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BTG2 (BTG anti-proliferation factor 2)

Identity

Alias (NCBI)APRO1
PC3
TIS21
HGNC (Hugo) BTG2
HGNC Alias symbPC3
TIS21
MGC126063
MGC126064
APRO1
HGNC Alias nameB-cell translocation gene 2
 pheochromacytoma cell-3
 NGF-inducible anti-proliferative protein PC3
 nerve growth factor-inducible anti-proliferative
HGNC Previous nameBTG family, member 2
 BTG family member 2
LocusID (NCBI) 7832
Atlas_Id 848
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203305519 and ends at 203309601 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTG2 (1q32.1) / BTG2 (1q32.1)IL6ST (5q11.2) / BTG2 (1q32.1)SGSM2 (17p13.3) / BTG2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)BTG2   1131
Cards
Entrez_Gene (NCBI)BTG2    BTG anti-proliferation factor 2
AliasesAPRO1; PC3; TIS21
GeneCards (Weizmann)BTG2
Ensembl hg19 (Hinxton)ENSG00000159388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159388 [Gene_View]  ENSG00000159388 [Sequence]  chr1:203305519-203309601 [Contig_View]  BTG2 [Vega]
ICGC DataPortalENSG00000159388
TCGA cBioPortalBTG2
AceView (NCBI)BTG2
Genatlas (Paris)BTG2
SOURCE (Princeton)BTG2
Genetics Home Reference (NIH)BTG2
Genomic and cartography
GoldenPath hg38 (UCSC)BTG2  -     chr1:203305519-203309601 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BTG2  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathBTG2 - 1q32.1 [CytoView hg19]  BTG2 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000159388
Genome Data Viewer NCBIBTG2 [Mapview hg19]  
OMIM601597   
Gene and transcription
Genbank (Entrez)BC105948 BC105949 U72649 Y09943
RefSeq transcript (Entrez)NM_006763
Consensus coding sequences : CCDS (NCBI)BTG2
Gene ExpressionBTG2 [ NCBI-GEO ]   BTG2 [ EBI - ARRAY_EXPRESS ]   BTG2 [ SEEK ]   BTG2 [ MEM ]
Gene Expression Viewer (FireBrowse)BTG2 [ Firebrowse - Broad ]
GenevisibleExpression of BTG2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7832
GTEX Portal (Tissue expression)BTG2
Human Protein AtlasENSG00000159388-BTG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78543
PhosPhoSitePlusP78543
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    BTG    BTG-like_sf    BTG2   
Domain families : Pfam (Sanger)BTG (PF07742)   
Domain families : Pfam (NCBI)pfam07742   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)BTG2
PDB (RSDB)3DJU    3E9V   
PDB Europe3DJU    3E9V   
PDB (PDBSum)3DJU    3E9V   
PDB (IMB)3DJU    3E9V   
Structural Biology KnowledgeBase3DJU    3E9V   
SCOP (Structural Classification of Proteins)3DJU    3E9V   
CATH (Classification of proteins structures)3DJU    3E9V   
SuperfamilyP78543
AlphaFold pdb e-kbP78543   
Human Protein Atlas [tissue]ENSG00000159388-BTG2 [tissue]
HPRD03357
Protein Interaction databases
DIP (DOE-UCLA)P78543
IntAct (EBI)P78543
BioGRIDBTG2
STRING (EMBL)BTG2
ZODIACBTG2
Ontologies - Pathways
QuickGOP78543
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  transcription corepressor activity  protein binding  nucleus  cytoplasm  cytosol  DNA repair  protein methylation  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of cell population proliferation  negative regulation of cell population proliferation  associative learning  response to mechanical stimulus  anterior/posterior pattern specification  response to organic cyclic compound  negative regulation of translation  dentate gyrus development  central nervous system neuron development  neuron projection development  skeletal muscle cell differentiation  response to peptide hormone  negative regulation of neuron apoptotic process  negative regulation of mitotic cell cycle  response to electrical stimulus  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  extracellular exosome  negative regulation of neural precursor cell proliferation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  transcription corepressor activity  protein binding  nucleus  cytoplasm  cytosol  DNA repair  protein methylation  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of cell population proliferation  negative regulation of cell population proliferation  associative learning  response to mechanical stimulus  anterior/posterior pattern specification  response to organic cyclic compound  negative regulation of translation  dentate gyrus development  central nervous system neuron development  neuron projection development  skeletal muscle cell differentiation  response to peptide hormone  negative regulation of neuron apoptotic process  negative regulation of mitotic cell cycle  response to electrical stimulus  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  extracellular exosome  negative regulation of neural precursor cell proliferation  
Pathways : BIOCARTABTG family proteins and cell cycle regulation [Genes]   
Pathways : KEGGRNA degradation   
NDEx NetworkBTG2
Atlas of Cancer Signalling NetworkBTG2
Wikipedia pathwaysBTG2
Orthology - Evolution
OrthoDB7832
GeneTree (enSembl)ENSG00000159388
Phylogenetic Trees/Animal Genes : TreeFamBTG2
Homologs : HomoloGeneBTG2
Homology/Alignments : Family Browser (UCSC)BTG2
Gene fusions - Rearrangements
Fusion : QuiverBTG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBTG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BTG2
dbVarBTG2
ClinVarBTG2
MonarchBTG2
1000_GenomesBTG2 
Exome Variant ServerBTG2
GNOMAD BrowserENSG00000159388
Varsome BrowserBTG2
ACMGBTG2 variants
VarityP78543
Genomic Variants (DGV)BTG2 [DGVbeta]
DECIPHERBTG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBTG2 
Mutations
ICGC Data PortalBTG2 
TCGA Data PortalBTG2 
Broad Tumor PortalBTG2
OASIS PortalBTG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBTG2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBTG2
Mutations and Diseases : HGMDBTG2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaBTG2
DgiDB (Drug Gene Interaction Database)BTG2
DoCM (Curated mutations)BTG2
CIViC (Clinical Interpretations of Variants in Cancer)BTG2
Cancer3DBTG2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601597   
Orphanet
DisGeNETBTG2
MedgenBTG2
Genetic Testing Registry BTG2
NextProtP78543 [Medical]
GENETestsBTG2
Target ValidationBTG2
Huge Navigator BTG2 [HugePedia]
ClinGenBTG2
Clinical trials, drugs, therapy
MyCancerGenomeBTG2
Protein Interactions : CTDBTG2
Pharm GKB GenePA25451
PharosP78543
Clinical trialBTG2
Miscellaneous
canSAR (ICR)BTG2
HarmonizomeBTG2
DataMed IndexBTG2
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBTG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:01:33 CEST 2021

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