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CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2)

Identity

Alias_namescalcium/calmodulin-dependent protein kinase kinase 2
Alias_symbol (synonym)CAMKK
KIAA0787
CAMKKB
MGC15254
Other alias
HGNC (Hugo) CAMKK2
LocusID (NCBI) 10645
Atlas_Id 43186
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 121237692 and ends at 121296753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / CAMKK2 (12q24.31)CAMKK2 (12q24.31) / KCNK5 (6p21.2)CAMKK2 (12q24.31) / NR2C1 (12q22)
CAMKK2 (12q24.31) / PIP5K1A (1q21.3)CAMKK2 (12q24.31) / PRKRIP1 (7q22.1)HSPB1 (7q11.23) / CAMKK2 (12q24.31)
LRRC23 (12p13.31) / CAMKK2 (12q24.31)CAMKK2 12q24.31 / NR2C1 12q22HSPB1 7q11.23 / CAMKK2 12q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAMKK2   1470
Cards
Entrez_Gene (NCBI)CAMKK2  10645  calcium/calmodulin dependent protein kinase kinase 2
AliasesCAMKK; CAMKKB
GeneCards (Weizmann)CAMKK2
Ensembl hg19 (Hinxton)ENSG00000110931 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110931 [Gene_View]  chr12:121237692-121296753 [Contig_View]  CAMKK2 [Vega]
ICGC DataPortalENSG00000110931
TCGA cBioPortalCAMKK2
AceView (NCBI)CAMKK2
Genatlas (Paris)CAMKK2
WikiGenes10645
SOURCE (Princeton)CAMKK2
Genetics Home Reference (NIH)CAMKK2
Genomic and cartography
GoldenPath hg38 (UCSC)CAMKK2  -     chr12:121237692-121296753 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAMKK2  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblCAMKK2 - 12q24.31 [CytoView hg19]  CAMKK2 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBICAMKK2 [Mapview hg19]  CAMKK2 [Mapview hg38]
OMIM615002   
Gene and transcription
Genbank (Entrez)AA678930 AB018330 AB081336 AB081337 AF091074
RefSeq transcript (Entrez)NM_001270485 NM_001270486 NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216 NM_172226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAMKK2
Cluster EST : UnigeneHs.297343 [ NCBI ]
CGAP (NCI)Hs.297343
Alternative Splicing GalleryENSG00000110931
Gene ExpressionCAMKK2 [ NCBI-GEO ]   CAMKK2 [ EBI - ARRAY_EXPRESS ]   CAMKK2 [ SEEK ]   CAMKK2 [ MEM ]
Gene Expression Viewer (FireBrowse)CAMKK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10645
GTEX Portal (Tissue expression)CAMKK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RR4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RR4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RR4
Splice isoforms : SwissVarQ96RR4
Catalytic activity : Enzyme2.7.11.17 [ Enzyme-Expasy ]   2.7.11.172.7.11.17 [ IntEnz-EBI ]   2.7.11.17 [ BRENDA ]   2.7.11.17 [ KEGG ]   
PhosPhoSitePlusQ96RR4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CAMKK2
DMDM Disease mutations10645
Blocks (Seattle)CAMKK2
PDB (SRS)2ZV2   
PDB (PDBSum)2ZV2   
PDB (IMB)2ZV2   
PDB (RSDB)2ZV2   
Structural Biology KnowledgeBase2ZV2   
SCOP (Structural Classification of Proteins)2ZV2   
CATH (Classification of proteins structures)2ZV2   
SuperfamilyQ96RR4
Human Protein AtlasENSG00000110931
Peptide AtlasQ96RR4
HPRD06467
IPIIPI00290239   IPI00172500   IPI00170509   IPI00292156   IPI00172426   IPI00172501   IPI00479420   IPI01012818   IPI00788731   IPI01014052   IPI01012541   IPI00791451   
Protein Interaction databases
DIP (DOE-UCLA)Q96RR4
IntAct (EBI)Q96RR4
FunCoupENSG00000110931
BioGRIDCAMKK2
STRING (EMBL)CAMKK2
ZODIACCAMKK2
Ontologies - Pathways
QuickGOQ96RR4
