Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CAMK2D (calcium/calmodulin dependent protein kinase II delta)

Identity

Alias_namesCAMKD
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
Other alias
HGNC (Hugo) CAMK2D
LocusID (NCBI) 817
Atlas_Id 43183
Location 4q26  [Link to chromosome band 4q26]
Location_base_pair Starts at 114372188 and ends at 114683083 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAMK2D (4q26) / ANK2 (4q25)CAMK2D (4q26) / CAMK2D (4q26)CAMK2D (4q26) / COPS7B (2q37.1)
CAMK2D (4q26) / IQGAP1 (15q26.1)CAMK2D 4q26 / ANK2 4q25

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAMK2D   1462
Cards
Entrez_Gene (NCBI)CAMK2D  817  calcium/calmodulin dependent protein kinase II delta
AliasesCAMKD
GeneCards (Weizmann)CAMK2D
Ensembl hg19 (Hinxton)ENSG00000145349 [Gene_View]  chr4:114372188-114683083 [Contig_View]  CAMK2D [Vega]
Ensembl hg38 (Hinxton)ENSG00000145349 [Gene_View]  chr4:114372188-114683083 [Contig_View]  CAMK2D [Vega]
ICGC DataPortalENSG00000145349
TCGA cBioPortalCAMK2D
AceView (NCBI)CAMK2D
Genatlas (Paris)CAMK2D
WikiGenes817
SOURCE (Princeton)CAMK2D
Genetics Home Reference (NIH)CAMK2D
Genomic and cartography
GoldenPath hg19 (UCSC)CAMK2D  -     chr4:114372188-114683083 -  4q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CAMK2D  -     4q26   [Description]    (hg38-Dec_2013)
EnsemblCAMK2D - 4q26 [CytoView hg19]  CAMK2D - 4q26 [CytoView hg38]
Mapping of homologs : NCBICAMK2D [Mapview hg19]  CAMK2D [Mapview hg38]
OMIM607708   
Gene and transcription
Genbank (Entrez)AB209288 AF071569 AI004608 AI057019 AJ252239
RefSeq transcript (Entrez)NM_001221 NM_001321566 NM_001321567 NM_001321568 NM_001321569 NM_001321570 NM_001321571 NM_001321572 NM_001321573 NM_001321574 NM_001321575 NM_001321576 NM_001321577 NM_001321578 NM_001321579 NM_001321580 NM_001321581 NM_001321582 NM_001321583 NM_001321584 NM_001321585 NM_001321586 NM_001321587 NM_001321588 NM_001321589 NM_001321590 NM_001321591 NM_001321592 NM_172114 NM_172115 NM_172127 NM_172128 NM_172129
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CAMK2D
Cluster EST : UnigeneHs.144114 [ NCBI ]
CGAP (NCI)Hs.144114
Alternative Splicing GalleryENSG00000145349
Gene ExpressionCAMK2D [ NCBI-GEO ]   CAMK2D [ EBI - ARRAY_EXPRESS ]   CAMK2D [ SEEK ]   CAMK2D [ MEM ]
Gene Expression Viewer (FireBrowse)CAMK2D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)817
GTEX Portal (Tissue expression)CAMK2D
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13557   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13557  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13557
Splice isoforms : SwissVarQ13557
PhosPhoSitePlusQ13557
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Ca/CaM-dep_prot_kinase-assoc    Kinase-like_dom    NTF2-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CaMKII_AD (PF08332)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08332    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMK2D
DMDM Disease mutations817
Blocks (Seattle)CAMK2D
PDB (SRS)2VN9    2W2C    2WEL    3GP2   
PDB (PDBSum)2VN9    2W2C    2WEL    3GP2   
PDB (IMB)2VN9    2W2C    2WEL    3GP2   
PDB (RSDB)2VN9    2W2C    2WEL    3GP2   
Structural Biology KnowledgeBase2VN9    2W2C    2WEL    3GP2   
SCOP (Structural Classification of Proteins)2VN9    2W2C    2WEL    3GP2   
CATH (Classification of proteins structures)2VN9    2W2C    2WEL    3GP2   
SuperfamilyQ13557
Human Protein AtlasENSG00000145349
Peptide AtlasQ13557
HPRD09653
IPIIPI00430291   IPI00827573   IPI00827625   IPI00876923   IPI00827717   IPI00654569   IPI00828139   IPI00828178   IPI00172636   IPI00827606   IPI00967869   IPI00965234   IPI00964936   IPI00967589   
Protein Interaction databases
DIP (DOE-UCLA)Q13557
IntAct (EBI)Q13557
FunCoupENSG00000145349
BioGRIDCAMK2D
STRING (EMBL)CAMK2D
ZODIACCAMK2D
Ontologies - Pathways
QuickGOQ13557
Ontology : AmiGOG1/S transition of mitotic cell cycle  MAPK cascade  regulation of cell growth  response to hypoxia  regulation of the force of heart contraction  regulation of membrane depolarization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  calcium ion transport  regulation of heart contraction  regulation of G2/M transition of mitotic cell cycle  positive regulation of cardiac muscle hypertrophy  regulation of cell communication by electrical coupling  positive regulation of cardiac muscle cell apoptotic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  intercalated disc  positive regulation of smooth muscle cell migration  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sodium channel inhibitor activity  cellular potassium ion homeostasis  T-tubule  endocytic vesicle membrane  titin binding  neuromuscular junction  endoplasmic reticulum calcium ion homeostasis  sarcoplasmic reticulum membrane  calcium channel complex  positive regulation of Rac protein signal transduction  protein homodimerization activity  neuronal cell body  axon initial segment  positive regulation of GTPase activity  ion channel binding  ion channel binding  protein autophosphorylation  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  nitric-oxide synthase binding  protein oligomerization  relaxation of cardiac muscle  regulation of ryanodine-sensitive calcium-release channel