Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CALM2 (calmodulin 2)

Identity

Alias_namescalmodulin 2 (phosphorylase kinase
Alias_symbol (synonym)PHKD
CAMII
Other aliasLQT15
PHKD2
caM
HGNC (Hugo) CALM2
LocusID (NCBI) 805
Atlas_Id 54927
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 47160082 and ends at 47176623 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALM2 (2p21) / BTAF1 (10q23.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CALM2   1445
Cards
Entrez_Gene (NCBI)CALM2  805  calmodulin 2
AliasesCAMII; LQT15; PHKD; PHKD2; 
caM
GeneCards (Weizmann)CALM2
Ensembl hg19 (Hinxton)ENSG00000143933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143933 [Gene_View]  chr2:47160082-47176623 [Contig_View]  CALM2 [Vega]
ICGC DataPortalENSG00000143933
TCGA cBioPortalCALM2
AceView (NCBI)CALM2
Genatlas (Paris)CALM2
WikiGenes805
SOURCE (Princeton)CALM2
Genetics Home Reference (NIH)CALM2
Genomic and cartography
GoldenPath hg38 (UCSC)CALM2  -     chr2:47160082-47176623 -  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CALM2  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblCALM2 - 2p21 [CytoView hg19]  CALM2 - 2p21 [CytoView hg38]
Mapping of homologs : NCBICALM2 [Mapview hg19]  CALM2 [Mapview hg38]
OMIM114182   616249   
Gene and transcription
Genbank (Entrez)AI873701 AK055130 AK315694 BC003354 BC006464
RefSeq transcript (Entrez)NM_001305624 NM_001305625 NM_001305626 NM_001743
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CALM2
Cluster EST : UnigeneHs.468442 [ NCBI ]
CGAP (NCI)Hs.468442
Alternative Splicing GalleryENSG00000143933
Gene ExpressionCALM2 [ NCBI-GEO ]   CALM2 [ EBI - ARRAY_EXPRESS ]   CALM2 [ SEEK ]   CALM2 [ MEM ]
Gene Expression Viewer (FireBrowse)CALM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)805
GTEX Portal (Tissue expression)CALM2
Human Protein AtlasENSG00000143933-CALM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62158
Splice isoforms : SwissVarP62158
PhosPhoSitePlusP62158
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)CALM2
DMDM Disease mutations805
Blocks (Seattle)CALM2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP62158
Human Protein Atlas [tissue]ENSG00000143933-CALM2 [tissue]
Peptide AtlasP62158
HPRD00242
IPIIPI00075248   IPI00794543   IPI00386621   IPI01025684   IPI00945782   IPI01025362   IPI00915959   IPI00984320   IPI00916600   
Protein Interaction databases
DIP (DOE-UCLA)P62158
IntAct (EBI)P62158
FunCoupENSG00000143933
BioGRIDCALM2
STRING (EMBL)CALM2
ZODIACCALM2
Ontologies - Pathways
QuickGOP62158
Ontology : AmiGOMAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  protein methylation  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  postsynaptic density  ligand-gated ion channel activity  calcium channel inhibitor activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  synaptic vesicle membrane  positive regulation of cyclic nucleotide metabolic process  positive regulation of cAMP biosynthetic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  mitochondrial membrane  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  myelin sheath  protein complex  phospholipase binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  establishment of protein localization to mitochondrial membrane  disordered domain specific binding  regulation of synaptic vesicle endocytosis  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  catalytic complex  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIMAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  protein methylation  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  postsynaptic density  ligand-gated ion channel activity  calcium channel inhibitor activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  synaptic vesicle membrane  positive regulation of cyclic nucleotide metabolic process  positive regulation of cAMP biosynthetic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  mitochondrial membrane  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  myelin sheath  protein complex  phospholipase binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  establishment of protein localization to mitochondrial membrane  disordered domain specific binding  regulation of synaptic vesicle endocytosis  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  catalytic complex  regulation of synaptic vesicle exocytosis  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkCALM2
Atlas of Cancer Signalling NetworkCALM2
Wikipedia pathwaysCALM2
Orthology - Evolution
OrthoDB805
GeneTree (enSembl)ENSG00000143933
Phylogenetic Trees/Animal Genes : TreeFamCALM2
HOVERGENP62158
HOGENOMP62158
Homologs : HomoloGeneCALM2
Homology/Alignments : Family Browser (UCSC)CALM2
Gene fusions - Rearrangements
Fusion: Tumor Portal CALM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCALM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CALM2
dbVarCALM2
ClinVarCALM2
1000_GenomesCALM2 
Exome Variant ServerCALM2
ExAC (Exome Aggregation Consortium)ENSG00000143933
GNOMAD BrowserENSG00000143933
Genetic variants : HAPMAP805
Genomic Variants (DGV)CALM2 [DGVbeta]
DECIPHERCALM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCALM2 
Mutations
ICGC Data PortalCALM2 
TCGA Data PortalCALM2 
Broad Tumor PortalCALM2
OASIS PortalCALM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCALM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCALM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CALM2
DgiDB (Drug Gene Interaction Database)CALM2
DoCM (Curated mutations)CALM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CALM2 (select a term)
intoGenCALM2
Cancer3DCALM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114182    616249   
Orphanet3525    14727   
MedgenCALM2
Genetic Testing Registry CALM2
NextProtP62158 [Medical]
TSGene805
GENETestsCALM2
Target ValidationCALM2
Huge Navigator CALM2 [HugePedia]
snp3D : Map Gene to Disease805
BioCentury BCIQCALM2
ClinGenCALM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD805
Chemical/Pharm GKB GenePA26038
Clinical trialCALM2
Miscellaneous
canSAR (ICR)CALM2 (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCALM2
EVEXCALM2
GoPubMedCALM2
iHOPCALM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:42:55 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.