Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. |
Amir RE, Haecker H, Karin M, Ciechanover A. |
Oncogene. 2004 Apr 1;23(14):2540-7. |
PMID 14676825 |
|
HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates. |
Besnard-Guerin C, Belaidouni N, Lassot I, Segeral E, Jobart A, Marchal C, Benarous R. |
J Biol Chem. 2004 Jan 2;279(1):788-95. Epub 2003 Oct 14. |
PMID 14561767 |
|
Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. |
Bhatia N, Herter JR, Slaga TJ, Fuchs SY, Spiegelman VS. |
Oncogene. 2002 Feb 28;21(10):1501-9. |
PMID 11896578 |
|
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |
Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF. |
Nature. 2003 Nov 6;426(6962):87-91. |
PMID 14603323 |
|
Identification of a family of human F-box proteins. |
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M. |
Curr Biol. 1999 Oct 21;9(20):1177-9. |
PMID 10531035 |
|
Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U. |
Davis M, Hatzubai A, Andersen JS, Ben-Shushan E, Fisher GZ, Yaron A, Bauskin A, Mercurio F, Mann M, Ben-Neriah Y. |
Genes Dev. 2002 Feb 15;16(4):439-51. |
PMID 11850407 |
|
A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. |
Dhawan P, Richmond A. |
J Biol Chem. 2002 Mar 8;277(10):7920-8. Epub 2001 Dec 28. |
PMID 11773061 |
|
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. |
Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. |
Mol Cell Biol. 2007 Jun;27(11):4006-17. Epub 2007 Mar 26.. |
PMID 17387146 |
|
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. |
Eide EJ, Woolf MF, Kang H, Woolf P, Hurst W, Camacho F, Vielhaber EL, Giovanni A, Virshup DM. |
Mol Cell Biol. 2005 Apr;25(7):2795-807. |
PMID 15767683 |
|
Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. |
Fong A, Sun SC. |
J Biol Chem. 2002 Jun 21;277(25):22111-4. Epub 2002 May 6. |
PMID 11994270 |
|
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. |
Frescas D, Pagano M. |
Nat Rev Cancer. 2008 Jun;8(6):438-49. |
PMID 18500245 |
|
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. |
Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z. |
Oncogene. 1999 Mar 25;18(12):2039-46. |
PMID 10321728 |
|
APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers. |
Gerstein AV, Almeida TA, Zhao G, Chess E, Shih IeM, Buhler K, Pienta K, Rubin MA, Vessella R, Papadopoulos N. |
Genes Chromosomes Cancer. 2002 May;34(1):9-16. |
PMID 11921277 |
|
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. |
Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M. |
Nature. 2008 Mar 20;452(7185):365-9. |
PMID 18354482 |
|
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. |
Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good RA, Nakayama K. |
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63. |
PMID 10097128 |
|
Dual degradation signals control Gli protein stability and tumor formation. |
Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE. |
Genes Dev. 2006 Feb 1;20(3):276-81. Epub 2006 Jan 18. |
PMID 16421275 |
|
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. |
Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J. |
Dev Cell. 2005 Dec;9(6):819-30. |
PMID 16326393 |
|
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. |
Jiang J, Struhl G. |
Nature. 1998 Jan 29;391(6666):493-6. |
PMID 9461217 |
|
Systematic analysis and nomenclature of mammalian F-box proteins. |
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW. |
Genes Dev. 2004 Nov 1;18(21):2573-80. |
PMID 15520277 |
|
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. |
Kanemori Y, Uto K, Sagata N. |
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6279-84. Epub 2005 Apr 21. |
PMID 15845771 |
|
Somatic mutations of the beta-TrCP gene in gastric cancer. |
Kim CJ, Song JH, Cho YG, Kim YS, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS. |
APMIS. 2007 Feb;115(2):127-33. |
PMID 17295679 |
|
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. |
Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A, Nakayama K, Nakayama K. |
EMBO J. 1999 May 4;18(9):2401-10. |
PMID 10228155 |
|
Elevated expression of Wnt antagonists is a common event in hepatoblastomas. |
Koch A, Waha A, Hartmann W, Hrychyk A, Schuller U, Waha A, Wharton KA Jr, Fuchs SY, von Schweinitz D, Pietsch T. |
Clin Cancer Res. 2005 Jun 15;11(12):4295-304. |
PMID 15958610 |
|
Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP. |
Kroll M, Margottin F, Kohl A, Renard P, Durand H, Concordet JP, Bachelerie F, Arenzana-Seisdedos F, Benarous R. |
J Biol Chem. 1999 Mar 19;274(12):7941-5. |
PMID 10075690 |
|
