Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BTG2 (BTG anti-proliferation factor 2)

Identity

Alias_namesBTG family, member 2
BTG family member 2
Alias_symbol (synonym)PC3
TIS21
MGC126063
MGC126064
APRO1
Other alias
HGNC (Hugo) BTG2
LocusID (NCBI) 7832
Atlas_Id 848
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203305536 and ends at 203309601 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTG2 (1q32.1) / BTG2 (1q32.1)IL6ST (5q11.2) / BTG2 (1q32.1)SGSM2 (17p13.3) / BTG2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BTG2   1131
Cards
Entrez_Gene (NCBI)BTG2  7832  BTG anti-proliferation factor 2
AliasesAPRO1; PC3; TIS21
GeneCards (Weizmann)BTG2
Ensembl hg19 (Hinxton)ENSG00000159388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159388 [Gene_View]  chr1:203305536-203309601 [Contig_View]  BTG2 [Vega]
ICGC DataPortalENSG00000159388
TCGA cBioPortalBTG2
AceView (NCBI)BTG2
Genatlas (Paris)BTG2
WikiGenes7832
SOURCE (Princeton)BTG2
Genetics Home Reference (NIH)BTG2
Genomic and cartography
GoldenPath hg38 (UCSC)BTG2  -     chr1:203305536-203309601 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BTG2  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblBTG2 - 1q32.1 [CytoView hg19]  BTG2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIBTG2 [Mapview hg19]  BTG2 [Mapview hg38]
OMIM601597   
Gene and transcription
Genbank (Entrez)BC105948 BC105949 EU446924 U72649 Y09943
RefSeq transcript (Entrez)NM_006763
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BTG2
Cluster EST : UnigeneHs.519162 [ NCBI ]
CGAP (NCI)Hs.519162
Alternative Splicing GalleryENSG00000159388
Gene ExpressionBTG2 [ NCBI-GEO ]   BTG2 [ EBI - ARRAY_EXPRESS ]   BTG2 [ SEEK ]   BTG2 [ MEM ]
Gene Expression Viewer (FireBrowse)BTG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7832
GTEX Portal (Tissue expression)BTG2
Human Protein AtlasENSG00000159388-BTG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78543
Splice isoforms : SwissVarP78543
PhosPhoSitePlusP78543
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    BTG2   
Domain families : Pfam (Sanger)BTG (PF07742)   
Domain families : Pfam (NCBI)pfam07742   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)BTG2
DMDM Disease mutations7832
Blocks (Seattle)BTG2
PDB (SRS)3DJU    3E9V   
PDB (PDBSum)3DJU    3E9V   
PDB (IMB)3DJU    3E9V   
PDB (RSDB)3DJU    3E9V   
Structural Biology KnowledgeBase3DJU    3E9V   
SCOP (Structural Classification of Proteins)3DJU    3E9V   
CATH (Classification of proteins structures)3DJU    3E9V   
SuperfamilyP78543
Human Protein Atlas [tissue]ENSG00000159388-BTG2 [tissue]
Peptide AtlasP78543
HPRD03357
IPIIPI00020335   
Protein Interaction databases
DIP (DOE-UCLA)P78543
IntAct (EBI)P78543
FunCoupENSG00000159388
BioGRIDBTG2
STRING (EMBL)BTG2
ZODIACBTG2
Ontologies - Pathways
QuickGOP78543
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  cytosol  DNA repair  transcription, DNA-templated  protein methylation  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of cell proliferation  associative learning  response to mechanical stimulus  anterior/posterior pattern specification  response to organic cyclic compound  negative regulation of translation  dentate gyrus development  central nervous system neuron development  neuron projection development  skeletal muscle cell differentiation  response to peptide hormone  negative regulation of neuron apoptotic process  response to electrical stimulus  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  extracellular exosome  negative regulation of neural precursor cell proliferation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  cytosol  DNA repair  transcription, DNA-templated  protein methylation  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of cell proliferation  associative learning  response to mechanical stimulus  anterior/posterior pattern specification  response to organic cyclic compound  negative regulation of translation  dentate gyrus development  central nervous system neuron development  neuron projection development  skeletal muscle cell differentiation  response to peptide hormone  negative regulation of neuron apoptotic process  response to electrical stimulus  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  extracellular exosome  negative regulation of neural precursor cell proliferation  
Pathways : BIOCARTABTG family proteins and cell cycle regulation [Genes]   
Pathways : KEGGRNA degradation   
NDEx NetworkBTG2
Atlas of Cancer Signalling NetworkBTG2
Wikipedia pathwaysBTG2
Orthology - Evolution
OrthoDB7832
GeneTree (enSembl)ENSG00000159388
Phylogenetic Trees/Animal Genes : TreeFamBTG2
HOVERGENP78543
HOGENOMP78543
Homologs : HomoloGeneBTG2
Homology/Alignments : Family Browser (UCSC)BTG2
Gene fusions - Rearrangements
Tumor Fusion PortalBTG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBTG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BTG2
dbVarBTG2
ClinVarBTG2
1000_GenomesBTG2 
Exome Variant ServerBTG2
ExAC (Exome Aggregation Consortium)ENSG00000159388
GNOMAD BrowserENSG00000159388
Genetic variants : HAPMAP7832
Genomic Variants (DGV)BTG2 [DGVbeta]
DECIPHERBTG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBTG2 
Mutations
ICGC Data PortalBTG2 
TCGA Data PortalBTG2 
Broad Tumor PortalBTG2
OASIS PortalBTG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBTG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBTG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BTG2
DgiDB (Drug Gene Interaction Database)BTG2
DoCM (Curated mutations)BTG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BTG2 (select a term)
intoGenBTG2
Cancer3DBTG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601597   
Orphanet
DisGeNETBTG2
MedgenBTG2
Genetic Testing Registry BTG2
NextProtP78543 [Medical]
TSGene7832
GENETestsBTG2
Target ValidationBTG2
Huge Navigator BTG2 [HugePedia]
snp3D : Map Gene to Disease7832
BioCentury BCIQBTG2
ClinGenBTG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7832
Chemical/Pharm GKB GenePA25451
Clinical trialBTG2
Miscellaneous
canSAR (ICR)BTG2 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBTG2
EVEXBTG2
GoPubMedBTG2
iHOPBTG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:05:12 CET 2017

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