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CADM1 (cell adhesion molecule 1)

Identity

Alias_namesTSLC1
IGSF4
tumor suppressor in lung cancer 1
immunoglobulin superfamily, member 4
Alias_symbol (synonym)NECL2
ST17
BL2
SYNCAM
IGSF4A
Necl-2
SYNCAM1
RA175
Other aliassTSLC-1
sgIGSF
synCAM1
HGNC (Hugo) CADM1
LocusID (NCBI) 23705
Atlas_Id 40936
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 115044345 and ends at 115375241 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CADM1 (11q23.3) / ARCN1 (11q23.3)CADM1 (11q23.3) / COL1A2 (7q21.3)CADM1 (11q23.3) / MYO18A (17q11.2)
CADM1 (11q23.3) / TIMM9 (14q23.1)TENM4 (11q14.1) / CADM1 (11q23.3)CADM1 11q23.3 / ARCN1 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CADM1   5951
Cards
Entrez_Gene (NCBI)CADM1  23705  cell adhesion molecule 1
AliasesBL2; IGSF4; IGSF4A; NECL2; 
Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1
GeneCards (Weizmann)CADM1
Ensembl hg19 (Hinxton)ENSG00000182985 [Gene_View]  chr11:115044345-115375241 [Contig_View]  CADM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182985 [Gene_View]  chr11:115044345-115375241 [Contig_View]  CADM1 [Vega]
ICGC DataPortalENSG00000182985
TCGA cBioPortalCADM1
AceView (NCBI)CADM1
Genatlas (Paris)CADM1
WikiGenes23705
SOURCE (Princeton)CADM1
Genetics Home Reference (NIH)CADM1
Genomic and cartography
GoldenPath hg19 (UCSC)CADM1  -     chr11:115044345-115375241 -  11q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CADM1  -     11q23.3   [Description]    (hg38-Dec_2013)
EnsemblCADM1 - 11q23.3 [CytoView hg19]  CADM1 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBICADM1 [Mapview hg19]  CADM1 [Mapview hg38]
OMIM605686   
Gene and transcription
Genbank (Entrez)AB094146 AF132811 AK075502 AK172730 AK315245
RefSeq transcript (Entrez)NM_001098517 NM_001301043 NM_001301044 NM_001301045 NM_014333
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CADM1
Cluster EST : UnigeneHs.370510 [ NCBI ]
CGAP (NCI)Hs.370510
Alternative Splicing GalleryENSG00000182985
Gene ExpressionCADM1 [ NCBI-GEO ]   CADM1 [ EBI - ARRAY_EXPRESS ]   CADM1 [ SEEK ]   CADM1 [ MEM ]
Gene Expression Viewer (FireBrowse)CADM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23705
GTEX Portal (Tissue expression)CADM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BY67   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BY67  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BY67
Splice isoforms : SwissVarQ9BY67
PhosPhoSitePlusQ9BY67
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set    Neurexin-like   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    I-set (PF07679)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07679    pfam07686   
Domain families : Smart (EMBL)4.1m (SM00294)  IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CADM1
DMDM Disease mutations23705
Blocks (Seattle)CADM1
PDB (SRS)3BIN    4H5S   
PDB (PDBSum)3BIN    4H5S   
PDB (IMB)3BIN    4H5S   
PDB (RSDB)3BIN    4H5S   
Structural Biology KnowledgeBase3BIN    4H5S   
SCOP (Structural Classification of Proteins)3BIN    4H5S   
CATH (Classification of proteins structures)3BIN    4H5S   
SuperfamilyQ9BY67
Human Protein AtlasENSG00000182985
Peptide AtlasQ9BY67
HPRD05746
IPIIPI00003813   IPI00166392   IPI01012391   IPI01011015   IPI01011813   IPI01012400   IPI01009218   IPI01009596   IPI01015212   IPI01010524   IPI01016069   
Protein Interaction databases
DIP (DOE-UCLA)Q9BY67
IntAct (EBI)Q9BY67
FunCoupENSG00000182985
BioGRIDCADM1
STRING (EMBL)CADM1
ZODIACCADM1
Ontologies - Pathways
QuickGOQ9BY67
Ontology : AmiGOT cell mediated cytotoxicity  receptor activity  receptor binding  receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  cell-cell adherens junction  apoptotic process  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  multicellular organism development  spermatogenesis  cell recognition  cell recognition  basolateral plasma membrane  cell differentiation  PDZ domain binding  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  protein homodimerization activity  protein homodimerization activity  synapse  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of cytokine secretion  activated T cell proliferation  cell adhesion molecule binding  detection of stimulus  detection of stimulus  extracellular exosome  
Ontology : EGO-EBIT cell mediated cytotoxicity  receptor activity  receptor binding  receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  cell-cell adherens junction  apoptotic process  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  multicellular organism development  spermatogenesis  cell recognition  cell recognition  basolateral plasma membrane  cell differentiation  PDZ domain binding  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  protein homodimerization activity  protein homodimerization activity  synapse  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of cytokine secretion  activated T cell proliferation  cell adhesion molecule binding  detection of stimulus  detection of stimulus  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCADM1
Atlas of Cancer Signalling NetworkCADM1
Wikipedia pathwaysCADM1
Orthology - Evolution
OrthoDB23705
GeneTree (enSembl)ENSG00000182985
Phylogenetic Trees/Animal Genes : TreeFamCADM1
HOVERGENQ9BY67
HOGENOMQ9BY67
Homologs : HomoloGeneCADM1
Homology/Alignments : Family Browser (UCSC)CADM1
Gene fusions - Rearrangements
Fusion : MitelmanCADM1/ARCN1 [11q23.3/11q23.3]  
Fusion: TCGACADM1 11q23.3 ARCN1 11q23.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCADM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CADM1
dbVarCADM1
ClinVarCADM1
1000_GenomesCADM1 
Exome Variant ServerCADM1
ExAC (Exome Aggregation Consortium)CADM1 (select the gene name)
Genetic variants : HAPMAP23705
Genomic Variants (DGV)CADM1 [DGVbeta]
DECIPHER (Syndromes)11:115044345-115375241  ENSG00000182985
CONAN: Copy Number AnalysisCADM1 
Mutations
ICGC Data PortalCADM1 
TCGA Data PortalCADM1 
Broad Tumor PortalCADM1
OASIS PortalCADM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCADM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCADM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CADM1
DgiDB (Drug Gene Interaction Database)CADM1
DoCM (Curated mutations)CADM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CADM1 (select a term)
intoGenCADM1
Cancer3DCADM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605686   
Orphanet
MedgenCADM1
Genetic Testing Registry CADM1
NextProtQ9BY67 [Medical]
TSGene23705
GENETestsCADM1
Huge Navigator CADM1 [HugePedia]
snp3D : Map Gene to Disease23705
BioCentury BCIQCADM1
ClinGenCADM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23705
Chemical/Pharm GKB GenePA29764
Clinical trialCADM1
Miscellaneous
canSAR (ICR)CADM1 (select the gene name)
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCADM1
EVEXCADM1
GoPubMedCADM1
iHOPCADM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:54:50 CEST 2017

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