Atlas of Genetics and Cytogenetics in Oncology and Haematology


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C21orf2 (chromosome 21 open reading frame 2)

Identity

Alias_symbol (synonym)YF5
A2
LRRC76
Other aliasYF5/A2
HGNC (Hugo) C21orf2
LocusID (NCBI) 755
Atlas_Id 55850
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 45748827 and ends at 45759285 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C21orf2 (21q22.3) / PDXK (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)C21orf2   1260
Cards
Entrez_Gene (NCBI)C21orf2  755  chromosome 21 open reading frame 2
AliasesLRRC76; YF5/A2
GeneCards (Weizmann)C21orf2
Ensembl hg19 (Hinxton)ENSG00000160226 [Gene_View]  chr21:45748827-45759285 [Contig_View]  C21orf2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160226 [Gene_View]  chr21:45748827-45759285 [Contig_View]  C21orf2 [Vega]
ICGC DataPortalENSG00000160226
TCGA cBioPortalC21orf2
AceView (NCBI)C21orf2
Genatlas (Paris)C21orf2
WikiGenes755
SOURCE (Princeton)C21orf2
Genetics Home Reference (NIH)C21orf2
Genomic and cartography
GoldenPath hg19 (UCSC)C21orf2  -     chr21:45748827-45759285 -  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)C21orf2  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblC21orf2 - 21q22.3 [CytoView hg19]  C21orf2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIC21orf2 [Mapview hg19]  C21orf2 [Mapview hg38]
OMIM603191   
Gene and transcription
Genbank (Entrez)AB209578 BC031300 BC072012 BM761336 HG511889
RefSeq transcript (Entrez)NM_001271440 NM_001271441 NM_001271442 NM_004928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)C21orf2
Cluster EST : UnigeneHs.517331 [ NCBI ]
CGAP (NCI)Hs.517331
Alternative Splicing GalleryENSG00000160226
Gene ExpressionC21orf2 [ NCBI-GEO ]   C21orf2 [ EBI - ARRAY_EXPRESS ]   C21orf2 [ SEEK ]   C21orf2 [ MEM ]
Gene Expression Viewer (FireBrowse)C21orf2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)755
GTEX Portal (Tissue expression)C21orf2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43822   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43822  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43822
Splice isoforms : SwissVarO43822
PhosPhoSitePlusO43822
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    U2A'_phosphoprotein32A_C   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)LRRcap (SM00446)  
Conserved Domain (NCBI)C21orf2
DMDM Disease mutations755
Blocks (Seattle)C21orf2
SuperfamilyO43822
Human Protein AtlasENSG00000160226
Peptide AtlasO43822
IPIIPI00014472   IPI00884002   IPI00884134   IPI00216586   IPI00414362   
Protein Interaction databases
DIP (DOE-UCLA)O43822
IntAct (EBI)O43822
FunCoupENSG00000160226
BioGRIDC21orf2
STRING (EMBL)C21orf2
ZODIACC21orf2
Ontologies - Pathways
QuickGOO43822
Ontology : AmiGOmolecular_function  protein binding  cytoplasm  mitochondrion  plasma membrane  cytoskeleton organization  smoothened signaling pathway  regulation of cell shape  photoreceptor connecting cilium  ciliary basal body  cilium morphogenesis  
Ontology : EGO-EBImolecular_function  protein binding  cytoplasm  mitochondrion  plasma membrane  cytoskeleton organization  smoothened signaling pathway  regulation of cell shape  photoreceptor connecting cilium  ciliary basal body  cilium morphogenesis  
NDEx NetworkC21orf2
Atlas of Cancer Signalling NetworkC21orf2
Wikipedia pathwaysC21orf2
Orthology - Evolution
OrthoDB755
GeneTree (enSembl)ENSG00000160226
Phylogenetic Trees/Animal Genes : TreeFamC21orf2
HOVERGENO43822
HOGENOMO43822
Homologs : HomoloGeneC21orf2
Homology/Alignments : Family Browser (UCSC)C21orf2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerC21orf2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)C21orf2
dbVarC21orf2
ClinVarC21orf2
1000_GenomesC21orf2 
Exome Variant ServerC21orf2
ExAC (Exome Aggregation Consortium)C21orf2 (select the gene name)
Genetic variants : HAPMAP755
Genomic Variants (DGV)C21orf2 [DGVbeta]
DECIPHER (Syndromes)21:45748827-45759285  ENSG00000160226
CONAN: Copy Number AnalysisC21orf2 
Mutations
ICGC Data PortalC21orf2 
TCGA Data PortalC21orf2 
Broad Tumor PortalC21orf2
OASIS PortalC21orf2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICC21orf2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDC21orf2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch C21orf2
DgiDB (Drug Gene Interaction Database)C21orf2
DoCM (Curated mutations)C21orf2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)C21orf2 (select a term)
intoGenC21orf2
Cancer3DC21orf2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603191   
Orphanet
MedgenC21orf2
Genetic Testing Registry C21orf2
NextProtO43822 [Medical]
TSGene755
GENETestsC21orf2
Huge Navigator C21orf2 [HugePedia]
snp3D : Map Gene to Disease755
BioCentury BCIQC21orf2
ClinGenC21orf2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD755
Chemical/Pharm GKB GenePA25816
Clinical trialC21orf2
Miscellaneous
canSAR (ICR)C21orf2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineC21orf2
EVEXC21orf2
GoPubMedC21orf2
iHOPC21orf2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:54:33 CEST 2017

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