BTN3A1 (butyrophilin subfamily 3 member A1)

2011-06-01  

Identity

HGNC
LOCATION
6p22.2
LOCUSID
ALIAS
BT3.1,BTF5,BTN3.1,CD277
FUSION GENES

Other Information

Locus ID:

NCBI: 11119
MIM: 613593
HGNC: 1138
Ensembl: ENSG00000026950

Variants:

dbSNP: 11119
ClinVar: 11119
TCGA: ENSG00000026950
COSMIC: BTN3A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000026950ENST00000289361O00481
ENSG00000026950ENST00000414912O00481
ENSG00000026950ENST00000425234O00481
ENSG00000026950ENST00000427334A6PVC0
ENSG00000026950ENST00000450085E7EPR2
ENSG00000026950ENST00000476549O00481
ENSG00000026950ENST00000506698E9PFB8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Butyrophilin (BTN) family interactionsREACTOMER-HSA-8851680

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195718092009Common variants on chromosome 6p22.1 are associated with schizophrenia.407
227674972012Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.163
238726782013Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.147
247037792014The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.141
228469962012The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.63
256370252015Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.46
248906572014Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6.37
250655322014Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes.37
211134072010CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.36
264759292015Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.34

Citation

Dessen P

BTN3A1 (butyrophilin subfamily 3 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52247/btn3a1