Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CAMK2A (calcium/calmodulin dependent protein kinase II alpha)

Identity

Alias_namesCAMKA
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Alias_symbol (synonym)KIAA0968
CaMKIINalpha
Other alias
HGNC (Hugo) CAMK2A
LocusID (NCBI) 815
Atlas_Id 43181
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 150219491 and ends at 150289840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAMK2A (5q32) / GTF2B (1p22.2)CDC42BPA (1q42.13) / CAMK2A (5q32)KIAA1429 (8q22.1) / CAMK2A (5q32)
KIAA1429 8q22.1 / CAMK2A 5q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAMK2A   1460
Cards
Entrez_Gene (NCBI)CAMK2A  815  calcium/calmodulin dependent protein kinase II alpha
AliasesCAMKA
GeneCards (Weizmann)CAMK2A
Ensembl hg19 (Hinxton)ENSG00000070808 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070808 [Gene_View]  chr5:150219491-150289840 [Contig_View]  CAMK2A [Vega]
ICGC DataPortalENSG00000070808
TCGA cBioPortalCAMK2A
AceView (NCBI)CAMK2A
Genatlas (Paris)CAMK2A
WikiGenes815
SOURCE (Princeton)CAMK2A
Genetics Home Reference (NIH)CAMK2A
Genomic and cartography
GoldenPath hg38 (UCSC)CAMK2A  -     chr5:150219491-150289840 -  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAMK2A  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblCAMK2A - 5q32 [CytoView hg19]  CAMK2A - 5q32 [CytoView hg38]
Mapping of homologs : NCBICAMK2A [Mapview hg19]  CAMK2A [Mapview hg38]
OMIM114078   
Gene and transcription
Genbank (Entrez)AB023185 AF091486 AF145710 AF145711 AK289776
RefSeq transcript (Entrez)NM_015981 NM_171825
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAMK2A
Cluster EST : UnigeneHs.743976 [ NCBI ]
CGAP (NCI)Hs.743976
Alternative Splicing GalleryENSG00000070808
Gene ExpressionCAMK2A [ NCBI-GEO ]   CAMK2A [ EBI - ARRAY_EXPRESS ]   CAMK2A [ SEEK ]   CAMK2A [ MEM ]
Gene Expression Viewer (FireBrowse)CAMK2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)815
GTEX Portal (Tissue expression)CAMK2A
Human Protein AtlasENSG00000070808-CAMK2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQM7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQM7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQM7
Splice isoforms : SwissVarQ9UQM7
PhosPhoSitePlusQ9UQM7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Ca/CaM-dep_prot_kinase-assoc    Kinase-like_dom    NTF2-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CaMKII_AD (PF08332)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08332    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMK2A
DMDM Disease mutations815
Blocks (Seattle)CAMK2A
PDB (SRS)2VZ6    3SOA    5IG3   
PDB (PDBSum)2VZ6    3SOA    5IG3   
PDB (IMB)2VZ6    3SOA    5IG3   
PDB (RSDB)2VZ6    3SOA    5IG3   
Structural Biology KnowledgeBase2VZ6    3SOA    5IG3   
SCOP (Structural Classification of Proteins)2VZ6    3SOA    5IG3   
CATH (Classification of proteins structures)2VZ6    3SOA    5IG3   
SuperfamilyQ9UQM7
Human Protein Atlas [tissue]ENSG00000070808-CAMK2A [tissue]
Peptide AtlasQ9UQM7
HPRD06532
IPIIPI00215715   IPI00550056   IPI00964916   IPI00964596   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQM7
IntAct (EBI)Q9UQM7
FunCoupENSG00000070808
BioGRIDCAMK2A
STRING (EMBL)CAMK2A
ZODIACCAMK2A
Ontologies - Pathways
QuickGOQ9UQM7
Ontology : AmiGOG1/S transition of mitotic cell cycle  MAPK cascade  response to ischemia  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  protein phosphorylation  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  nervous system development  calcium-dependent protein serine/threonine kinase activity  positive regulation of cardiac muscle cell apoptotic process  postsynaptic density  kinase activity  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  cell junction  cell differentiation  endocytic vesicle membrane  glutamate receptor binding  intracellular signal