| | AIMP1 (4q24) / CALM1 (14q32.11) | CACNA1B (9q34.3) / CALM1 (14q32.11) | CALM1 (14q32.11) / ABI2 (2q33.2) |
| |
CALM1 (14q32.11) / CALM1 (14q32.11) | CALM1 (14q32.11) / CANX (5q35.3) | CALM1 (14q32.11) / MGP (12p12.3) |
| |
CALM1 (14q32.11) / MINK1 (17p13.2) | CALM1 (14q32.11) / PSME3 (17q21.31) | CALM1 (14q32.11) / RALA (7p14.1) |
| |
CALM1 (14q32.11) / UNC5CL (6p21.1) | CERS2 (1q21.3) / CALM1 (14q32.11) | DCXR (17q25.3) / CALM1 (14q32.11) |
| |
FSCN1 (7p22.1) / CALM1 (14q32.11) | HN1 (17q25.1) / CALM1 (14q32.11) | IRF2BP2 (1q42.3) / CALM1 (14q32.11) |
| |
NRDE2 (14q32.11) / CALM1 (14q32.11) | STAU1 (20q13.13) / CALM1 (14q32.11) |
| Nomenclature |
|---|
| HGNC (Hugo) | CALM1 1442 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CALM1 801 calmodulin 1 |
| Aliases | CALML2; CAMI; CPVT4; DD132; |
| LQT14; PHKD; caM |
| GeneCards (Weizmann) | CALM1 |
| Ensembl hg19 (Hinxton) | ENSG00000198668 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000198668 [Gene_View] ENSG00000198668 [Sequence] chr14:90396983-90408275 [Contig_View] CALM1 [Vega] |
| ICGC DataPortal | ENSG00000198668 |
| TCGA cBioPortal | CALM1 |
| AceView (NCBI) | CALM1 |
| Genatlas (Paris) | CALM1 |
| WikiGenes | 801 |
| SOURCE (Princeton) | CALM1 |
| Genetics Home Reference (NIH) | CALM1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CALM1 - chr14:90396983-90408275 + 14q32.11 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CALM1 - 14q32.11 [Description] (hg19-Feb_2009) |
| Ensembl | CALM1 - 14q32.11 [CytoView hg19] CALM1 - 14q32.11 [CytoView hg38] |
| Mapping of homologs : NCBI | CALM1 [Mapview hg19] CALM1 [Mapview hg38] |
| OMIM | 114180 614916 616247 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AH005375 AI651063 AK289937 AU122722 AY189287 |
| RefSeq transcript (Entrez) | NM_001166106 NM_006888 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CALM1 |
| Cluster EST : Unigene | Hs.282410 [ NCBI ] |
| CGAP (NCI) | Hs.282410 |
| Alternative Splicing Gallery | ENSG00000198668 |
| Gene Expression | CALM1 [ NCBI-GEO ] CALM1 [ EBI - ARRAY_EXPRESS ]
CALM1 [ SEEK ] CALM1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CALM1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 801 |
| GTEX Portal (Tissue expression) | CALM1 |
| Human Protein Atlas | ENSG00000198668-CALM1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P62158 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P62158 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P62158 |
| Splice isoforms : SwissVar | P62158 |
| PhosPhoSitePlus | P62158 |
| Domaine pattern : Prosite (Expaxy) | EF_HAND_1 (PS00018) EF_HAND_2 (PS50222) |
| Domains : Interpro (EBI) | EF-hand-dom_pair EF_Hand_1_Ca_BS EF_hand_dom |
| Domain families : Pfam (Sanger) | EF-hand_7 (PF13499) |
| Domain families : Pfam (NCBI) | pfam13499 |
| Domain families : Smart (EMBL) | EFh (SM00054) |
| Conserved Domain (NCBI) | CALM1 |
| DMDM Disease mutations | 801 |
| Blocks (Seattle) | CALM1 |
| PDB (SRS) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| PDB (PDBSum) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| PDB (IMB) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| PDB (RSDB) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| Structural Biology KnowledgeBase | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| SCOP (Structural Classification of Proteins) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| CATH (Classification of proteins structures) | 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5K7L 5K8Q |
| Superfamily | P62158 |
| Human Protein Atlas [tissue] | ENSG00000198668-CALM1 [tissue] |
| Peptide Atlas | P62158 |
| HPRD | 00241 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P62158 |
| IntAct (EBI) | P62158 |
| FunCoup | ENSG00000198668 |
| BioGRID | CALM1 |
| STRING (EMBL) | CALM1 |
| ZODIAC | CALM1 |
| Ontologies - Pathways |
|---|
| QuickGO | P62158 |
| Ontology : AmiGO | MAPK cascade spindle pole regulation of heart rate platelet degranulation Ras guanyl-nucleotide exchange factor activity calcium ion binding detection of calcium ion protein binding extracellular region nucleus nucleoplasm cytoplasm cytoplasm centrosome cytosol spindle microtubule plasma membrane glycogen catabolic process protein methylation muscle contraction G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ligand-gated ion channel activity calcium channel inhibitor activity protein kinase binding protein domain specific binding substantia nigra development regulation of rhodopsin mediated signaling pathway sarcomere positive regulation of cyclic nucleotide metabolic process positive regulation of cAMP biosynthetic process titin binding positive regulation of protein autophosphorylation vesicle N-terminal myristoylation domain binding regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity calcium channel complex positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway protein complex protein serine/threonine kinase activator activity inositol phosphate metabolic process ion channel binding regulation of nitric-oxide synthase activity cofactor metabolic process positive regulation of cyclic-nucleotide phosphodiesterase activity response to calcium ion transmembrane transport regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity extracellular exosome positive regulation of protein serine/threonine kinase activity protein phosphatase activator activity disordered domain specific binding regulation of cell communication by electrical coupling involved in cardiac conduction catalytic complex |