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  calmodulin-dependent protein kinase activity  protein tyrosine kinase activity  calcium ion binding  calmodulin binding  ATP binding  intracellular  intracellular  nucleus  cytoplasm  cytosol  protein phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  calcium-mediated signaling  cellular response to reactive oxygen species  cell projection  regulation of protein kinase activity  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  protein autophosphorylation  CAMKK-AMPK signaling cascade  positive regulation of mitophagy  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  calmodulin-dependent protein kinase activity  protein tyrosine kinase activity  calcium ion binding  calmodulin binding  ATP binding  intracellular  intracellular  nucleus  cytoplasm  cytosol  protein phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  calcium-mediated signaling  cellular response to reactive oxygen species  cell projection  regulation of protein kinase activity  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  protein autophosphorylation  CAMKK-AMPK signaling cascade  positive regulation of mitophagy  
Pathways : BIOCARTACa++/ Calmodulin-dependent Protein Kinase Activation [Genes]   
Pathways : KEGGAdipocytokine signaling pathway    Alcoholism   
NDEx NetworkCAMKK2
Atlas of Cancer Signalling NetworkCAMKK2
Wikipedia pathwaysCAMKK2
Orthology - Evolution
OrthoDB10645
GeneTree (enSembl)ENSG00000110931
Phylogenetic Trees/Animal Genes : TreeFamCAMKK2
HOVERGENQ96RR4
HOGENOMQ96RR4
Homologs : HomoloGeneCAMKK2
Homology/Alignments : Family Browser (UCSC)CAMKK2
Gene fusions - Rearrangements
Fusion : MitelmanCAMKK2/NR2C1 [12q24.31/12q22]  
Fusion : MitelmanCAMKK2/PRKRIP1 [12q24.31/7q22.1]  [t(7;12)(q22;q24)]  
Fusion : MitelmanHSPB1/CAMKK2 [7q11.23/12q24.31]  [t(7;12)(q11;q24)]  
Fusion: TCGACAMKK2 12q24.31 NR2C1 12q22 GBM
Fusion: TCGAHSPB1 7q11.23 CAMKK2 12q24.31 PRAD
Fusion Cancer (Beijing)AD_1 [CAMKK2]  -  12q24.31 [FUSC002603]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAMKK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAMKK2
dbVarCAMKK2
ClinVarCAMKK2
1000_GenomesCAMKK2 
Exome Variant ServerCAMKK2
ExAC (Exome Aggregation Consortium)CAMKK2 (select the gene name)
Genetic variants : HAPMAP10645
Genomic Variants (DGV)CAMKK2 [DGVbeta]
DECIPHERCAMKK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAMKK2 
Mutations
ICGC Data PortalCAMKK2 
TCGA Data PortalCAMKK2 
Broad Tumor PortalCAMKK2
OASIS PortalCAMKK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAMKK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAMKK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAMKK2
DgiDB (Drug Gene Interaction Database)CAMKK2
DoCM (Curated mutations)CAMKK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAMKK2 (select a term)
intoGenCAMKK2
Cancer3DCAMKK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615002   
Orphanet
MedgenCAMKK2
Genetic Testing Registry CAMKK2
NextProtQ96RR4 [Medical]
TSGene10645
GENETestsCAMKK2
Target ValidationCAMKK2
Huge Navigator CAMKK2 [HugePedia]
snp3D : Map Gene to Disease10645
BioCentury BCIQCAMKK2
ClinGenCAMKK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10645
Chemical/Pharm GKB GenePA26052
Clinical trialCAMKK2
Miscellaneous
canSAR (ICR)CAMKK2 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAMKK2
EVEXCAMKK2
GoPubMedCAMKK2
iHOPCAMKK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:26:37 CEST 2017

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