C5AR1 (complement C5a receptor 1)

2013-11-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
C5A,C5AR,C5R1,CD88
FUSION GENES

Other Information

Locus ID:

NCBI: 728
MIM: 113995
HGNC: 1338
Ensembl: ENSG00000197405

Variants:

dbSNP: 728
ClinVar: 728
TCGA: ENSG00000197405
COSMIC: C5AR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197405ENST00000355085P21730
ENSG00000197405ENST00000594787M0QZK7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178048362007TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.333
236843092013The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors.103
249225782014Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis.97
200444842010The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.85
165116062006A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.78
194642292009Complement component 5a (C5a).47
204845952010Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells.47
187532572008Complement 5a receptor inhibition improves renal allograft survival.38
193082632009C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.33
234792272013Changes and regulation of the C5a receptor on neutrophils during septic shock in humans.33

Citation

Dessen P

C5AR1 (complement C5a receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53617/c5ar1