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CAMK2D (calcium/calmodulin dependent protein kinase II delta)

Identity

Alias (NCBI)CAMKD
HGNC (Hugo) CAMK2D
HGNC Previous nameCAMKD
HGNC Previous namecalcium/calmodulin-dependent protein kinase (CaM kinase) II delta
LocusID (NCBI) 817
Atlas_Id 43183
Location 4q26  [Link to chromosome band 4q26]
Location_base_pair Starts at 113457188 and ends at 113761927 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAMK2D (4q26) / ANK2 (4q25)CAMK2D (4q26) / CAMK2D (4q26)CAMK2D (4q26) / COPS7B (2q37.1)
CAMK2D (4q26) / IQGAP1 (15q26.1)CAMK2D 4q26 / ANK2 4q25

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CAMK2D   1462
Cards
Entrez_Gene (NCBI)CAMK2D    calcium/calmodulin dependent protein kinase II delta
AliasesCAMKD
GeneCards (Weizmann)CAMK2D
Ensembl hg19 (Hinxton)ENSG00000145349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145349 [Gene_View]  ENSG00000145349 [Sequence]  chr4:113457188-113761927 [Contig_View]  CAMK2D [Vega]
ICGC DataPortalENSG00000145349
TCGA cBioPortalCAMK2D
AceView (NCBI)CAMK2D
Genatlas (Paris)CAMK2D
SOURCE (Princeton)CAMK2D
Genetics Home Reference (NIH)CAMK2D
Genomic and cartography
GoldenPath hg38 (UCSC)CAMK2D  -     chr4:113457188-113761927 -  4q26   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAMK2D  -     4q26   [Description]    (hg19-Feb_2009)
GoldenPathCAMK2D - 4q26 [CytoView hg19]  CAMK2D - 4q26 [CytoView hg38]
ImmunoBaseENSG00000145349
Genome Data Viewer NCBICAMK2D [Mapview hg19]  
OMIM607708   
Gene and transcription
Genbank (Entrez)AB209288 AF071569 AI004608 AI057019 AJ252239
RefSeq transcript (Entrez)NM_001221 NM_001321566 NM_001321567 NM_001321568 NM_001321569 NM_001321570 NM_001321571 NM_001321572 NM_001321573 NM_001321574 NM_001321575 NM_001321576 NM_001321577 NM_001321578 NM_001321579 NM_001321580 NM_001321581 NM_001321582 NM_001321583 NM_001321584 NM_001321585 NM_001321586 NM_001321587 NM_001321588 NM_001321589 NM_001321590 NM_001321591 NM_001321592 NM_172114 NM_172115 NM_172127 NM_172128 NM_172129
Consensus coding sequences : CCDS (NCBI)CAMK2D
Gene ExpressionCAMK2D [ NCBI-GEO ]   CAMK2D [ EBI - ARRAY_EXPRESS ]   CAMK2D [ SEEK ]   CAMK2D [ MEM ]
Gene Expression Viewer (FireBrowse)CAMK2D [ Firebrowse - Broad ]
GenevisibleExpression of CAMK2D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)817
GTEX Portal (Tissue expression)CAMK2D
Human Protein AtlasENSG00000145349-CAMK2D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13557   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13557  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13557
PhosPhoSitePlusQ13557
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_prot_kinase-assoc    Kinase-like_dom_sf    NTF2-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CaMKII_AD (PF08332)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08332    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMK2D
PDB (RSDB)2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
PDB Europe2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
PDB (PDBSum)2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
PDB (IMB)2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
Structural Biology KnowledgeBase2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
SCOP (Structural Classification of Proteins)2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
CATH (Classification of proteins structures)2VN9    2W2C    2WEL    3GP2    5VLO    6AYW   
SuperfamilyQ13557
AlphaFold pdb e-kbQ13557   
Human Protein Atlas [tissue]ENSG00000145349-CAMK2D [tissue]
HPRD09653
Protein Interaction databases
DIP (DOE-UCLA)Q13557
IntAct (EBI)Q13557
BioGRIDCAMK2D
STRING (EMBL)CAMK2D
ZODIACCAMK2D
Ontologies - Pathways
QuickGOQ13557
Ontology : AmiGOregulation of cell growth  regulation of the force of heart contraction  regulation of membrane depolarization  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  calcium- and calmodulin-dependent protein kinase complex  regulation of transcription by RNA polymerase II  protein phosphorylation  regulation of heart contraction  positive regulation of cardiac muscle hypertrophy  regulation of cell communication by electrical coupling  positive regulation of cardiac muscle cell apoptotic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sodium channel inhibitor activity  endocytic vesicle membrane  titin binding  endoplasmic reticulum calcium ion homeostasis  sarcoplasmic reticulum membrane  sarcolemma  identical protein binding  protein homodimerization activity  neuron projection  ion channel binding  ion channel binding  protein autophosphorylation  relaxation of cardiac muscle  regulation of ryanodine-sensitive calcium-release channel activity  interferon-gamma-mediated signaling