CALU (calumenin)

2016-04-01  

Identity

HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 813
MIM: 603420
HGNC: 1458
Ensembl: ENSG00000128595

Variants:

dbSNP: 813
ClinVar: 813
TCGA: ENSG00000128595
COSMIC: CALU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128595ENST00000249364O43852
ENSG00000128595ENST00000249364Q6IAW5
ENSG00000128595ENST00000449187O43852
ENSG00000128595ENST00000449187A0A024R755
ENSG00000128595ENST00000479257O43852
ENSG00000128595ENST00000493278H0Y875
ENSG00000128595ENST00000535011O43852
ENSG00000128595ENST00000542996O43852

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA28660GGCXGenePathwayassociated
PA451906warfarinChemicalClinicalAnnotation, VariantAnnotationambiguousPD19794411, 20200517, 21228733, 25126975
PA452632acenocoumarolChemicalClinicalAnnotationassociatedPD17596133, 29479633

References

Pubmed IDYearTitleCitations
170480072007Association of warfarin dose with genes involved in its action and metabolism.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
170495862007Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.39
197944112010Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients.38
202005172010A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.35
199580902009Genetic determinants of warfarin dosing in the Han-Chinese population.25
259638402015Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors.15
204991362010An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
241362342013Calumenin-15 facilitates filopodia formation by promoting TGF-β superfamily cytokine GDF-15 transcription.11

Citation

Dessen P

CALU (calumenin)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55704/calu