of myoblast differentiation  positive regulation of angiogenesis  positive regulation of fibroblast apoptotic process  
Pathways : BIOCARTABTG family proteins and cell cycle regulation [Genes]   
Pathways : KEGGRNA degradation   
NDEx NetworkBTG1
Atlas of Cancer Signalling NetworkBTG1
Wikipedia pathwaysBTG1
Orthology - Evolution
OrthoDB694
GeneTree (enSembl)ENSG00000133639
Phylogenetic Trees/Animal Genes : TreeFamBTG1
HOVERGENP62324
HOGENOMP62324
Homologs : HomoloGeneBTG1
Homology/Alignments : Family Browser (UCSC)BTG1
Gene fusions - Rearrangements
Fusion : MitelmanBTG1/MYC [12q21.33/8q24.21]  
Fusion Cancer (Beijing)JTB [1q21.3]  -  BTG1 [12q21.33]  [FUSC000359]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBTG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BTG1
dbVarBTG1
ClinVarBTG1
1000_GenomesBTG1 
Exome Variant ServerBTG1
ExAC (Exome Aggregation Consortium)BTG1 (select the gene name)
Genetic variants : HAPMAP694
Genomic Variants (DGV)BTG1 [DGVbeta]
DECIPHERBTG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBTG1 
Mutations
ICGC Data PortalBTG1 
TCGA Data PortalBTG1 
Broad Tumor PortalBTG1
OASIS PortalBTG1 [ Somatic mutations - Copy number]
Cancer Gene: CensusBTG1 
Somatic Mutations in Cancer : COSMICBTG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBTG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BTG1
DgiDB (Drug Gene Interaction Database)BTG1
DoCM (Curated mutations)BTG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BTG1 (select a term)
intoGenBTG1
Cancer3DBTG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109580   
Orphanet
MedgenBTG1
Genetic Testing Registry BTG1
NextProtP62324 [Medical]
TSGene694
GENETestsBTG1
Target ValidationBTG1
Huge Navigator BTG1 [HugePedia]
snp3D : Map Gene to Disease694
BioCentury BCIQBTG1
ClinGenBTG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD694
Chemical/Pharm GKB GenePA25450
Clinical trialBTG1
Miscellaneous
canSAR (ICR)BTG1 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBTG1
EVEXBTG1
GoPubMedBTG1
iHOPBTG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:56:19 CEST 2017

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