pathway  regulation of cellular localization  cellular response to calcium ion  cardiac muscle cell contraction  regulation of heart rate by cardiac conduction  regulation of cardiac muscle cell action potential  regulation of cardiac muscle cell action potential involved in regulation of contraction  protein serine kinase activity  protein threonine kinase activity  regulation of cellular response to heat  regulation of histone deacetylase activity  regulation of cell communication by electrical coupling involved in cardiac conduction  regulation of relaxation of cardiac muscle  negative regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  negative regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIregulation of cell growth  regulation of the force of heart contraction  regulation of membrane depolarization  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  calcium- and calmodulin-dependent protein kinase complex  regulation of transcription by RNA polymerase II  protein phosphorylation  regulation of heart contraction  positive regulation of cardiac muscle hypertrophy  regulation of cell communication by electrical coupling  positive regulation of cardiac muscle cell apoptotic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sodium channel inhibitor activity  endocytic vesicle membrane  titin binding  endoplasmic reticulum calcium ion homeostasis  sarcoplasmic reticulum membrane  sarcolemma  identical protein binding  protein homodimerization activity  neuron projection  ion channel binding  ion channel binding  protein autophosphorylation  relaxation of cardiac muscle  regulation of ryanodine-sensitive calcium-release channel activity  interferon-gamma-mediated signaling pathway  regulation of cellular localization  cellular response to calcium ion  cardiac muscle cell contraction  regulation of heart rate by cardiac conduction  regulation of cardiac muscle cell action potential  regulation of cardiac muscle cell action potential involved in regulation of contraction  protein serine kinase activity  protein threonine kinase activity  regulation of cellular response to heat  regulation of histone deacetylase activity  regulation of cell communication by electrical coupling involved in cardiac conduction  regulation of relaxation of cardiac muscle  negative regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  negative regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGErbB signaling pathway    Calcium signaling pathway    HIF-1 signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Wnt signaling pathway    Circadian entrainment    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Dopaminergic synapse    Olfactory transduction    Insulin secretion    GnRH signaling pathway    Melanogenesis    Gastric acid secretion    Amphetamine addiction    Tuberculosis    Proteoglycans in cancer    Glioma   
NDEx NetworkCAMK2D
Atlas of Cancer Signalling NetworkCAMK2D
Wikipedia pathwaysCAMK2D
Orthology - Evolution
OrthoDB817
GeneTree (enSembl)ENSG00000145349
Phylogenetic Trees/Animal Genes : TreeFamCAMK2D
Homologs : HomoloGeneCAMK2D
Homology/Alignments : Family Browser (UCSC)CAMK2D
Gene fusions - Rearrangements
Fusion : QuiverCAMK2D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMK2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMK2D
dbVarCAMK2D
ClinVarCAMK2D
MonarchCAMK2D
1000_GenomesCAMK2D 
Exome Variant ServerCAMK2D
GNOMAD BrowserENSG00000145349
Varsome BrowserCAMK2D
ACMGCAMK2D variants
VarityQ13557
Genomic Variants (DGV)CAMK2D [DGVbeta]
DECIPHERCAMK2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAMK2D 
Mutations
ICGC Data PortalCAMK2D 
TCGA Data PortalCAMK2D 
Broad Tumor PortalCAMK2D
OASIS PortalCAMK2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMK2D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCAMK2D
Mutations and Diseases : HGMDCAMK2D
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCAMK2D
DgiDB (Drug Gene Interaction Database)CAMK2D
DoCM (Curated mutations)CAMK2D
CIViC (Clinical Interpretations of Variants in Cancer)CAMK2D
Cancer3DCAMK2D
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607708   
Orphanet
DisGeNETCAMK2D
MedgenCAMK2D
Genetic Testing Registry CAMK2D
NextProtQ13557 [Medical]
GENETestsCAMK2D
Target ValidationCAMK2D
Huge Navigator CAMK2D [HugePedia]
ClinGenCAMK2D
Clinical trials, drugs, therapy
MyCancerGenomeCAMK2D
Protein Interactions : CTDCAMK2D
Pharm GKB GenePA92
Pharm GKB PathwaysPA162356267   
PharosQ13557
Clinical trialCAMK2D
Miscellaneous
canSAR (ICR)CAMK2D
HarmonizomeCAMK2D
DataMed IndexCAMK2D
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCAMK2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:07 CEST 2021

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