CADM3 (cell adhesion molecule 3)

2009-08-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
BIgR,IGSF4B,NECL1,Necl-1,TSLL1,synCAM3
FUSION GENES

Other Information

Locus ID:

NCBI: 57863
MIM: 609743
HGNC: 17601
Ensembl: ENSG00000162706

Variants:

dbSNP: 57863
ClinVar: 57863
TCGA: ENSG00000162706
COSMIC: CADM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162706ENST00000368124Q8N126
ENSG00000162706ENST00000368125Q8N126
ENSG00000162706ENST00000416746A0A0C4DG09

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
157412372005Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes.41
185029842008HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium.35
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
213252822011Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions.24
164673052006Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.21
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
190621772009Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site.10
195655702009The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells.10
241122382013Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.5

Citation

Dessen P

CADM3 (cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51045/cadm3