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CA2 (carbonic anhydrase 2)

Identity

Alias_namescarbonic anhydrase II
Alias_symbol (synonym)Car2
CA-II
CAII
Other aliasCAC
HEL-76
HEL-S-282
HGNC (Hugo) CA2
LocusID (NCBI) 760
Atlas_Id 46552
Location 8q21.2  [Link to chromosome band 8q21]
Location_base_pair Starts at 85463902 and ends at 85481492 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MSC (8q13.3) / CA2 (8q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CA2   1373
Cards
Entrez_Gene (NCBI)CA2  760  carbonic anhydrase 2
AliasesCA-II; CAC; CAII; Car2; 
HEL-76; HEL-S-282
GeneCards (Weizmann)CA2
Ensembl hg19 (Hinxton)ENSG00000104267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104267 [Gene_View]  chr8:85463902-85481492 [Contig_View]  CA2 [Vega]
ICGC DataPortalENSG00000104267
TCGA cBioPortalCA2
AceView (NCBI)CA2
Genatlas (Paris)CA2
WikiGenes760
SOURCE (Princeton)CA2
Genetics Home Reference (NIH)CA2
Genomic and cartography
GoldenPath hg38 (UCSC)CA2  -     chr8:85463902-85481492 +  8q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CA2  -     8q21.2   [Description]    (hg19-Feb_2009)
EnsemblCA2 - 8q21.2 [CytoView hg19]  CA2 - 8q21.2 [CytoView hg38]
Mapping of homologs : NCBICA2 [Mapview hg19]  CA2 [Mapview hg38]
OMIM259730   611492   
Gene and transcription
Genbank (Entrez)AF015039 AK123309 AK312978 BC011949 BC035424
RefSeq transcript (Entrez)NM_000067 NM_001293675
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CA2
Cluster EST : UnigeneHs.155097 [ NCBI ]
CGAP (NCI)Hs.155097
Alternative Splicing GalleryENSG00000104267
Gene ExpressionCA2 [ NCBI-GEO ]   CA2 [ EBI - ARRAY_EXPRESS ]   CA2 [ SEEK ]   CA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)760
GTEX Portal (Tissue expression)CA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00918   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00918  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00918
Splice isoforms : SwissVarP00918
Catalytic activity : Enzyme4.2.1.1 [ Enzyme-Expasy ]   4.2.1.14.2.1.1 [ IntEnz-EBI ]   4.2.1.1 [ BRENDA ]   4.2.1.1 [ KEGG ]   
PhosPhoSitePlusP00918
Domaine pattern : Prosite (Expaxy)ALPHA_CA_1 (PS00162)    ALPHA_CA_2 (PS51144)   
Domains : Interpro (EBI)Carbonic_anhydrase_a    Carbonic_anhydrase_a-class    Carbonic_anhydrase_a-class_CS   
Domain families : Pfam (Sanger)Carb_anhydrase (PF00194)   
Domain families : Pfam (NCBI)pfam00194   
Domain families : Smart (EMBL)Carb_anhydrase (SM01057)  
Conserved Domain (NCBI)CA2
DMDM Disease mutations760
Blocks (Seattle)CA2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP00918
Human Protein AtlasENSG00000104267
Peptide AtlasP00918
HPRD02023
IPIIPI00218414   IPI01014108   IPI00790885   
Protein Interaction databases
DIP (DOE-UCLA)P00918
IntAct (EBI)P00918
FunCoupENSG00000104267
BioGRIDCA2
STRING (EMBL)CA2
ZODIACCA2
Ontologies - Pathways
QuickGOP00918
Ontology : AmiGOkidney development  morphogenesis of an epithelium  arylesterase activity  carbonate dehydratase activity  carbonate dehydratase activity  protein binding  extracellular space  cytoplasm  cytosol  plasma membrane  microvillus  one-carbon metabolic process  zinc ion binding  response to pH  response to zinc ion  carbon dioxide transport  bicarbonate transport  basolateral plasma membrane  axon  positive regulation of synaptic transmission, GABAergic  positive regulation of cellular pH reduction  angiotensin-activated signaling pathway  odontogenesis of dentin-containing tooth  myelin sheath  response to estrogen  regulation of anion transport  apical part of cell  positive regulation of osteoclast differentiation  positive regulation of bone resorption  secretion  response to steroid hormone  regulation of intracellular pH  extracellular exosome  cellular response to fluid shear stress  positive regulation of dipeptide transmembrane transport  regulation of chloride transport  
Ontology : EGO-EBIkidney development  morphogenesis of an epithelium  arylesterase activity  carbonate dehydratase activity  carbonate dehydratase activity  protein binding  extracellular space  cytoplasm  cytosol  plasma membrane  microvillus  one-carbon metabolic process  zinc ion binding  response to pH  response to zinc ion  carbon dioxide transport  bicarbonate transport  basolateral plasma membrane  axon  positive regulation of synaptic transmission, GABAergic  positive regulation of cellular pH reduction  angiotensin-activated signaling pathway  odontogenesis of dentin-containing tooth  myelin sheath  response to estrogen  regulation of anion transport  apical part of cell  positive regulation of osteoclast differentiation  positive regulation of bone resorption  secretion  response to steroid hormone  regulation of intracellular pH  extracellular exosome  cellular response to fluid shear stress  positive regulation of dipeptide transmembrane transport  regulation of chloride transport  
Pathways : KEGGNitrogen metabolism    Proximal tubule bicarbonate reclamation    Collecting duct acid secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion   
NDEx NetworkCA2
Atlas of Cancer Signalling NetworkCA2
Wikipedia pathwaysCA2
Orthology - Evolution
OrthoDB760
GeneTree (enSembl)ENSG00000104267
Phylogenetic Trees/Animal Genes : TreeFamCA2
HOVERGENP00918
HOGENOMP00918
Homologs : HomoloGeneCA2
Homology/Alignments : Family Browser (UCSC)CA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CA2
dbVarCA2
ClinVarCA2
1000_GenomesCA2 
Exome Variant ServerCA2
ExAC (Exome Aggregation Consortium)CA2 (select the gene name)
Genetic variants : HAPMAP760
Genomic Variants (DGV)CA2 [DGVbeta]
DECIPHERCA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCA2 
Mutations
ICGC Data PortalCA2 
TCGA Data PortalCA2 
Broad Tumor PortalCA2
OASIS PortalCA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CA2
DgiDB (Drug Gene Interaction Database)CA2
DoCM (Curated mutations)CA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CA2 (select a term)
intoGenCA2
Cancer3DCA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM259730    611492   
Orphanet555   
MedgenCA2
Genetic Testing Registry CA2
NextProtP00918 [Medical]
TSGene760
GENETestsCA2
Target ValidationCA2
Huge Navigator CA2 [HugePedia]
snp3D : Map Gene to Disease760
BioCentury BCIQCA2
ClinGenCA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD760
Chemical/Pharm GKB GenePA25989
Clinical trialCA2
Miscellaneous
canSAR (ICR)CA2 (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCA2
EVEXCA2
GoPubMedCA2
iHOPCA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:56:36 CEST 2017

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