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CALM3 (calmodulin 3)

Identity

Alias_namescalmodulin 3 (phosphorylase kinase
Alias_symbol (synonym)PHKD
Other aliasCaM
CaMIII
HEL-S-72
PHKD3
HGNC (Hugo) CALM3
LocusID (NCBI) 808
Atlas_Id 53209
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46601074 and ends at 46610782 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CADM3 (1q23.2) / CALM3 (19q13.32)CALM3 (19q13.32) / ANKRD26 (10p12.1)CALM3 (19q13.32) / CALM3 (19q13.32)
CALM3 (19q13.32) / DDX5 (17q23.3)CALM3 (19q13.32) / MSN (Xq12)CALM3 (19q13.32) / SCN3A (2q24.3)
CALM3 (19q13.32) / TROVE2 (1q31.2)CELSR2 (1p13.3) / CALM3 (19q13.32)COL18A1 (21q22.3) / CALM3 (19q13.32)
NCAM1 (11q23.2) / CALM3 (19q13.32)PLPP3 (1p32.2) / CALM3 (19q13.32)SPINT1 (15q15.1) / CALM3 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CALM3   1449
LRG (Locus Reference Genomic)LRG_1082
Cards
Entrez_Gene (NCBI)CALM3  808  calmodulin 3
AliasesCaM; CaMIII; HEL-S-72; PHKD; 
PHKD3
GeneCards (Weizmann)CALM3
Ensembl hg19 (Hinxton)ENSG00000160014 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160014 [Gene_View]  chr19:46601074-46610782 [Contig_View]  CALM3 [Vega]
ICGC DataPortalENSG00000160014
TCGA cBioPortalCALM3
AceView (NCBI)CALM3
Genatlas (Paris)CALM3
WikiGenes808
SOURCE (Princeton)CALM3
Genetics Home Reference (NIH)CALM3
Genomic and cartography
GoldenPath hg38 (UCSC)CALM3  -     chr19:46601074-46610782 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CALM3  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblCALM3 - 19q13.32 [CytoView hg19]  CALM3 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBICALM3 [Mapview hg19]  CALM3 [Mapview hg38]
OMIM114183   
Gene and transcription
Genbank (Entrez)AK094964 AK295927 AK310762 AL050207 AW883334
RefSeq transcript (Entrez)NM_001329921 NM_001329922 NM_001329923 NM_001329924 NM_001329925 NM_001329926 NM_005184
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CALM3
Cluster EST : UnigeneHs.515487 [ NCBI ]
CGAP (NCI)Hs.515487
Alternative Splicing GalleryENSG00000160014
Gene ExpressionCALM3 [ NCBI-GEO ]   CALM3 [ EBI - ARRAY_EXPRESS ]   CALM3 [ SEEK ]   CALM3 [ MEM ]
Gene Expression Viewer (FireBrowse)CALM3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)808
GTEX Portal (Tissue expression)CALM3
Human Protein AtlasENSG00000160014-CALM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62158
Splice isoforms : SwissVarP62158
PhosPhoSitePlusP62158
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)CALM3
DMDM Disease mutations808
Blocks (Seattle)CALM3
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP62158
Human Protein Atlas [tissue]ENSG00000160014-CALM3 [tissue]
Peptide AtlasP62158
HPRD00243
Protein Interaction databases
DIP (DOE-UCLA)P62158
IntAct (EBI)P62158
FunCoupENSG00000160014
BioGRIDCALM3
STRING (EMBL)CALM3
ZODIACCALM3
Ontologies - Pathways
QuickGOP62158
Ontology : AmiGOMAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  protein methylation  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  postsynaptic density  ligand-gated ion channel activity  calcium channel inhibitor activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  synaptic vesicle membrane  positive regulation of cyclic nucleotide metabolic process  positive regulation of cAMP biosynthetic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  mitochondrial membrane  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  myelin sheath  protein complex  phospholipase binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  establishment of protein localization to mitochondrial membrane  disordered domain specific binding  regulation of synaptic vesicle endocytosis  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  catalytic complex  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIMAPK cascade  spindle pole  response to amphetamine  regulation of heart rate  platelet degranulation  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  detection of calcium ion  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  spindle microtubule  