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. |
Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC. |
Mol Cell Biol. 2003 Jan;23(1):402-13. |
PMID 12482991 |
|
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. |
Lassot I, Segeral E, Berlioz-Torrent C, Durand H, Groussin L, Hai T, Benarous R, Margottin-Goguet F. |
Mol Cell Biol. 2001 Mar;21(6):2192-202. |
PMID 11238952 |
|
Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells. |
Liu J, Suresh Kumar KG, Yu D, Molton SA, McMahon M, Herlyn M, Thomas-Tikhonenko A, Fuchs SY. |
Oncogene. 2007 Mar 22;26(13):1954-8. Epub 2006 Sep 25. |
PMID 17001349 |
|
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. |
Mailand N, Bekker-Jensen S, Bartek J, Lukas J. |
Mol Cell. 2006 Aug 4;23(3):307-18. |
PMID 16885021 |
|
Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells. |
Muerkoster S, Arlt A, Sipos B, Witt M, Grossmann M, Kloppel G, Kalthoff H, Folsch UR, Schafer H. |
Cancer Res. 2005 Feb 15;65(4):1316-24. |
PMID 15735017 |
|
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. |
Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israel A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A. |
EMBO J. 2000 Jun 1;19(11):2580-91. |
PMID 10835356 |
|
Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. |
Ougolkov A, Zhang B, Yamashita K, Bilim V, Mai M, Fuchs SY, Minamoto T. |
J Natl Cancer Inst. 2004 Aug 4;96(15):1161-70. |
PMID 15292388 |
|
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. |
Pan Y, Bai CB, Joyner AL, Wang B. |
Mol Cell Biol. 2006 May;26(9):3365-77. |
PMID 16611981 |
|
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. |
Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M. |
Mol Cell. 2006 Aug 4;23(3):319-29. |
PMID 16885022 |
|
Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics. |
Reischl S, Vanselow K, Westermark PO, Thierfelder N, Maier B, Herzel H, Kramer A. |
J Biol Rhythms. 2007 Oct;22(5):375-86. |
PMID 17876059 |
|
Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. |
Shirane M, Hatakeyama S, Hattori K, Nakayama K, Nakayama K. |
J Biol Chem. 1999 Oct 1;274(40):28169-74. |
PMID 10497169 |
|
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. |
Shirogane T, Jin J, Ang XL, Harper JW. |
J Biol Chem. 2005 Jul 22;280(29):26863-72. Epub 2005 May 24. |
PMID 15917222 |
|
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. |
Smelkinson MG, Zhou Q, Kalderon D. |
Dev Cell. 2007 Oct;13(4):481-95. |
PMID 17925225 |
|
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. |
Spencer E, Jiang J, Chen ZJ. |
Genes Dev. 1999 Feb 1;13(3):284-94. |
PMID 9990853 |
|
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. |
Spiegelman VS, Tang W, Chan AM, Igarashi M, Aaronson SA, Sassoon DA, Katoh M, Slaga TJ, Fuchs SY. |
J Biol Chem. 2002 Sep 27;277(39):36624-30. Epub 2002 Jul 31. |
PMID 12151397 |
|
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. |
Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K. |
J Biol Chem. 2000 Jan 28;275(4):2877-84. |
PMID 10644755 |
|
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. |
Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, Pan ZQ. |
Mol Cell. 1999 Apr;3(4):527-33. |
PMID 10230406 |
|
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. |
Tempe D, Casas M, Karaz S, Blanchet-Tournier MF, Concordet JP. |
Mol Cell Biol. 2006 Jun;26(11):4316-26. |
PMID 16705181 |
|
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. |
Wang B, Li Y. |
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):33-8. Epub 2005 Dec 21. |
PMID 16371461 |
|
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. |
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H. |
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. Epub 2004 Mar 22. |
PMID 15070733 |
|
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. |
Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. |
Nature. 2008 Mar 20;452(7185):370-4. |
PMID 18354483 |
|
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. |
Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. |
Genes Dev. 1999b Feb 1;13(3):270-83. |
PMID 9990852 |
|
The genomic landscapes of human breast and colorectal cancers. |
Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. |
Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11. |
PMID 17932254 |
|
beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. |
Wu C, Ghosh S. |
J Biol Chem. 1999 Oct 15;274(42):29591-4. |
PMID 10514424 |
|
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. |
Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y. |
Nature. 1998 Dec 10;396(6711):590-4. |
PMID 9859996 |
|