CADM2 (cell adhesion molecule 2)

2011-10-01 Affiliation

Identity

HGNC

CADM2

LOCATION

3p12.1

LOCUSID

253559

ALIAS

IGSF4D,NECL3,Necl-3,SynCAM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 253559
MIM: 609938
HGNC: 29849
Ensembl: ENSG00000175161

Variants:

dbSNP: 253559
ClinVar: 253559
TCGA: ENSG00000175161
COSMIC: CADM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175161	ENST00000383699	Q8N3J6
ENSG00000175161	ENST00000383699	G3XHN4
ENSG00000175161	ENST00000405615	Q8N3J6
ENSG00000175161	ENST00000407528	Q8N3J6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-cell junction organization	REACTOME	R-HSA-421270
Adherens junctions interactions	REACTOME	R-HSA-418990

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443309	Alcoholism	Disease	ClinicalAnnotation	associated		PD	32451486
PA448073	ethanol	Chemical	ClinicalAnnotation	associated		PD	32451486

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
27023175	2016	Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.	40
25335893	2014	The SynCAM synaptic cell adhesion molecules are involved in sensory axon pathfinding by regulating axon-axon contacts.	15
19861958	2010	Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.	11
30718321	2019	Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes.	9
21062931	2010	Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.	0
21864505	2011	A novel splicing variant of CADM2 as a protective transcript of psoriasis.	0
23643812	2013	Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression.	0
24240726	2014	Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy.	0
25869804	2016	GWAS for executive function and processing speed suggests involvement of the CADM2 gene.	0

Citation

Dessen P

CADM2 (cell adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52479/cadm2