CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2)

2006-10-01  

Identity

HGNC
CAMKK2
LOCATION
12q24.31
LOCUSID
10645
ALIAS
CAMKK,CAMKKB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10645
MIM: 615002
HGNC: 1470
Ensembl: ENSG00000110931

Variants:

dbSNP: 10645
ClinVar: 10645
TCGA: ENSG00000110931
COSMIC: CAMKK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110931ENST00000324774Q96RR4
ENSG00000110931ENST00000324774A0A024RBQ0
ENSG00000110931ENST00000337174Q96RR4
ENSG00000110931ENST00000337174A0A024RBP6
ENSG00000110931ENST00000347034Q96RR4
ENSG00000110931ENST00000347034A0A024RBP8
ENSG00000110931ENST00000392473Q96RR4
ENSG00000110931ENST00000392474Q96RR4
ENSG00000110931ENST00000402834Q96RR4
ENSG00000110931ENST00000402834A0A024RBQ0
ENSG00000110931ENST00000404169Q96RR4
ENSG00000110931ENST00000404169A0A024RBQ0
ENSG00000110931ENST00000412367Q96RR4
ENSG00000110931ENST00000412367A0A024RBP6
ENSG00000110931ENST00000446440Q96RR4
ENSG00000110931ENST00000538733Q96RR4
ENSG00000110931ENST00000538733A0A024RBQ3
ENSG00000110931ENST00000543477F5H4I7
ENSG00000110931ENST00000544485F5H360
ENSG00000110931ENST00000545538F5GZ00
ENSG00000110931ENST00000652382Q96RR4
ENSG00000110931ENST00000652382A0A024RBQ0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Adipocytokine signaling pathwayKEGGko04920
Autophagy - animalKEGGhsa04140
Adipocytokine signaling pathwayKEGGhsa04920
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
160540952005Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.519
160540962005Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.435
216701472011Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.130
168805062006Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.79
227782632012Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
199582862010Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.57
166733752006Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.52
230278652012Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).39
218070922011Characterization of the CaMKKβ-AMPK signaling complex.33

Citation

Dessen P

CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43186/camkk2