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CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)

Identity

Alias_namescalcium/calmodulin-dependent protein kinase kinase 1
Alias_symbol (synonym)DKFZp761M0423
CAMKKA
MGC34095
Other alias
HGNC (Hugo) CAMKK1
LocusID (NCBI) 84254
Atlas_Id 43185
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3860323 and ends at 3893043 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAMKK1 (17p13.2) / CAMKK1 (17p13.2)MAP2K2 (19p13.3) / CAMKK1 (17p13.2)NCBP3 (17p13.2) / CAMKK1 (17p13.2)
C17orf85 17p13.2 / CAMKK1 17p13.2MAP2K2 19p13.3 / CAMKK1 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAMKK1   1469
Cards
Entrez_Gene (NCBI)CAMKK1  84254  calcium/calmodulin dependent protein kinase kinase 1
AliasesCAMKKA
GeneCards (Weizmann)CAMKK1
Ensembl hg19 (Hinxton)ENSG00000004660 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004660 [Gene_View]  chr17:3860323-3893043 [Contig_View]  CAMKK1 [Vega]
ICGC DataPortalENSG00000004660
TCGA cBioPortalCAMKK1
AceView (NCBI)CAMKK1
Genatlas (Paris)CAMKK1
WikiGenes84254
SOURCE (Princeton)CAMKK1
Genetics Home Reference (NIH)CAMKK1
Genomic and cartography
GoldenPath hg38 (UCSC)CAMKK1  -     chr17:3860323-3893043 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAMKK1  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblCAMKK1 - 17p13.2 [CytoView hg19]  CAMKK1 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBICAMKK1 [Mapview hg19]  CAMKK1 [Mapview hg38]
OMIM611411   
Gene and transcription
Genbank (Entrez)AF370377 AF425232 AF425301 AK128601 AL136576
RefSeq transcript (Entrez)NM_032294 NM_172206 NM_172207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAMKK1
Cluster EST : UnigeneHs.8417 [ NCBI ]
CGAP (NCI)Hs.8417
Alternative Splicing GalleryENSG00000004660
Gene ExpressionCAMKK1 [ NCBI-GEO ]   CAMKK1 [ EBI - ARRAY_EXPRESS ]   CAMKK1 [ SEEK ]   CAMKK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CAMKK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84254
GTEX Portal (Tissue expression)CAMKK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N5S9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N5S9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N5S9
Splice isoforms : SwissVarQ8N5S9
Catalytic activity : Enzyme2.7.11.17 [ Enzyme-Expasy ]   2.7.11.172.7.11.17 [ IntEnz-EBI ]   2.7.11.17 [ BRENDA ]   2.7.11.17 [ KEGG ]   
PhosPhoSitePlusQ8N5S9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMKK1
DMDM Disease mutations84254
Blocks (Seattle)CAMKK1
SuperfamilyQ8N5S9
Human Protein AtlasENSG00000004660
Peptide AtlasQ8N5S9
HPRD13000
IPIIPI00017083   IPI00166909   IPI00792960   IPI00435971   IPI00657696   
Protein Interaction databases
DIP (DOE-UCLA)Q8N5S9
IntAct (EBI)Q8N5S9
FunCoupENSG00000004660
BioGRIDCAMKK1
STRING (EMBL)CAMKK1
ZODIACCAMKK1
Ontologies - Pathways
QuickGOQ8N5S9
Ontology : AmiGOcalmodulin-dependent protein kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  positive regulation of protein kinase activity  
Ontology : EGO-EBIcalmodulin-dependent protein kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  positive regulation of protein kinase activity  
Pathways : BIOCARTACa++/ Calmodulin-dependent Protein Kinase Activation [Genes]   
Pathways : KEGGAdipocytokine signaling pathway    Alcoholism   
NDEx NetworkCAMKK1
Atlas of Cancer Signalling NetworkCAMKK1
Wikipedia pathwaysCAMKK1
Orthology - Evolution
OrthoDB84254
GeneTree (enSembl)ENSG00000004660
Phylogenetic Trees/Animal Genes : TreeFamCAMKK1
HOVERGENQ8N5S9
HOGENOMQ8N5S9
Homologs : HomoloGeneCAMKK1
Homology/Alignments : Family Browser (UCSC)CAMKK1
Gene fusions - Rearrangements
Fusion : MitelmanC17orf85/CAMKK1 [17p13.2/17p13.2]  [t(17;17)(p13;p13)]  
Fusion : MitelmanMAP2K2/CAMKK1 [19p13.3/17p13.2]  [t(17;19)(p13;p13)]  
Fusion: TCGAC17orf85 17p13.2 CAMKK1 17p13.2 BRCA
Fusion: TCGAMAP2K2 19p13.3 CAMKK1 17p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMKK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMKK1
dbVarCAMKK1
ClinVarCAMKK1
1000_GenomesCAMKK1 
Exome Variant ServerCAMKK1
ExAC (Exome Aggregation Consortium)CAMKK1 (select the gene name)
Genetic variants : HAPMAP84254
Genomic Variants (DGV)CAMKK1 [DGVbeta]
DECIPHERCAMKK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAMKK1 
Mutations
ICGC Data PortalCAMKK1 
TCGA Data PortalCAMKK1 
Broad Tumor PortalCAMKK1
OASIS PortalCAMKK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMKK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAMKK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAMKK1
DgiDB (Drug Gene Interaction Database)CAMKK1
DoCM (Curated mutations)CAMKK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAMKK1 (select a term)
intoGenCAMKK1
Cancer3DCAMKK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611411   
Orphanet
MedgenCAMKK1
Genetic Testing Registry CAMKK1
NextProtQ8N5S9 [Medical]
TSGene84254
GENETestsCAMKK1
Target ValidationCAMKK1
Huge Navigator CAMKK1 [HugePedia]
snp3D : Map Gene to Disease84254
BioCentury BCIQCAMKK1
ClinGenCAMKK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84254
Chemical/Pharm GKB GenePA26051
Clinical trialCAMKK1
Miscellaneous
canSAR (ICR)CAMKK1 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAMKK1
EVEXCAMKK1
GoPubMedCAMKK1
iHOPCAMKK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:26:36 CEST 2017

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