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C5AR1 (complement C5a receptor 1)

Identity

Alias_namesC5R1
complement component 5 receptor 1 (C5a ligand)
complement component 5a receptor 1
Alias_symbol (synonym)C5A
C5AR
CD88
Other alias
HGNC (Hugo) C5AR1
LocusID (NCBI) 728
Atlas_Id 53617
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47309847 and ends at 47322070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C5AR1 (19q13.32) / SSR1 (6p24.3)GLTSCR1 (19q13.33) / C5AR1 (19q13.32)RIMKLA (1p34.2) / C5AR1 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)C5AR1   1338
Cards
Entrez_Gene (NCBI)C5AR1  728  complement C5a receptor 1
AliasesC5A; C5AR; C5R1; CD88
GeneCards (Weizmann)C5AR1
Ensembl hg19 (Hinxton)ENSG00000197405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197405 [Gene_View]  chr19:47309847-47322070 [Contig_View]  C5AR1 [Vega]
ICGC DataPortalENSG00000197405
TCGA cBioPortalC5AR1
AceView (NCBI)C5AR1
Genatlas (Paris)C5AR1
WikiGenes728
SOURCE (Princeton)C5AR1
Genetics Home Reference (NIH)C5AR1
Genomic and cartography
GoldenPath hg38 (UCSC)C5AR1  -     chr19:47309847-47322070 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)C5AR1  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblC5AR1 - 19q13.32 [CytoView hg19]  C5AR1 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIC5AR1 [Mapview hg19]  C5AR1 [Mapview hg38]
OMIM113995   
Gene and transcription
Genbank (Entrez)BC008982 BE042476 BI916506 BM830753 BT007358
RefSeq transcript (Entrez)NM_001736
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)C5AR1
Cluster EST : UnigeneHs.2161 [ NCBI ]
CGAP (NCI)Hs.2161
Alternative Splicing GalleryENSG00000197405
Gene ExpressionC5AR1 [ NCBI-GEO ]   C5AR1 [ EBI - ARRAY_EXPRESS ]   C5AR1 [ SEEK ]   C5AR1 [ MEM ]
Gene Expression Viewer (FireBrowse)C5AR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)728
GTEX Portal (Tissue expression)C5AR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21730   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21730  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21730
Splice isoforms : SwissVarP21730
PhosPhoSitePlusP21730
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Anaphtx_C5AR1    Anaphtx_C5AR1/C5AR2    Anphylx_rcpt    Formyl_rcpt-rel    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)C5AR1
DMDM Disease mutations728
Blocks (Seattle)C5AR1
SuperfamilyP21730
Human Protein AtlasENSG00000197405
Peptide AtlasP21730
HPRD00224
IPIIPI00010308   
Protein Interaction databases
DIP (DOE-UCLA)P21730
IntAct (EBI)P21730
FunCoupENSG00000197405
BioGRIDC5AR1
STRING (EMBL)C5AR1
ZODIACC5AR1
Ontologies - Pathways
QuickGOP21730
Ontology : AmiGOactivation of MAPK activity  complement component C5a binding  complement component C5a receptor activity  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  apoptotic process  chemotaxis  inflammatory response  immune response  cellular defense response  signal transduction  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  sensory perception of chemical stimulus  cell surface  positive regulation of vascular endothelial growth factor production  positive regulation of macrophage chemotaxis  basolateral plasma membrane  cell proliferation in hindbrain  regulation of complement activation  neutrophil chemotaxis  secretory granule membrane  animal organ regeneration  response to peptidoglycan  response to lipopolysaccharide  complement component C5a signaling pathway  mRNA transcription from RNA polymerase II promoter  neutrophil degranulation  negative regulation of neuron apoptotic process  apical part of cell  positive regulation of angiogenesis  positive regulation of epithelial cell proliferation  defense response to Gram-positive bacterium  leukocyte migration  cell chemotaxis  positive regulation of ERK1 and ERK2 cascade  positive regulation of neutrophil chemotaxis  
Ontology : EGO-EBIactivation of MAPK activity  complement component C5a binding  complement component C5a receptor activity  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  apoptotic process  chemotaxis  inflammatory response  immune response  cellular defense response  signal transduction  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  sensory perception of chemical stimulus  cell surface  positive regulation of vascular endothelial growth factor production  positive regulation of macrophage chemotaxis  basolateral plasma membrane  cell proliferation in hindbrain  regulation of complement activation  neutrophil chemotaxis  secretory granule membrane  animal organ regeneration  response to peptidoglycan  response to lipopolysaccharide  complement component C5a signaling pathway  mRNA transcription from RNA polymerase II promoter  neutrophil degranulation  negative regulation of neuron apoptotic process  apical part of cell  positive regulation of angiogenesis  positive regulation of epithelial cell proliferation  defense response to Gram-positive bacterium  leukocyte migration  cell chemotaxis  positive regulation of ERK1 and ERK2 cascade  positive regulation of neutrophil chemotaxis  
Pathways : KEGGNeuroactive ligand-receptor interaction    Complement and coagulation cascades    Staphylococcus aureus infection   
NDEx NetworkC5AR1
Atlas of Cancer Signalling NetworkC5AR1
Wikipedia pathwaysC5AR1
Orthology - Evolution
OrthoDB728
GeneTree (enSembl)ENSG00000197405
Phylogenetic Trees/Animal Genes : TreeFamC5AR1
HOVERGENP21730
HOGENOMP21730
Homologs : HomoloGeneC5AR1
Homology/Alignments : Family Browser (UCSC)C5AR1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)RIMKLA [1p34.2]  -  C5AR1 [19q13.32]  [FUSC000020]  [FUSC000020]  [FUSC000020]  [FUSC000020]  [FUSC000020]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerC5AR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)C5AR1
dbVarC5AR1
ClinVarC5AR1
1000_GenomesC5AR1 
Exome Variant ServerC5AR1
ExAC (Exome Aggregation Consortium)C5AR1 (select the gene name)
Genetic variants : HAPMAP728
Genomic Variants (DGV)C5AR1 [DGVbeta]
DECIPHERC5AR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisC5AR1 
Mutations
ICGC Data PortalC5AR1 
TCGA Data PortalC5AR1 
Broad Tumor PortalC5AR1
OASIS PortalC5AR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICC5AR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDC5AR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch C5AR1
DgiDB (Drug Gene Interaction Database)C5AR1
DoCM (Curated mutations)C5AR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)C5AR1 (select a term)
intoGenC5AR1
Cancer3DC5AR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113995   
Orphanet
MedgenC5AR1
Genetic Testing Registry C5AR1
NextProtP21730 [Medical]
TSGene728
GENETestsC5AR1
Huge Navigator C5AR1 [HugePedia]
snp3D : Map Gene to Disease728
BioCentury BCIQC5AR1
ClinGenC5AR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD728
Chemical/Pharm GKB GenePA25920
Clinical trialC5AR1
Miscellaneous
canSAR (ICR)C5AR1 (select the gene name)
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineC5AR1
EVEXC5AR1
GoPubMedC5AR1
iHOPC5AR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:08:28 CEST 2017

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