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BTN3A2 (butyrophilin subfamily 3 member A2)

Identity

Alias_namesbutyrophilin
Alias_symbol (synonym)BTN3.2
Other aliasBT3.2
BTF4
CD277
HGNC (Hugo) BTN3A2
LocusID (NCBI) 11118
Atlas_Id 53072
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26365159 and ends at 26378320 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTN3A2 (6p22.2) / ARHGAP26 (5q31.3)BTN3A2 (6p22.2) / BTN3A1 (6p22.2)BTN3A2 (6p22.2) / HIST1H2AC (6p22.2)
BTN3A2 (6p22.2) / PRSS23 (11q14.2)PHB2 (12p13.31) / BTN3A2 (6p22.2)BTN3A2 6p22.2 / HIST1H2AC 6p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  BTN3A2/HIST1H2AC (6p22)


External links

Nomenclature
HGNC (Hugo)BTN3A2   1139
Cards
Entrez_Gene (NCBI)BTN3A2  11118  butyrophilin subfamily 3 member A2
AliasesBT3.2; BTF4; BTN3.2; CD277
GeneCards (Weizmann)BTN3A2
Ensembl hg19 (Hinxton)ENSG00000186470 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186470 [Gene_View]  ENSG00000186470 [Sequence]  chr6:26365159-26378320 [Contig_View]  BTN3A2 [Vega]
ICGC DataPortalENSG00000186470
TCGA cBioPortalBTN3A2
AceView (NCBI)BTN3A2
Genatlas (Paris)BTN3A2
WikiGenes11118
SOURCE (Princeton)BTN3A2
Genetics Home Reference (NIH)BTN3A2
Genomic and cartography
GoldenPath hg38 (UCSC)BTN3A2  -     chr6:26365159-26378320 +  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BTN3A2  -     6p22.2   [Description]    (hg19-Feb_2009)
EnsemblBTN3A2 - 6p22.2 [CytoView hg19]  BTN3A2 - 6p22.2 [CytoView hg38]
Mapping of homologs : NCBIBTN3A2 [Mapview hg19]  BTN3A2 [Mapview hg38]
OMIM613594   
Gene and transcription
Genbank (Entrez)AF257505 AK097330 AK290880 AK299417 AK303600
RefSeq transcript (Entrez)NM_001197246 NM_001197247 NM_001197248 NM_001197249 NM_007047
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BTN3A2
Cluster EST : UnigeneHs.376046 [ NCBI ]
CGAP (NCI)Hs.376046
Alternative Splicing GalleryENSG00000186470
Gene ExpressionBTN3A2 [ NCBI-GEO ]   BTN3A2 [ EBI - ARRAY_EXPRESS ]   BTN3A2 [ SEEK ]   BTN3A2 [ MEM ]
Gene Expression Viewer (FireBrowse)BTN3A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11118
GTEX Portal (Tissue expression)BTN3A2
Human Protein AtlasENSG00000186470-BTN3A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78410   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78410  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78410
Splice isoforms : SwissVarP78410
PhosPhoSitePlusP78410
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)BTN3A2
DMDM Disease mutations11118
Blocks (Seattle)BTN3A2
PDB (SRS)4F8Q   
PDB (PDBSum)4F8Q   
PDB (IMB)4F8Q   
PDB (RSDB)4F8Q   
Structural Biology KnowledgeBase4F8Q   
SCOP (Structural Classification of Proteins)4F8Q   
CATH (Classification of proteins structures)4F8Q   
SuperfamilyP78410
Human Protein Atlas [tissue]ENSG00000186470-BTN3A2 [tissue]
Peptide AtlasP78410
HPRD12547
IPIIPI00099583   IPI01013649   IPI00384734   IPI00982004   IPI00982560   IPI01008714   IPI00980260   IPI00980945   
Protein Interaction databases
DIP (DOE-UCLA)P78410
IntAct (EBI)P78410
FunCoupENSG00000186470
BioGRIDBTN3A2
STRING (EMBL)BTN3A2
ZODIACBTN3A2
Ontologies - Pathways
QuickGOP78410
Ontology : AmiGOT cell mediated immunity  signaling receptor binding  plasma membrane  plasma membrane  external side of plasma membrane  membrane  integral component of membrane  regulation of immune response  T cell receptor signaling pathway  interferon-gamma secretion  
Ontology : EGO-EBIT cell mediated immunity  signaling receptor binding  plasma membrane  plasma membrane  external side of plasma membrane  membrane  integral component of membrane  regulation of immune response  T cell receptor signaling pathway  interferon-gamma secretion  
NDEx NetworkBTN3A2
Atlas of Cancer Signalling NetworkBTN3A2
Wikipedia pathwaysBTN3A2
Orthology - Evolution
OrthoDB11118
GeneTree (enSembl)ENSG00000186470
Phylogenetic Trees/Animal Genes : TreeFamBTN3A2
HOVERGENP78410
HOGENOMP78410
Homologs : HomoloGeneBTN3A2
Homology/Alignments : Family Browser (UCSC)BTN3A2
Gene fusions - Rearrangements
Fusion : MitelmanBTN3A2/HIST1H2AC [6p22.2/6p22.2]  
Fusion PortalBTN3A2 6p22.2 HIST1H2AC 6p22.2 BRCA
Fusion Cancer (Beijing)BTN3A2 [6p22.2]  -  BTN3A1 [6p22.2]  [FUSC000773]
Fusion : QuiverBTN3A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBTN3A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BTN3A2
dbVarBTN3A2
ClinVarBTN3A2
1000_GenomesBTN3A2 
Exome Variant ServerBTN3A2
ExAC (Exome Aggregation Consortium)ENSG00000186470
GNOMAD BrowserENSG00000186470
Varsome BrowserBTN3A2
Genetic variants : HAPMAP11118
Genomic Variants (DGV)BTN3A2 [DGVbeta]
DECIPHERBTN3A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBTN3A2 
Mutations
ICGC Data PortalBTN3A2 
TCGA Data PortalBTN3A2 
Broad Tumor PortalBTN3A2
OASIS PortalBTN3A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBTN3A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBTN3A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BTN3A2
DgiDB (Drug Gene Interaction Database)BTN3A2
DoCM (Curated mutations)BTN3A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BTN3A2 (select a term)
intoGenBTN3A2
Cancer3DBTN3A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613594   
Orphanet
DisGeNETBTN3A2
MedgenBTN3A2
Genetic Testing Registry BTN3A2
NextProtP78410 [Medical]
TSGene11118
GENETestsBTN3A2
Target ValidationBTN3A2
Huge Navigator BTN3A2 [HugePedia]
snp3D : Map Gene to Disease11118
BioCentury BCIQBTN3A2
ClinGenBTN3A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11118
Chemical/Pharm GKB GenePA25460
Clinical trialBTN3A2
Miscellaneous
canSAR (ICR)BTN3A2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBTN3A2
EVEXBTN3A2
GoPubMedBTN3A2
iHOPBTN3A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:54:40 CET 2018

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