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CACUL1 (CDK2 associated cullin domain 1)

Identity

Alias_namesC10orf46
chromosome 10 open reading frame 46
CDK2-associated, cullin domain 1
Alias_symbol (synonym)FLJ40409
MGC33215
CAC1
Other alias
HGNC (Hugo) CACUL1
LocusID (NCBI) 143384
Atlas_Id 53216
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 118680982 and ends at 118755246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACUL1 (10q26.11) / EIF3A (10q26.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CACUL1   23727
Cards
Entrez_Gene (NCBI)CACUL1  143384  CDK2 associated cullin domain 1
AliasesC10orf46; CAC1
GeneCards (Weizmann)CACUL1
Ensembl hg19 (Hinxton)ENSG00000151893 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151893 [Gene_View]  chr10:118680982-118755246 [Contig_View]  CACUL1 [Vega]
ICGC DataPortalENSG00000151893
TCGA cBioPortalCACUL1
AceView (NCBI)CACUL1
Genatlas (Paris)CACUL1
WikiGenes143384
SOURCE (Princeton)CACUL1
Genetics Home Reference (NIH)CACUL1
Genomic and cartography
GoldenPath hg38 (UCSC)CACUL1  -     chr10:118680982-118755246 -  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CACUL1  -     10q26.11   [Description]    (hg19-Feb_2009)
EnsemblCACUL1 - 10q26.11 [CytoView hg19]  CACUL1 - 10q26.11 [CytoView hg38]
Mapping of homologs : NCBICACUL1 [Mapview hg19]  CACUL1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ544771 AK026985 AK057742 AK097728 AK131008
RefSeq transcript (Entrez)NM_153810
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CACUL1
Cluster EST : UnigeneHs.669999 [ NCBI ]
CGAP (NCI)Hs.669999
Alternative Splicing GalleryENSG00000151893
Gene ExpressionCACUL1 [ NCBI-GEO ]   CACUL1 [ EBI - ARRAY_EXPRESS ]   CACUL1 [ SEEK ]   CACUL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CACUL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143384
GTEX Portal (Tissue expression)CACUL1
Human Protein AtlasENSG00000151893-CACUL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Y37   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Y37  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Y37
Splice isoforms : SwissVarQ86Y37
PhosPhoSitePlusQ86Y37
Domains : Interpro (EBI)Cullin_N    Cullin_repeat-like_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)   
Domain families : Pfam (NCBI)pfam00888   
Conserved Domain (NCBI)CACUL1
DMDM Disease mutations143384
Blocks (Seattle)CACUL1
SuperfamilyQ86Y37
Human Protein Atlas [tissue]ENSG00000151893-CACUL1 [tissue]
Peptide AtlasQ86Y37
HPRD12576
IPIIPI00410319   IPI00604792   IPI00604719   IPI01013213   
Protein Interaction databases
DIP (DOE-UCLA)Q86Y37
IntAct (EBI)Q86Y37
FunCoupENSG00000151893
BioGRIDCACUL1
STRING (EMBL)CACUL1
ZODIACCACUL1
Ontologies - Pathways
QuickGOQ86Y37
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein binding  positive regulation of cell proliferation  protein kinase binding  cullin-RING ubiquitin ligase complex  ubiquitin protein ligase binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein kinase activity  ubiquitin protein ligase activity  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein binding  positive regulation of cell proliferation  protein kinase binding  cullin-RING ubiquitin ligase complex  ubiquitin protein ligase binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein kinase activity  ubiquitin protein ligase activity  
NDEx NetworkCACUL1
Atlas of Cancer Signalling NetworkCACUL1
Wikipedia pathwaysCACUL1
Orthology - Evolution
OrthoDB143384
GeneTree (enSembl)ENSG00000151893
Phylogenetic Trees/Animal Genes : TreeFamCACUL1
HOVERGENQ86Y37
HOGENOMQ86Y37
Homologs : HomoloGeneCACUL1
Homology/Alignments : Family Browser (UCSC)CACUL1
Gene fusions - Rearrangements
Fusion : MitelmanCACUL1/EIF3A [10q26.11/10q26.11]  
Tumor Fusion PortalCACUL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCACUL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CACUL1
dbVarCACUL1
ClinVarCACUL1
1000_GenomesCACUL1 
Exome Variant ServerCACUL1
ExAC (Exome Aggregation Consortium)ENSG00000151893
GNOMAD BrowserENSG00000151893
Genetic variants : HAPMAP143384
Genomic Variants (DGV)CACUL1 [DGVbeta]
DECIPHERCACUL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCACUL1 
Mutations
ICGC Data PortalCACUL1 
TCGA Data PortalCACUL1 
Broad Tumor PortalCACUL1
OASIS PortalCACUL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCACUL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCACUL1
BioMutasearch CACUL1
DgiDB (Drug Gene Interaction Database)CACUL1
DoCM (Curated mutations)CACUL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CACUL1 (select a term)
intoGenCACUL1
Cancer3DCACUL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETCACUL1
MedgenCACUL1
Genetic Testing Registry CACUL1
NextProtQ86Y37 [Medical]
TSGene143384
GENETestsCACUL1
Target ValidationCACUL1
Huge Navigator CACUL1 [HugePedia]
snp3D : Map Gene to Disease143384
BioCentury BCIQCACUL1
ClinGenCACUL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143384
Chemical/Pharm GKB GenePA134869023
Clinical trialCACUL1
Miscellaneous
canSAR (ICR)CACUL1 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCACUL1
EVEXCACUL1
GoPubMedCACUL1
iHOPCACUL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:05:45 CET 2017

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