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BTN2A2 (butyrophilin subfamily 2 member A2)

Identity

Alias_namesbutyrophilin
Alias_symbol (synonym)BTF2
BT2.2
BTN2.2
Other alias
HGNC (Hugo) BTN2A2
LocusID (NCBI) 10385
Atlas_Id 56137
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26383101 and ends at 26394872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTN2A2 (6p22.2) / MAP1LC3A (20q11.22)RAB31 (18p11.22) / BTN2A2 (6p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BTN2A2   1137
Cards
Entrez_Gene (NCBI)BTN2A2  10385  butyrophilin subfamily 2 member A2
AliasesBT2.2; BTF2; BTN2.2
GeneCards (Weizmann)BTN2A2
Ensembl hg19 (Hinxton)ENSG00000124508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124508 [Gene_View]  ENSG00000124508 [Sequence]  chr6:26383101-26394872 [Contig_View]  BTN2A2 [Vega]
ICGC DataPortalENSG00000124508
TCGA cBioPortalBTN2A2
AceView (NCBI)BTN2A2
Genatlas (Paris)BTN2A2
WikiGenes10385
SOURCE (Princeton)BTN2A2
Genetics Home Reference (NIH)BTN2A2
Genomic and cartography
GoldenPath hg38 (UCSC)BTN2A2  -     chr6:26383101-26394872 +  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BTN2A2  -     6p22.2   [Description]    (hg19-Feb_2009)
EnsemblBTN2A2 - 6p22.2 [CytoView hg19]  BTN2A2 - 6p22.2 [CytoView hg38]
Mapping of homologs : NCBIBTN2A2 [Mapview hg19]  BTN2A2 [Mapview hg38]
OMIM613591   
Gene and transcription
Genbank (Entrez)AK123902 AK289883 AK293526 AK298570 AK304744
RefSeq transcript (Entrez)NM_001197237 NM_001197238 NM_001197239 NM_001197240 NM_006995 NM_181531
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BTN2A2
Cluster EST : UnigeneHs.373938 [ NCBI ]
CGAP (NCI)Hs.373938
Alternative Splicing GalleryENSG00000124508
Gene ExpressionBTN2A2 [ NCBI-GEO ]   BTN2A2 [ EBI - ARRAY_EXPRESS ]   BTN2A2 [ SEEK ]   BTN2A2 [ MEM ]
Gene Expression Viewer (FireBrowse)BTN2A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10385
GTEX Portal (Tissue expression)BTN2A2
Human Protein AtlasENSG00000124508-BTN2A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WVV5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WVV5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WVV5
Splice isoforms : SwissVarQ8WVV5
PhosPhoSitePlusQ8WVV5
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin_SPRY    ConA-like_dom_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    PRY    SPRY/PRY_BTN1/2    SPRY_dom   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam13765    pfam00622    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  PRY (SM00589)  SPRY (SM00449)  
Conserved Domain (NCBI)BTN2A2
DMDM Disease mutations10385
Blocks (Seattle)BTN2A2
SuperfamilyQ8WVV5
Human Protein Atlas [tissue]ENSG00000124508-BTN2A2 [tissue]
Peptide AtlasQ8WVV5
HPRD12545
IPIIPI00013576   IPI00550454   IPI00909539   IPI00373880   IPI00910853   IPI00908589   IPI00945845   IPI00946136   IPI00946856   IPI00945643   IPI00945957   IPI00945823   IPI00946363   
Protein Interaction databases
DIP (DOE-UCLA)Q8WVV5
IntAct (EBI)Q8WVV5
FunCoupENSG00000124508
BioGRIDBTN2A2
STRING (EMBL)BTN2A2
ZODIACBTN2A2
Ontologies - Pathways
QuickGOQ8WVV5
Ontology : AmiGOsignaling receptor binding  protein binding  plasma membrane  external side of plasma membrane  negative regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  negative regulation of cellular metabolic process  positive regulation of regulatory T cell differentiation  negative regulation of activated T cell proliferation  negative regulation of cytokine secretion  regulation of immune response  T cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of protein kinase B signaling  negative regulation of ERK1 and ERK2 cascade  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIsignaling receptor binding  protein binding  plasma membrane  external side of plasma membrane  negative regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  negative regulation of cellular metabolic process  positive regulation of regulatory T cell differentiation  negative regulation of activated T cell proliferation  negative regulation of cytokine secretion  regulation of immune response  T cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of protein kinase B signaling  negative regulation of ERK1 and ERK2 cascade  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkBTN2A2
Atlas of Cancer Signalling NetworkBTN2A2
Wikipedia pathwaysBTN2A2
Orthology - Evolution
OrthoDB10385
GeneTree (enSembl)ENSG00000124508
Phylogenetic Trees/Animal Genes : TreeFamBTN2A2
HOVERGENQ8WVV5
HOGENOMQ8WVV5
Homologs : HomoloGeneBTN2A2
Homology/Alignments : Family Browser (UCSC)BTN2A2
Gene fusions - Rearrangements
Fusion : QuiverBTN2A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBTN2A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BTN2A2
dbVarBTN2A2
ClinVarBTN2A2
1000_GenomesBTN2A2 
Exome Variant ServerBTN2A2
ExAC (Exome Aggregation Consortium)ENSG00000124508
GNOMAD BrowserENSG00000124508
Varsome BrowserBTN2A2
Genetic variants : HAPMAP10385
Genomic Variants (DGV)BTN2A2 [DGVbeta]
DECIPHERBTN2A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBTN2A2 
Mutations
ICGC Data PortalBTN2A2 
TCGA Data PortalBTN2A2 
Broad Tumor PortalBTN2A2
OASIS PortalBTN2A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBTN2A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBTN2A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BTN2A2
DgiDB (Drug Gene Interaction Database)BTN2A2
DoCM (Curated mutations)BTN2A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BTN2A2 (select a term)
intoGenBTN2A2
Cancer3DBTN2A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613591   
Orphanet
DisGeNETBTN2A2
MedgenBTN2A2
Genetic Testing Registry BTN2A2
NextProtQ8WVV5 [Medical]
TSGene10385
GENETestsBTN2A2
Target ValidationBTN2A2
Huge Navigator BTN2A2 [HugePedia]
snp3D : Map Gene to Disease10385
BioCentury BCIQBTN2A2
ClinGenBTN2A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10385
Chemical/Pharm GKB GenePA25457
Clinical trialBTN2A2
Miscellaneous
canSAR (ICR)BTN2A2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBTN2A2
EVEXBTN2A2
GoPubMedBTN2A2
iHOPBTN2A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:54:40 CET 2018

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