plasma membrane  glycogen catabolic process  protein methylation  muscle contraction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  Wnt signaling pathway, calcium modulating pathway  adenylate cyclase binding  inositol-1,4,5-trisphosphate 3-kinase activity  positive regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  postsynaptic density  ligand-gated ion channel activity  calcium channel inhibitor activity  protein kinase binding  protein domain specific binding  substantia nigra development  regulation of rhodopsin mediated signaling pathway  sarcomere  nitric-oxide synthase regulator activity  growth cone  synaptic vesicle membrane  positive regulation of cyclic nucleotide metabolic process  positive regulation of cAMP biosynthetic process  titin binding  type 3 metabotropic glutamate receptor binding  positive regulation of protein autophosphorylation  mitochondrial membrane  vesicle  thioesterase binding  N-terminal myristoylation domain binding  regulation of cytokinesis  positive regulation of phosphoprotein phosphatase activity  ion transmembrane transport  calcium channel complex  positive regulation of protein dephosphorylation  Fc-epsilon receptor signaling pathway  myelin sheath  protein complex  phospholipase binding  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  phosphatidylinositol 3-kinase binding  inositol phosphate metabolic process  ion channel binding  calcium-dependent protein binding  nitric-oxide synthase binding  regulation of nitric-oxide synthase activity  positive regulation of nitric-oxide synthase activity  positive regulation of cyclic-nucleotide phosphodiesterase activity  response to corticosterone  response to calcium ion  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  positive regulation of protein serine/threonine kinase activity  protein phosphatase activator activity  establishment of protein localization to mitochondrial membrane  disordered domain specific binding  regulation of synaptic vesicle endocytosis  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  catalytic complex  regulation of synaptic vesicle exocytosis  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkCALM3
Atlas of Cancer Signalling NetworkCALM3
Wikipedia pathwaysCALM3
Orthology - Evolution
OrthoDB808
GeneTree (enSembl)ENSG00000160014
Phylogenetic Trees/Animal Genes : TreeFamCALM3
HOVERGENP62158
HOGENOMP62158
Homologs : HomoloGeneCALM3
Homology/Alignments : Family Browser (UCSC)CALM3
Gene fusions - Rearrangements
Tumor Fusion PortalCALM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCALM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CALM3
dbVarCALM3
ClinVarCALM3
1000_GenomesCALM3 
Exome Variant ServerCALM3
ExAC (Exome Aggregation Consortium)ENSG00000160014
GNOMAD BrowserENSG00000160014
Genetic variants : HAPMAP808
Genomic Variants (DGV)CALM3 [DGVbeta]
DECIPHERCALM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCALM3 
Mutations
ICGC Data PortalCALM3 
TCGA Data PortalCALM3 
Broad Tumor PortalCALM3
OASIS PortalCALM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCALM3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCALM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CALM3
DgiDB (Drug Gene Interaction Database)CALM3
DoCM (Curated mutations)CALM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CALM3 (select a term)
intoGenCALM3
Cancer3DCALM3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114183   
Orphanet3525   
DisGeNETCALM3
MedgenCALM3
Genetic Testing Registry CALM3
NextProtP62158 [Medical]
TSGene808
GENETestsCALM3
Target ValidationCALM3
Huge Navigator CALM3 [HugePedia]
snp3D : Map Gene to Disease808
BioCentury BCIQCALM3
ClinGenCALM3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD808
Chemical/Pharm GKB GenePA26042
Clinical trialCALM3
Miscellaneous
canSAR (ICR)CALM3 (select the gene name)
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCALM3
EVEXCALM3
GoPubMedCALM3
iHOPCALM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:05:49 CET 2017

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