CALCA (calcitonin related polypeptide alpha)

2007-02-01 Affiliation

Identity

HGNC

CALCA

LOCATION

11p15.2

LOCUSID

796

ALIAS

CALC1,CGRP,CGRP-I,CGRP-alpha,CGRP1,CT,KC,PCT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 796
MIM: 114130
HGNC: 1437
Ensembl: ENSG00000110680

Variants:

dbSNP: 796
ClinVar: 796
TCGA: ENSG00000110680
COSMIC: CALCA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000110680	ENST00000331587	P01258
ENSG00000110680	ENST00000361010	P06881
ENSG00000110680	ENST00000396372	P01258
ENSG00000110680	ENST00000469608	P01258
ENSG00000110680	ENST00000486207	P06881

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Amyloid fiber formation	REACTOME	R-HSA-977225
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Calcitonin-like ligand receptors	REACTOME	R-HSA-419812
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164754825	botulinum toxin type a	Chemical	ClinicalAnnotation	associated		PD
PA165108779	Migraine NOS	Disease	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19797133	2009	Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study.	65
23975872	2013	Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine.	56
21078153	2010	Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study.	47
18603306	2008	Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.	45
17101796	2007	Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.	42
18941191	2008	Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity.	38
22074408	2011	Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.	38
16236878	2005	Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index.	37
21083886	2010	Procalcitonin reflects bacteremia and bacterial load in urosepsis syndrome: a prospective observational study.	36

Citation

Dessen P

CALCA (calcitonin related polypeptide alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43682/calca