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CALM2 (calmodulin 2 (phosphorylase kinase, delta))

Identity

Alias_namescalmodulin 2 (phosphorylase kinase
Alias_symbol (synonym)PHKD
CAMII
Other aliasLQT15
PHKD2
caM
HGNC (Hugo) CALM2
LocusID (NCBI) 805
Atlas_Id 54927
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 47387221 and ends at 47403762 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CALM2 (2p21) / BTAF1 (10q23.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CALM2   1445
Cards
Entrez_Gene (NCBI)CALM2  805  calmodulin 2 (phosphorylase kinase, delta)
AliasesCAMII; LQT15; PHKD; PHKD2; 
caM
GeneCards (Weizmann)CALM2
Ensembl hg19 (Hinxton)ENSG00000143933 [Gene_View]  chr2:47387221-47403762 [Contig_View]  CALM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143933 [Gene_View]  chr2:47387221-47403762 [Contig_View]  CALM2 [Vega]
ICGC DataPortalENSG00000143933
TCGA cBioPortalCALM2
AceView (NCBI)CALM2
Genatlas (Paris)CALM2
WikiGenes805
SOURCE (Princeton)CALM2
Genetics Home Reference (NIH)CALM2
Genomic and cartography
GoldenPath hg19 (UCSC)CALM2  -     chr2:47387221-47403762 -  2p21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CALM2  -     2p21   [Description]    (hg38-Dec_2013)
EnsemblCALM2 - 2p21 [CytoView hg19]  CALM2 - 2p21 [CytoView hg38]
Mapping of homologs : NCBICALM2 [Mapview hg19]  CALM2 [Mapview hg38]
OMIM114182   616249   
Gene and transcription
Genbank (Entrez)AI873701 AK055130 AK315694 BC003354 BC006464
RefSeq transcript (Entrez)NM_001305624 NM_001305625 NM_001305626 NM_001743
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_042065 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)CALM2
Cluster EST : UnigeneHs.468442 [ NCBI ]
CGAP (NCI)Hs.468442
Alternative Splicing GalleryENSG00000143933
Gene ExpressionCALM2 [ NCBI-GEO ]   CALM2 [ EBI - ARRAY_EXPRESS ]   CALM2 [ SEEK ]   CALM2 [ MEM ]
Gene Expression Viewer (FireBrowse)CALM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)805
GTEX Portal (Tissue expression)CALM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62158
Splice isoforms : SwissVarP62158
PhosPhoSitePlusP62158
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)CALM2
DMDM Disease mutations805
Blocks (Seattle)CALM2
PDB (SRS)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
PDB (PDBSum)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
PDB (IMB)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
PDB (RSDB)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
Structural Biology KnowledgeBase1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
SCOP (Structural Classification of Proteins)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
CATH (Classification of proteins structures)1AJI    1CDL    1CLL    1CTR    1IWQ    1J7O    1J7P    1K90    1K93    1L7Z    1LVC    1NKF    1PK0    1S26    1SK6    1SW8    1WRZ    1XFU    1XFV    1XFW    1XFX    1XFY    1XFZ    1Y6W    1YR5    1YRT    1YRU    1ZOT    1ZUZ    2BE6    2F3Y    2F3Z    2HF5    2I08    2JZI    2K0E    2K0F    2K0J    2K61    2KNE    2KUG    2KUH    2L53    2L7L    2LGF    2LL6    2LL7    2LQC    2LQP    2LV6    2M0J    2M0K    2M55    2MG5    2N6A    2R28    2V01    2V02    2VAY    2W73    2WEL    2X0G    2Y4V    3BYA    3DVE    3DVJ    3DVK    3DVM    3EWT    3EWV    3G43    3HR4    3J41    3O77    3O78    3OXQ    3SUI    3UCT    3UCW    3UCY    4BW7    4BW8    4BYF    4DCK    4DJC    4GOW    4JPZ    4JQ0    4L79    4LZX    4M1L    4OVN    4Q57    4Q5U    4UMO    4UPU    4V0C   
SuperfamilyP62158
Human Protein AtlasENSG00000143933
Peptide AtlasP62158
HPRD00242
IPIIPI00075248   IPI00794543   IPI00386621   IPI01025684   IPI00945782   IPI01025362   IPI00915959   IPI00984320   IPI00916600   
Protein Interaction databases
DIP (DOE-UCLA)P62158
IntAct (EBI)P62158
FunCoupENSG00000143933
BioGRIDCALM2
STRING (EMBL)CALM2
ZODIACCALM2
Ontologies - Pathways
QuickGOP62158