activity  interferon-gamma-mediated signaling pathway  regulation of cellular localization  cell growth involved in cardiac muscle cell development  positive regulation of ERK1 and ERK2 cascade  cellular response to calcium ion  cardiac muscle cell contraction  regulation of heart rate by cardiac conduction  regulation of cardiac muscle cell action potential  regulation of cardiac muscle cell action potential involved in regulation of contraction  regulation of cellular response to heat  regulation of histone deacetylase activity  regulation of cell communication by electrical coupling involved in cardiac conduction  regulation of relaxation of cardiac muscle  negative regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  negative regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  MAPK cascade  regulation of cell growth  response to hypoxia  regulation of the force of heart contraction  regulation of membrane depolarization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  calcium ion transport  regulation of heart contraction  regulation of G2/M transition of mitotic cell cycle  positive regulation of cardiac muscle hypertrophy  regulation of cell communication by electrical coupling  positive regulation of cardiac muscle cell apoptotic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  intercalated disc  positive regulation of smooth muscle cell migration  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sodium channel inhibitor activity  cellular potassium ion homeostasis  T-tubule  endocytic vesicle membrane  titin binding  neuromuscular junction  endoplasmic reticulum calcium ion homeostasis  sarcoplasmic reticulum membrane  calcium channel complex  positive regulation of Rac protein signal transduction  protein homodimerization activity  neuronal cell body  axon initial segment  positive regulation of GTPase activity  ion channel binding  ion channel binding  protein autophosphorylation  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  nitric-oxide synthase binding  protein oligomerization  relaxation of cardiac muscle  regulation of ryanodine-sensitive calcium-release channel activity  interferon-gamma-mediated signaling pathway  regulation of cellular localization  cell growth involved in cardiac muscle cell development  positive regulation of ERK1 and ERK2 cascade  cellular response to calcium ion  cardiac muscle cell contraction  regulation of heart rate by cardiac conduction  regulation of cardiac muscle cell action potential  regulation of cardiac muscle cell action potential involved in regulation of contraction  regulation of cellular response to heat  regulation of histone deacetylase activity  regulation of cell communication by electrical coupling involved in cardiac conduction  regulation of relaxation of cardiac muscle  negative regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  negative regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGErbB signaling pathway    Calcium signaling pathway    HIF-1 signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Wnt signaling pathway    Circadian entrainment    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Dopaminergic synapse    Olfactory transduction    Insulin secretion    GnRH signaling pathway    Melanogenesis    Gastric acid secretion    Amphetamine addiction    Tuberculosis    Proteoglycans in cancer    Glioma   
NDEx NetworkCAMK2D
Atlas of Cancer Signalling NetworkCAMK2D
Wikipedia pathwaysCAMK2D
Orthology - Evolution
OrthoDB817
GeneTree (enSembl)ENSG00000145349
Phylogenetic Trees/Animal Genes : TreeFamCAMK2D
HOVERGENQ13557
HOGENOMQ13557
Homologs : HomoloGeneCAMK2D
Homology/Alignments : Family Browser (UCSC)CAMK2D
Gene fusions - Rearrangements
Fusion: TCGACAMK2D 4q26 ANK2 4q25 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMK2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMK2D
dbVarCAMK2D
ClinVarCAMK2D
1000_GenomesCAMK2D 
Exome Variant ServerCAMK2D
ExAC (Exome Aggregation Consortium)CAMK2D (select the gene name)
Genetic variants : HAPMAP817
Genomic Variants (DGV)CAMK2D [DGVbeta]
DECIPHER (Syndromes)4:114372188-114683083  ENSG00000145349
CONAN: Copy Number AnalysisCAMK2D 
Mutations
ICGC Data PortalCAMK2D 
TCGA Data PortalCAMK2D 
Broad Tumor PortalCAMK2D
OASIS PortalCAMK2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMK2D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAMK2D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAMK2D
DgiDB (Drug Gene Interaction Database)CAMK2D
DoCM (Curated mutations)CAMK2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAMK2D (select a term)
intoGenCAMK2D
Cancer3DCAMK2D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607708   
Orphanet
MedgenCAMK2D
Genetic Testing Registry CAMK2D
NextProtQ13557 [Medical]
TSGene817
GENETestsCAMK2D
Huge Navigator CAMK2D [HugePedia]
snp3D : Map Gene to Disease817
BioCentury BCIQCAMK2D
ClinGenCAMK2D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD817
Chemical/Pharm GKB GenePA92
Clinical trialCAMK2D
Miscellaneous
canSAR (ICR)CAMK2D (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAMK2D
EVEXCAMK2D
GoPubMedCAMK2D
iHOPCAMK2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:54:55 CEST 2017

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