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CABLES1 (Cdk5 and Abl enzyme substrate 1)

Identity

Alias_symbol (synonym)HsT2563
FLJ35924
Other aliasCABL1
CABLES
IK3-1
HGNC (Hugo) CABLES1
LocusID (NCBI) 91768
Atlas_Id 900
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 23155825 and ends at 23260470 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CABLES1 (18q11.2) / CABLES1 (18q11.2)CABLES1 (18q11.2) / RBBP8 (18q11.2)CABLES1 (18q11.2) / STARD3NL (7p14.1)
IGFLR1 (19q13.12) / CABLES1 (18q11.2)LAMA3 (18q11.2) / CABLES1 (18q11.2)TTC39C (18q11.2) / CABLES1 (18q11.2)
CABLES1 18q11.2 / RBBP8 18q11.2LAMA3 18q11.2 / CABLES1 18q11.2TTC39C 18q11.2 / CABLES1 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]

Solid Tumors TT_t1818q11q11ID103016 TT_t1818q11q11ID103020 TT_t1818q11q11ID103032

External links

Nomenclature
HGNC (Hugo)CABLES1   25097
Cards
Entrez_Gene (NCBI)CABLES1  91768  Cdk5 and Abl enzyme substrate 1
AliasesCABL1; CABLES; HsT2563; IK3-1
GeneCards (Weizmann)CABLES1
Ensembl hg19 (Hinxton)ENSG00000134508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134508 [Gene_View]  ENSG00000134508 [Sequence]  chr18:23155825-23260470 [Contig_View]  CABLES1 [Vega]
ICGC DataPortalENSG00000134508
TCGA cBioPortalCABLES1
AceView (NCBI)CABLES1
Genatlas (Paris)CABLES1
WikiGenes91768
SOURCE (Princeton)CABLES1
Genetics Home Reference (NIH)CABLES1
Genomic and cartography
GoldenPath hg38 (UCSC)CABLES1  -     chr18:23155825-23260470 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CABLES1  -     18q11.2   [Description]    (hg19-Feb_2009)
GoldenPathCABLES1 - 18q11.2 [CytoView hg19]  CABLES1 - 18q11.2 [CytoView hg38]
ImmunoBaseENSG00000134508
Mapping of homologs : NCBICABLES1 [Mapview hg19]  CABLES1 [Mapview hg38]
OMIM609194   
Gene and transcription
Genbank (Entrez)AF348525 AK025627 AK093243 AK296407 AK304880
RefSeq transcript (Entrez)NM_001100619 NM_001256438 NM_138375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CABLES1
Cluster EST : UnigeneHs.11108 [ NCBI ]
CGAP (NCI)Hs.11108
Alternative Splicing GalleryENSG00000134508
Gene ExpressionCABLES1 [ NCBI-GEO ]   CABLES1 [ EBI - ARRAY_EXPRESS ]   CABLES1 [ SEEK ]   CABLES1 [ MEM ]
Gene Expression Viewer (FireBrowse)CABLES1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91768
GTEX Portal (Tissue expression)CABLES1
Human Protein AtlasENSG00000134508-CABLES1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDN4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDN4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDN4
Splice isoforms : SwissVarQ8TDN4
PhosPhoSitePlusQ8TDN4
Domains : Interpro (EBI)CABLES1/2    Cyclin-like    Cyclin-like_sf    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam00134   
Conserved Domain (NCBI)CABLES1
DMDM Disease mutations91768
Blocks (Seattle)CABLES1
SuperfamilyQ8TDN4
Human Protein Atlas [tissue]ENSG00000134508-CABLES1 [tissue]
Peptide AtlasQ8TDN4
HPRD16461
IPIIPI00291427   IPI00178886   IPI00549691   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDN4
IntAct (EBI)Q8TDN4
FunCoupENSG00000134508
BioGRIDCABLES1
STRING (EMBL)CABLES1
ZODIACCABLES1
Ontologies - Pathways
QuickGOQ8TDN4
Ontology : AmiGOprotein binding  nucleus  cytosol  cell cycle  cell division  regulation of cell cycle  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  cell cycle  cell division  regulation of cell cycle  
NDEx NetworkCABLES1
Atlas of Cancer Signalling NetworkCABLES1
Wikipedia pathwaysCABLES1
Orthology - Evolution
OrthoDB91768
GeneTree (enSembl)ENSG00000134508
Phylogenetic Trees/Animal Genes : TreeFamCABLES1
HOGENOMQ8TDN4
Homologs : HomoloGeneCABLES1
Homology/Alignments : Family Browser (UCSC)CABLES1
Gene fusions - Rearrangements
Fusion : MitelmanCABLES1/RBBP8 [18q11.2/18q11.2]  
Fusion : MitelmanLAMA3/CABLES1 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanTTC39C/CABLES1 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion PortalCABLES1 18q11.2 RBBP8 18q11.2 BRCA
Fusion PortalLAMA3 18q11.2 CABLES1 18q11.2 LUAD
Fusion PortalTTC39C 18q11.2 CABLES1 18q11.2 OV
Fusion : QuiverCABLES1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCABLES1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CABLES1
dbVarCABLES1
ClinVarCABLES1
1000_GenomesCABLES1 
Exome Variant ServerCABLES1
ExAC (Exome Aggregation Consortium)ENSG00000134508
GNOMAD BrowserENSG00000134508
Varsome BrowserCABLES1
Genetic variants : HAPMAP91768
Genomic Variants (DGV)CABLES1 [DGVbeta]
DECIPHERCABLES1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCABLES1 
Mutations
ICGC Data PortalCABLES1 
TCGA Data PortalCABLES1 
Broad Tumor PortalCABLES1
OASIS PortalCABLES1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCABLES1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCABLES1
Mutations and Diseases : HGMDCABLES1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CABLES1
DgiDB (Drug Gene Interaction Database)CABLES1
DoCM (Curated mutations)CABLES1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CABLES1 (select a term)
intoGenCABLES1
Cancer3DCABLES1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609194   
Orphanet
DisGeNETCABLES1
MedgenCABLES1
Genetic Testing Registry CABLES1
NextProtQ8TDN4 [Medical]
TSGene91768
GENETestsCABLES1
Target ValidationCABLES1
Huge Navigator CABLES1 [HugePedia]
snp3D : Map Gene to Disease91768
BioCentury BCIQCABLES1
ClinGenCABLES1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91768
Chemical/Pharm GKB GenePA134880184
Clinical trialCABLES1
Miscellaneous
canSAR (ICR)CABLES1 (select the gene name)
DataMed IndexCABLES1
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCABLES1
EVEXCABLES1
GoPubMedCABLES1
iHOPCABLES1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:01:22 CEST 2019
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