| Ontology : EGO-EBI | MAPK cascade spindle pole regulation of heart rate platelet degranulation Ras guanyl-nucleotide exchange factor activity calcium ion binding detection of calcium ion protein binding extracellular region nucleus nucleoplasm cytoplasm cytoplasm centrosome cytosol spindle microtubule plasma membrane glycogen catabolic process protein methylation muscle contraction G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ligand-gated ion channel activity calcium channel inhibitor activity protein kinase binding protein domain specific binding substantia nigra development regulation of rhodopsin mediated signaling pathway sarcomere positive regulation of cyclic nucleotide metabolic process positive regulation of cAMP biosynthetic process titin binding positive regulation of protein autophosphorylation vesicle N-terminal myristoylation domain binding regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity calcium channel complex positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway protein complex protein serine/threonine kinase activator activity inositol phosphate metabolic process ion channel binding regulation of nitric-oxide synthase activity cofactor metabolic process positive regulation of cyclic-nucleotide phosphodiesterase activity response to calcium ion transmembrane transport regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity extracellular exosome positive regulation of protein serine/threonine kinase activity protein phosphatase activator activity disordered domain specific binding regulation of cell communication by electrical coupling involved in cardiac conduction catalytic complex |
| Pathways : BIOCARTA | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes] fMLP induced chemokine gene expression in HMC-1 cells [Genes] Signaling Pathway from G-Protein Families [Genes] NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes] Links between Pyk2 and Map Kinases [Genes] Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes] Corticosteroids and cardioprotection [Genes] Actions of Nitric Oxide in the Heart [Genes] Role of MEF2D in T-cell Apoptosis [Genes] Bioactive Peptide Induced Signaling Pathway [Genes] Nitric Oxide Signaling Pathway [Genes] Regulation of PGC-1a [Genes] Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes] T Cell Receptor Signaling Pathway [Genes] BCR Signaling Pathway [Genes] Effects of calcineurin in Keratinocyte Differentiation [Genes] Endocytotic role of NDK, Phosphins and Dynamin [Genes] Ca++/ Calmodulin-dependent Protein Kinase Activation [Genes] Fc Epsilon Receptor I Signaling in Mast Cells [Genes] Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes] |
| Pathways : KEGG | Olfactory transduction Calcium signaling pathway Long-term potentiation GnRH signaling pathway Insulin signaling pathway Phosphatidylinositol signaling system Huntington's disease |
| NDEx Network | CALM1 |
| Atlas of Cancer Signalling Network | CALM1 |
| Wikipedia pathways | CALM1 |
| Orthology - Evolution |
|---|
| OrthoDB | 801 |
| GeneTree (enSembl) | ENSG00000198668 |
| Phylogenetic Trees/Animal Genes : TreeFam | CALM1 |
| HOVERGEN | P62158 |
| HOGENOM | P62158 |
| Homologs : HomoloGene | CALM1 |
| Homology/Alignments : Family Browser (UCSC) | CALM1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | HN1/CALM1 [17q25.1/14q32.11] [t(14;17)(q32;q25)] |
| Fusion : Quiver | CALM1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CALM1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CALM1 |
| dbVar | CALM1 |
| ClinVar | CALM1 |
| 1000_Genomes | CALM1 |
| Exome Variant Server | CALM1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000198668 |
| GNOMAD Browser | ENSG00000198668 |
| Genetic variants : HAPMAP | 801 |
| Genomic Variants (DGV) | CALM1 [DGVbeta] |
| DECIPHER | CALM1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CALM1 |
| Mutations |
|---|
| ICGC Data Portal | CALM1 |
| TCGA Data Portal | CALM1 |
| Broad Tumor Portal | CALM1 |
| OASIS Portal | CALM1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CALM1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CALM1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CALM1 |
| DgiDB (Drug Gene Interaction Database) | CALM1 |
| DoCM (Curated mutations) | CALM1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CALM1 (select a term) |
| intoGen | CALM1 |
| Cancer3D | CALM1(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 114180 614916 616247 |
| Orphanet | 3525 14727 |
| DisGeNET | CALM1 |
| Medgen | CALM1 |
| Genetic Testing Registry | CALM1
|
| NextProt | P62158 [Medical] |
| TSGene | 801 |
| GENETests | CALM1 |
| Target Validation | CALM1 |
| Huge Navigator |
CALM1 [HugePedia] |
| snp3D : Map Gene to Disease | 801 |
| BioCentury BCIQ | CALM1 |
| ClinGen | CALM1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 801 |
| Chemical/Pharm GKB Gene | PA26035 |
| Clinical trial | CALM1 |
| Miscellaneous |
|---|
| canSAR (ICR) | CALM1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 437 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CALM1 |
| EVEX | CALM1 |
| GoPubMed | CALM1 |
| iHOP | CALM1 |