Ontology : AmiGOG2/M transition of mitotic cell cycle  MAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  voltage-gated potassium channel complex  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  ligand-gated ion channel activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  positive regulation of cyclic nucleotide metabolic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  phospholipase binding  positive regulation of DNA binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  MAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  voltage-gated potassium channel complex  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  ligand-gated ion channel activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  positive regulation of cyclic nucleotide metabolic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  phospholipase binding  positive regulation of DNA binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Regulation of PGC-1a [Genes]    T Cell Receptor Signaling Pathway [Genes]    BCR Signaling Pathway [Genes]    Corticosteroids and cardioprotection [Genes]    Signaling Pathway from G-Protein Families [Genes]    Links between Pyk2 and Map Kinases [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Ca++/ Calmodulin-dependent Protein Kinase Activation [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Nitric Oxide Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    Endocytotic role of NDK, Phosphins and Dynamin [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Actions of Nitric Oxide in the Heart [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    Phosphatidylinositol signaling system    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Circadian entrainment    Long-term potentiation    Neurotrophin signaling pathway    Dopaminergic synapse    Olfactory transduction    Phototransduction    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Salivary secretion    Gastric acid secretion    Alzheimer's disease    Amphetamine addiction    Alcoholism    Pertussis    Tuberculosis    Glioma   
NDEx NetworkCALM2
Atlas of Cancer Signalling NetworkCALM2
Wikipedia pathwaysCALM2
Orthology - Evolution
OrthoDB805
GeneTree (enSembl)ENSG00000143933
Phylogenetic Trees/Animal Genes : TreeFamCALM2
HOVERGENP62158
HOGENOMP62158
Homologs : HomoloGeneCALM2
Homology/Alignments : Family Browser (UCSC)CALM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCALM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CALM2
dbVarCALM2
ClinVarCALM2
1000_GenomesCALM2 
Exome Variant ServerCALM2
ExAC (Exome Aggregation Consortium)CALM2 (select the gene name)
Genetic variants : HAPMAP805
Genomic Variants (DGV)CALM2 [DGVbeta]
DECIPHER (Syndromes)2:47387221-47403762  ENSG00000143933
CONAN: Copy Number AnalysisCALM2 
Mutations
ICGC Data PortalCALM2 
TCGA Data PortalCALM2 
Broad Tumor PortalCALM2
OASIS PortalCALM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCALM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCALM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CALM2
DgiDB (Drug Gene Interaction Database)CALM2
DoCM (Curated mutations)CALM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CALM2 (select a term)
intoGenCALM2
Cancer3DCALM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114182    616249   
Orphanet3525    14727   
MedgenCALM2
Genetic Testing Registry CALM2
NextProtP62158 [Medical]
TSGene805
GENETestsCALM2
Huge Navigator CALM2 [HugePedia]
snp3D : Map Gene to Disease805
BioCentury BCIQCALM2
ClinGenCALM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD805
Chemical/Pharm GKB GenePA26038
Clinical trialCALM2
Miscellaneous
canSAR (ICR)CALM2 (select the gene name)
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCALM2
EVEXCALM2
GoPubMedCALM2
iHOPCALM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:54:52 CEST 2017

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