Identity
HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
C4B1,C4B12,C4B2,C4B3,C4B5,C4BD,C4B_2,C4F,CH,CO4,CPAMD3
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 721
MIM: 120820
HGNC: 1324
Ensembl: ENSG00000224389
Variants:
dbSNP: 721
ClinVar: 721
TCGA: ENSG00000224389
COSMIC: C4B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000224389 | ENST00000425700 | F5GXS0 |
| ENSG00000224389 | ENST00000435363 | P0C0L5 |
| ENSG00000224389 | ENST00000647698 | A0A3B3ISA6 |
| ENSG00000224389 | ENST00000649658 | A0A3B3ISD7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35017157 | 2023 | Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma. | 4 |
| 37105991 | 2023 | Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. | 4 |
| 35017157 | 2023 | Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma. | 4 |
| 37105991 | 2023 | Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. | 4 |
| 34358307 | 2022 | The BS variant of C4 protects against age-related loss of white matter microstructural integrity. | 0 |
| 35898513 | 2022 | Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD. | 0 |
| 34358307 | 2022 | The BS variant of C4 protects against age-related loss of white matter microstructural integrity. | 0 |
| 35898513 | 2022 | Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD. | 0 |
| 33433412 | 2021 | Glomerular C4d deposition in proliferative glomerular diseases. | 1 |
| 34299197 | 2021 | Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects. | 8 |
| 34480088 | 2021 | Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. | 19 |
| 33433412 | 2021 | Glomerular C4d deposition in proliferative glomerular diseases. | 1 |
| 34299197 | 2021 | Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects. | 8 |
| 34480088 | 2021 | Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. | 19 |
| 32499649 | 2020 | Complement genes contribute sex-biased vulnerability in diverse disorders. | 97 |
Citation
Dessen P
C4B (complement C4B (Chido blood group))
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/50871/c4b
