CA12 (carbonic anhydrase 12)

2003-06-01  

Identity

HGNC
LOCATION
15q22.2
LOCUSID
ALIAS
CA-XII,CAXII,HsT18816,T18816
FUSION GENES

Other Information

Locus ID:

NCBI: 771
MIM: 603263
HGNC: 1371
Ensembl: ENSG00000074410

Variants:

dbSNP: 771
ClinVar: 771
TCGA: ENSG00000074410
COSMIC: CA12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074410ENST00000178638O43570
ENSG00000074410ENST00000344366O43570
ENSG00000074410ENST00000422263B3KUB4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448871celecoxibChemicalPathwayassociated22336956
PA451728topiramateChemicalClinicalAnnotationassociatedPD21278619
PA451978zonisamideChemicalClinicalAnnotationassociatedPD21278619

References

Pubmed IDYearTitleCitations
184511792008Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer.53
183363152008Cancer-associated carbonic anhydrases and their inhibition.39
192913132009Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development.23
128541292003Carbonic anhydrase isozymes IX and XII in gastric tumors.22
256868272015Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells.22
204342302010Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway.21
183222682008Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.20
203984232010The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.20
164161082006Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer.17
126768952003Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma.16

Citation

Dessen P

CA12 (carbonic anhydrase 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/896/ca12