C5AR2 (complement C5a receptor 2)

2013-03-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
C5L2,GPF77,GPR77

Other Information

Locus ID:

NCBI: 27202
MIM: 609949
HGNC: 4527
Ensembl: ENSG00000134830

Variants:

dbSNP: 27202
ClinVar: 27202
TCGA: ENSG00000134830
COSMIC: C5AR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134830ENST00000595464Q9P296
ENSG00000134830ENST00000600626Q9P296

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365933142023C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.1
380671352023C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.0
365933142023C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.1
380671352023C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.0
364668562022Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.2
364668562022Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.2
326117252020C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.24
326117252020C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.24
302584402018IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.13
302584402018IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.13
280330612017C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.6
280520002017Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.5
285763242017New concepts on the therapeutic control of complement anaphylatoxin receptors.39
280330612017C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.6
280520002017Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.5

Citation

Dessen P

C5AR2 (complement C5a receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53215/c5ar2