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BUB3 (BUB3, mitotic checkpoint protein)

Identity

Alias_namesBUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog
budding uninhibited by benzimidazoles 3 homolog (yeast)
Alias_symbol (synonym)BUB3L
Other aliashBUB3
HGNC (Hugo) BUB3
LocusID (NCBI) 9184
Atlas_Id 855
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 123154244 and ends at 123165370 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPN9 (15q24.2) / BUB3 (10q26.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BUB3   1151
Cards
Entrez_Gene (NCBI)BUB3  9184  BUB3, mitotic checkpoint protein
AliasesBUB3L; hBUB3
GeneCards (Weizmann)BUB3
Ensembl hg19 (Hinxton)ENSG00000154473 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154473 [Gene_View]  chr10:123154244-123165370 [Contig_View]  BUB3 [Vega]
ICGC DataPortalENSG00000154473
TCGA cBioPortalBUB3
AceView (NCBI)BUB3
Genatlas (Paris)BUB3
WikiGenes9184
SOURCE (Princeton)BUB3
Genetics Home Reference (NIH)BUB3
Genomic and cartography
GoldenPath hg38 (UCSC)BUB3  -     chr10:123154244-123165370 +  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BUB3  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblBUB3 - 10q26.13 [CytoView hg19]  BUB3 - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBIBUB3 [Mapview hg19]  BUB3 [Mapview hg38]
OMIM603719   
Gene and transcription
Genbank (Entrez)AF047472 AF047473 AF053304 AF081496 AK226060
RefSeq transcript (Entrez)NM_001007793 NM_004725
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BUB3
Cluster EST : UnigeneHs.418533 [ NCBI ]
CGAP (NCI)Hs.418533
Alternative Splicing GalleryENSG00000154473
Gene ExpressionBUB3 [ NCBI-GEO ]   BUB3 [ EBI - ARRAY_EXPRESS ]   BUB3 [ SEEK ]   BUB3 [ MEM ]
Gene Expression Viewer (FireBrowse)BUB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9184
GTEX Portal (Tissue expression)BUB3
Human Protein AtlasENSG00000154473-BUB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43684
Splice isoforms : SwissVarO43684
PhosPhoSitePlusO43684
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)BUB3
DMDM Disease mutations9184
Blocks (Seattle)BUB3
SuperfamilyO43684
Human Protein Atlas [tissue]ENSG00000154473-BUB3 [tissue]
Peptide AtlasO43684
HPRD04761
IPIIPI00013468   IPI00514701   IPI01010654   IPI00644568   IPI00644108   
Protein Interaction databases
DIP (DOE-UCLA)O43684
IntAct (EBI)O43684
FunCoupENSG00000154473
BioGRIDBUB3
STRING (EMBL)BUB3
ZODIACBUB3
Ontologies - Pathways
QuickGOO43684
Ontology : AmiGOmitotic sister chromatid segregation  kinetochore  condensed chromosome kinetochore  protein binding  nucleoplasm  cytosol  sister chromatid cohesion  attachment of spindle microtubules to kinetochore  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of chromosome segregation  spindle assembly checkpoint  
Ontology : EGO-EBImitotic sister chromatid segregation  kinetochore  condensed chromosome kinetochore  protein binding  nucleoplasm  cytosol  sister chromatid cohesion  attachment of spindle microtubules to kinetochore  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of chromosome segregation  spindle assembly checkpoint  
Pathways : KEGGCell cycle    HTLV-I infection   
NDEx NetworkBUB3
Atlas of Cancer Signalling NetworkBUB3
Wikipedia pathwaysBUB3
Orthology - Evolution
OrthoDB9184
GeneTree (enSembl)ENSG00000154473
Phylogenetic Trees/Animal Genes : TreeFamBUB3
HOVERGENO43684
HOGENOMO43684
Homologs : HomoloGeneBUB3
Homology/Alignments : Family Browser (UCSC)BUB3
Gene fusions - Rearrangements
Fusion: Tumor Portal BUB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBUB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BUB3
dbVarBUB3
ClinVarBUB3
1000_GenomesBUB3 
Exome Variant ServerBUB3
ExAC (Exome Aggregation Consortium)ENSG00000154473
GNOMAD BrowserENSG00000154473
Genetic variants : HAPMAP9184
Genomic Variants (DGV)BUB3 [DGVbeta]
DECIPHERBUB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBUB3 
Mutations
ICGC Data PortalBUB3 
TCGA Data PortalBUB3 
Broad Tumor PortalBUB3
OASIS PortalBUB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBUB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBUB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BUB3
DgiDB (Drug Gene Interaction Database)BUB3
DoCM (Curated mutations)BUB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BUB3 (select a term)
intoGenBUB3
Cancer3DBUB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603719   
Orphanet1351   
MedgenBUB3
Genetic Testing Registry BUB3
NextProtO43684 [Medical]
TSGene9184
GENETestsBUB3
Target ValidationBUB3
Huge Navigator BUB3 [HugePedia]
snp3D : Map Gene to Disease9184
BioCentury BCIQBUB3
ClinGenBUB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9184
Chemical/Pharm GKB GenePA25467
Clinical trialBUB3
Miscellaneous
canSAR (ICR)BUB3 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBUB3
EVEXBUB3
GoPubMedBUB3
iHOPBUB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:42:23 CET 2017

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