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CAMK4 (calcium/calmodulin dependent protein kinase IV)

Identity

Alias_symbol (synonym)CaMK-GR
Other aliasCaMK IV
caMK
HGNC (Hugo) CAMK4
LocusID (NCBI) 814
Atlas_Id 906
Location 5q22.1  [Link to chromosome band 5q22]
Location_base_pair Starts at 111223950 and ends at 111494884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAMK4 (5q22.1) / SPATA22 (17p13.2)FHIT (3p14.2) / CAMK4 (5q22.1)HLA-B (6p21.33) / CAMK4 (5q22.1)
FHIT 3p14.2 / CAMK4 5q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAMK4   1464
Cards
Entrez_Gene (NCBI)CAMK4  814  calcium/calmodulin dependent protein kinase IV
AliasesCaMK; CaMK-GR; caMK
GeneCards (Weizmann)CAMK4
Ensembl hg19 (Hinxton)ENSG00000152495 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152495 [Gene_View]  chr5:111223950-111494884 [Contig_View]  CAMK4 [Vega]
ICGC DataPortalENSG00000152495
TCGA cBioPortalCAMK4
AceView (NCBI)CAMK4
Genatlas (Paris)CAMK4
WikiGenes814
SOURCE (Princeton)CAMK4
Genetics Home Reference (NIH)CAMK4
Genomic and cartography
GoldenPath hg38 (UCSC)CAMK4  -     chr5:111223950-111494884 +  5q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAMK4  -     5q22.1   [Description]    (hg19-Feb_2009)
EnsemblCAMK4 - 5q22.1 [CytoView hg19]  CAMK4 - 5q22.1 [CytoView hg38]
Mapping of homologs : NCBICAMK4 [Mapview hg19]  CAMK4 [Mapview hg38]
OMIM114080   
Gene and transcription
Genbank (Entrez)AK311662 AK312840 AL833368 BC016695 BC025687
RefSeq transcript (Entrez)NM_001323374 NM_001323375 NM_001323376 NM_001323377 NM_001744
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAMK4
Cluster EST : UnigeneHs.591269 [ NCBI ]
CGAP (NCI)Hs.591269
Alternative Splicing GalleryENSG00000152495
Gene ExpressionCAMK4 [ NCBI-GEO ]   CAMK4 [ EBI - ARRAY_EXPRESS ]   CAMK4 [ SEEK ]   CAMK4 [ MEM ]
Gene Expression Viewer (FireBrowse)CAMK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)814
GTEX Portal (Tissue expression)CAMK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16566   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16566
Splice isoforms : SwissVarQ16566
Catalytic activity : Enzyme2.7.11.17 [ Enzyme-Expasy ]   2.7.11.172.7.11.17 [ IntEnz-EBI ]   2.7.11.17 [ BRENDA ]   2.7.11.17 [ KEGG ]   
PhosPhoSitePlusQ16566
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMK4
DMDM Disease mutations814
Blocks (Seattle)CAMK4
PDB (SRS)2W4O   
PDB (PDBSum)2W4O   
PDB (IMB)2W4O   
PDB (RSDB)2W4O   
Structural Biology KnowledgeBase2W4O   
SCOP (Structural Classification of Proteins)2W4O   
CATH (Classification of proteins structures)2W4O   
SuperfamilyQ16566
Human Protein AtlasENSG00000152495
Peptide AtlasQ16566
HPRD07169
IPIIPI00430411   IPI00965202   IPI00965910   IPI00965420   
Protein Interaction databases
DIP (DOE-UCLA)Q16566
IntAct (EBI)Q16566
FunCoupENSG00000152495
BioGRIDCAMK4
STRING (EMBL)CAMK4
ZODIACCAMK4
Ontologies - Pathways
QuickGOQ16566
Ontology : AmiGOfibrillar center  adaptive immune response  myeloid dendritic cell cytokine production  calmodulin-dependent protein kinase activity  calmodulin binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  inflammatory response  signal transduction  long-term memory  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  regulation of T cell differentiation in thymus  intracellular signal transduction  myeloid dendritic cell differentiation  regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  protein autophosphorylation  extracellular exosome  
Ontology : EGO-EBIfibrillar center  adaptive immune response  myeloid dendritic cell cytokine production  calmodulin-dependent protein kinase activity  calmodulin binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  inflammatory response  signal transduction  long-term memory  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  regulation of T cell differentiation in thymus  intracellular signal transduction  myeloid dendritic cell differentiation  regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  protein autophosphorylation  extracellular exosome  
Pathways : BIOCARTARegulation of PGC-1a [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Ca++/ Calmodulin-dependent Protein Kinase Activation [Genes]    Stathmin and breast cancer resistance to antimicrotubule agents [Genes]   
Pathways : KEGGCalcium signaling pathway    Osteoclast differentiation    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Amphetamine addiction    Alcoholism   
NDEx NetworkCAMK4
Atlas of Cancer Signalling NetworkCAMK4
Wikipedia pathwaysCAMK4
Orthology - Evolution
OrthoDB814
GeneTree (enSembl)ENSG00000152495
Phylogenetic Trees/Animal Genes : TreeFamCAMK4
HOVERGENQ16566
HOGENOMQ16566
Homologs : HomoloGeneCAMK4
Homology/Alignments : Family Browser (UCSC)CAMK4
Gene fusions - Rearrangements
Fusion : MitelmanFHIT/CAMK4 [3p14.2/5q22.1]  [t(3;5)(p14;q22)]  
Fusion: TCGAFHIT 3p14.2 CAMK4 5q22.1 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMK4
dbVarCAMK4
ClinVarCAMK4
1000_GenomesCAMK4 
Exome Variant ServerCAMK4
ExAC (Exome Aggregation Consortium)CAMK4 (select the gene name)
Genetic variants : HAPMAP814
Genomic Variants (DGV)CAMK4 [DGVbeta]
DECIPHERCAMK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAMK4 
Mutations
ICGC Data PortalCAMK4 
TCGA Data PortalCAMK4 
Broad Tumor PortalCAMK4
OASIS PortalCAMK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAMK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAMK4
DgiDB (Drug Gene Interaction Database)CAMK4
DoCM (Curated mutations)CAMK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAMK4 (select a term)
intoGenCAMK4
Cancer3DCAMK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114080   
Orphanet
MedgenCAMK4
Genetic Testing Registry CAMK4
NextProtQ16566 [Medical]
TSGene814
GENETestsCAMK4
Target ValidationCAMK4
Huge Navigator CAMK4 [HugePedia]
snp3D : Map Gene to Disease814
BioCentury BCIQCAMK4
ClinGenCAMK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD814
Chemical/Pharm GKB GenePA26050
Clinical trialCAMK4
Miscellaneous
canSAR (ICR)CAMK4 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAMK4
EVEXCAMK4
GoPubMedCAMK4
iHOPCAMK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:56:44 CEST 2017

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