transduction  angiotensin-activated signaling pathway  presynaptic membrane  protein homodimerization activity  neuron projection  positive regulation of GTPase activity  protein autophosphorylation  metal ion binding  regulation of neurotransmitter secretion  regulation of neuronal synaptic plasticity  dendrite morphogenesis  positive regulation of NF-kappaB transcription factor activity  positive regulation of calcium ion transport  interferon-gamma-mediated signaling pathway  regulation of cellular response to heat  regulation of mitochondrial membrane permeability involved in apoptotic process  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  MAPK cascade  response to ischemia  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  protein phosphorylation  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  nervous system development  calcium-dependent protein serine/threonine kinase activity  positive regulation of cardiac muscle cell apoptotic process  postsynaptic density  kinase activity  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  cell junction  cell differentiation  endocytic vesicle membrane  glutamate receptor binding  intracellular signal transduction  angiotensin-activated signaling pathway  presynaptic membrane  protein homodimerization activity  neuron projection  positive regulation of GTPase activity  protein autophosphorylation  metal ion binding  regulation of neurotransmitter secretion  regulation of neuronal synaptic plasticity  dendrite morphogenesis  positive regulation of NF-kappaB transcription factor activity  positive regulation of calcium ion transport  interferon-gamma-mediated signaling pathway  regulation of cellular response to heat  regulation of mitochondrial membrane permeability involved in apoptotic process  
Pathways : KEGG   
NDEx NetworkCAMK2A
Atlas of Cancer Signalling NetworkCAMK2A
Wikipedia pathwaysCAMK2A
Orthology - Evolution
OrthoDB815
GeneTree (enSembl)ENSG00000070808
Phylogenetic Trees/Animal Genes : TreeFamCAMK2A
HOVERGENQ9UQM7
HOGENOMQ9UQM7
Homologs : HomoloGeneCAMK2A
Homology/Alignments : Family Browser (UCSC)CAMK2A
Gene fusions - Rearrangements
Fusion : MitelmanKIAA1429/CAMK2A [8q22.1/5q32]  [t(5;8)(q32;q22)]  
Fusion: TCGA_MDACCKIAA1429 8q22.1 CAMK2A 5q32 BRCA
Tumor Fusion PortalCAMK2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMK2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMK2A
dbVarCAMK2A
ClinVarCAMK2A
1000_GenomesCAMK2A 
Exome Variant ServerCAMK2A
ExAC (Exome Aggregation Consortium)ENSG00000070808
GNOMAD BrowserENSG00000070808
Genetic variants : HAPMAP815
Genomic Variants (DGV)CAMK2A [DGVbeta]
DECIPHERCAMK2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAMK2A 
Mutations
ICGC Data PortalCAMK2A 
TCGA Data PortalCAMK2A 
Broad Tumor PortalCAMK2A
OASIS PortalCAMK2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMK2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAMK2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAMK2A
DgiDB (Drug Gene Interaction Database)CAMK2A
DoCM (Curated mutations)CAMK2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAMK2A (select a term)
intoGenCAMK2A
Cancer3DCAMK2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114078   
Orphanet
DisGeNETCAMK2A
MedgenCAMK2A
Genetic Testing Registry CAMK2A
NextProtQ9UQM7 [Medical]
TSGene815
GENETestsCAMK2A
Target ValidationCAMK2A
Huge Navigator CAMK2A [HugePedia]
snp3D : Map Gene to Disease815
BioCentury BCIQCAMK2A
ClinGenCAMK2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD815
Chemical/Pharm GKB GenePA90
Clinical trialCAMK2A
Miscellaneous
canSAR (ICR)CAMK2A (select the gene name)
Probes
Litterature
PubMed161 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAMK2A
EVEXCAMK2A
GoPubMedCAMK2A
iHOPCAMK2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:05:51 CET 2017

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