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C5AR2 (complement component 5a receptor 2)

Identity

Alias_namesGPR77
G protein-coupled receptor 77
Alias_symbol (synonym)C5L2
Other aliasGPF77
HGNC (Hugo) C5AR2
LocusID (NCBI) 27202
Atlas_Id 53215
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47332147 and ends at 47342015 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)C5AR2   4527
Cards
Entrez_Gene (NCBI)C5AR2  27202  complement component 5a receptor 2
AliasesC5L2; GPF77; GPR77
GeneCards (Weizmann)C5AR2
Ensembl hg19 (Hinxton)ENSG00000134830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134830 [Gene_View]  chr19:47332147-47342015 [Contig_View]  C5AR2 [Vega]
ICGC DataPortalENSG00000134830
TCGA cBioPortalC5AR2
AceView (NCBI)C5AR2
Genatlas (Paris)C5AR2
WikiGenes27202
SOURCE (Princeton)C5AR2
Genetics Home Reference (NIH)C5AR2
Genomic and cartography
GoldenPath hg38 (UCSC)C5AR2  -     chr19:47332147-47342015 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)C5AR2  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblC5AR2 - 19q13.32 [CytoView hg19]  C5AR2 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIC5AR2 [Mapview hg19]  C5AR2 [Mapview hg38]
OMIM609949   
Gene and transcription
Genbank (Entrez)AB038237 AK313994 BC067477 BC067478 BC067479
RefSeq transcript (Entrez)NM_001271749 NM_001271750 NM_018485
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)C5AR2
Cluster EST : UnigeneHs.534412 [ NCBI ]
CGAP (NCI)Hs.534412
Alternative Splicing GalleryENSG00000134830
Gene ExpressionC5AR2 [ NCBI-GEO ]   C5AR2 [ EBI - ARRAY_EXPRESS ]   C5AR2 [ SEEK ]   C5AR2 [ MEM ]
Gene Expression Viewer (FireBrowse)C5AR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27202
GTEX Portal (Tissue expression)C5AR2
Human Protein AtlasENSG00000134830-C5AR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P296   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P296  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P296
Splice isoforms : SwissVarQ9P296
PhosPhoSitePlusQ9P296
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Anaphtx_C5AR1/C5AR2    Anaphtx_C5AR2    Formyl_rcpt-rel    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)C5AR2
DMDM Disease mutations27202
Blocks (Seattle)C5AR2
SuperfamilyQ9P296
Human Protein Atlas [tissue]ENSG00000134830-C5AR2 [tissue]
Peptide AtlasQ9P296
HPRD17072
IPIIPI00020543   
Protein Interaction databases
DIP (DOE-UCLA)Q9P296
IntAct (EBI)Q9P296
FunCoupENSG00000134830
BioGRIDC5AR2
STRING (EMBL)C5AR2
ZODIACC5AR2
Ontologies - Pathways
QuickGOQ9P296
Ontology : AmiGOcomplement component C5a receptor activity  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  basal plasma membrane  regulation of complement activation  negative regulation of tumor necrosis factor production  complement component C5a signaling pathway  apical part of cell  positive regulation of epithelial cell proliferation  positive regulation of ERK1 and ERK2 cascade  negative regulation of neutrophil chemotaxis  negative regulation of interleukin-6 secretion  regulation of interleukin-8 secretion  
Ontology : EGO-EBIcomplement component C5a receptor activity  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  basal plasma membrane  regulation of complement activation  negative regulation of tumor necrosis factor production  complement component C5a signaling pathway  apical part of cell  positive regulation of epithelial cell proliferation  positive regulation of ERK1 and ERK2 cascade  negative regulation of neutrophil chemotaxis  negative regulation of interleukin-6 secretion  regulation of interleukin-8 secretion  
NDEx NetworkC5AR2
Atlas of Cancer Signalling NetworkC5AR2
Wikipedia pathwaysC5AR2
Orthology - Evolution
OrthoDB27202
GeneTree (enSembl)ENSG00000134830
Phylogenetic Trees/Animal Genes : TreeFamC5AR2
HOVERGENQ9P296
HOGENOMQ9P296
Homologs : HomoloGeneC5AR2
Homology/Alignments : Family Browser (UCSC)C5AR2
Gene fusions - Rearrangements
Fusion: Tumor Portal C5AR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerC5AR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)C5AR2
dbVarC5AR2
ClinVarC5AR2
1000_GenomesC5AR2 
Exome Variant ServerC5AR2
ExAC (Exome Aggregation Consortium)ENSG00000134830
GNOMAD BrowserENSG00000134830
Genetic variants : HAPMAP27202
Genomic Variants (DGV)C5AR2 [DGVbeta]
DECIPHERC5AR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisC5AR2 
Mutations
ICGC Data PortalC5AR2 
TCGA Data PortalC5AR2 
Broad Tumor PortalC5AR2
OASIS PortalC5AR2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDC5AR2
BioMutasearch C5AR2
DgiDB (Drug Gene Interaction Database)C5AR2
DoCM (Curated mutations)C5AR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)C5AR2 (select a term)
intoGenC5AR2
Cancer3DC5AR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609949   
Orphanet
MedgenC5AR2
Genetic Testing Registry C5AR2
NextProtQ9P296 [Medical]
TSGene27202
GENETestsC5AR2
Target ValidationC5AR2
Huge Navigator C5AR2 [HugePedia]
snp3D : Map Gene to Disease27202
BioCentury BCIQC5AR2
ClinGenC5AR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27202
Chemical/Pharm GKB GenePA28920
Clinical trialC5AR2
Miscellaneous
canSAR (ICR)C5AR2 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineC5AR2
EVEXC5AR2
GoPubMedC5AR2
iHOPC5AR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:42:41 CET 2017

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