Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CA12 (carbonic anhydrase 12)

Identity

Alias_namescarbonic anhydrase XII
Alias_symbol (synonym)HsT18816
Other aliasCA-XII
CAXII
T18816
HGNC (Hugo) CA12
LocusID (NCBI) 771
Atlas_Id 896
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 63323531 and ends at 63382110 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP1G1 (16q22.2) / CA12 (15q22.2)CA12 (15q22.2) / CA12 (15q22.2)CA12 (15q22.2) / NDUFA6 (22q13.2)
MTPN (7q33) / CA12 (15q22.2)RPL32 (3p25.2) / CA12 (15q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CA12   1371
Cards
Entrez_Gene (NCBI)CA12  771  carbonic anhydrase 12
AliasesCA-XII; CAXII; HsT18816; T18816
GeneCards (Weizmann)CA12
Ensembl hg19 (Hinxton)ENSG00000074410 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074410 [Gene_View]  chr15:63323531-63382110 [Contig_View]  CA12 [Vega]
ICGC DataPortalENSG00000074410
TCGA cBioPortalCA12
AceView (NCBI)CA12
Genatlas (Paris)CA12
WikiGenes771
SOURCE (Princeton)CA12
Genetics Home Reference (NIH)CA12
Genomic and cartography
GoldenPath hg38 (UCSC)CA12  -     chr15:63323531-63382110 -  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CA12  -     15q22.2   [Description]    (hg19-Feb_2009)
EnsemblCA12 - 15q22.2 [CytoView hg19]  CA12 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBICA12 [Mapview hg19]  CA12 [Mapview hg38]
OMIM143860   603263   
Gene and transcription
Genbank (Entrez)AF037335 AF051882 AK000158 AK096845 AK315769
RefSeq transcript (Entrez)NM_001218 NM_001293642 NM_206925
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CA12
Cluster EST : UnigeneHs.603780 [ NCBI ]
CGAP (NCI)Hs.603780
Alternative Splicing GalleryENSG00000074410
Gene ExpressionCA12 [ NCBI-GEO ]   CA12 [ EBI - ARRAY_EXPRESS ]   CA12 [ SEEK ]   CA12 [ MEM ]
Gene Expression Viewer (FireBrowse)CA12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)771
GTEX Portal (Tissue expression)CA12
Human Protein AtlasENSG00000074410-CA12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43570   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43570
Splice isoforms : SwissVarO43570
Catalytic activity : Enzyme4.2.1.1 [ Enzyme-Expasy ]   4.2.1.14.2.1.1 [ IntEnz-EBI ]   4.2.1.1 [ BRENDA ]   4.2.1.1 [ KEGG ]   
PhosPhoSitePlusO43570
Domaine pattern : Prosite (Expaxy)ALPHA_CA_1 (PS00162)    ALPHA_CA_2 (PS51144)   
Domains : Interpro (EBI)Carbonic_anhydrase_a    Carbonic_anhydrase_a-class    Carbonic_anhydrase_a-class_CS    Carbonic_anhydrase_CA12   
Domain families : Pfam (Sanger)Carb_anhydrase (PF00194)   
Domain families : Pfam (NCBI)pfam00194   
Domain families : Smart (EMBL)Carb_anhydrase (SM01057)  
Conserved Domain (NCBI)CA12
DMDM Disease mutations771
Blocks (Seattle)CA12
PDB (SRS)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
PDB (PDBSum)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
PDB (IMB)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
PDB (RSDB)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
Structural Biology KnowledgeBase1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
SCOP (Structural Classification of Proteins)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
CATH (Classification of proteins structures)1JCZ    1JD0    4HT2    4KP5    4KP8    4Q0L    4QJ0    4QJO    4QJW    4WW8   
SuperfamilyO43570
Human Protein Atlas [tissue]ENSG00000074410-CA12 [tissue]
Peptide AtlasO43570
HPRD04464
IPIIPI00012895   IPI00221392   IPI00903233   IPI00014957   
Protein Interaction databases
DIP (DOE-UCLA)O43570
IntAct (EBI)O43570
FunCoupENSG00000074410
BioGRIDCA12
STRING (EMBL)CA12
ZODIACCA12
Ontologies - Pathways
QuickGOO43570
Ontology : AmiGOcarbonate dehydratase activity  plasma membrane  one-carbon metabolic process  zinc ion binding  bicarbonate transport  integral component of membrane  chloride ion homeostasis  
Ontology : EGO-EBIcarbonate dehydratase activity  plasma membrane  one-carbon metabolic process  zinc ion binding  bicarbonate transport  integral component of membrane  chloride ion homeostasis  
Pathways : KEGGNitrogen metabolism   
NDEx NetworkCA12
Atlas of Cancer Signalling NetworkCA12
Wikipedia pathwaysCA12
Orthology - Evolution
OrthoDB771
GeneTree (enSembl)ENSG00000074410
Phylogenetic Trees/Animal Genes : TreeFamCA12
HOVERGENO43570
HOGENOMO43570
Homologs : HomoloGeneCA12
Homology/Alignments : Family Browser (UCSC)CA12
Gene fusions - Rearrangements
Tumor Fusion PortalCA12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCA12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CA12
dbVarCA12
ClinVarCA12
1000_GenomesCA12 
Exome Variant ServerCA12
ExAC (Exome Aggregation Consortium)ENSG00000074410
GNOMAD BrowserENSG00000074410
Genetic variants : HAPMAP771
Genomic Variants (DGV)CA12 [DGVbeta]
DECIPHERCA12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCA12 
Mutations
ICGC Data PortalCA12 
TCGA Data PortalCA12 
Broad Tumor PortalCA12
OASIS PortalCA12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCA12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCA12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CA12
DgiDB (Drug Gene Interaction Database)CA12
DoCM (Curated mutations)CA12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CA12 (select a term)
intoGenCA12
Cancer3DCA12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM143860    603263   
Orphanet
DisGeNETCA12
MedgenCA12
Genetic Testing Registry CA12
NextProtO43570 [Medical]
TSGene771
GENETestsCA12
Target ValidationCA12
Huge Navigator CA12 [HugePedia]
snp3D : Map Gene to Disease771
BioCentury BCIQCA12
ClinGenCA12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD771
Chemical/Pharm GKB GenePA25987
Clinical trialCA12
Miscellaneous
canSAR (ICR)CA12 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCA12
EVEXCA12
GoPubMedCA12
iHOPCA12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:05:39 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.