CAMP (cathelicidin antimicrobial peptide)

2007-02-01  

Identity

HGNC
CAMP
LOCATION
3p21.31
LOCUSID
820
ALIAS
CAP-18,CAP18,CRAMP,FALL-39,FALL39,HSD26,LL37
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 820
MIM: 600474
HGNC: 1472
Ensembl: ENSG00000164047

Variants:

dbSNP: 820
ClinVar: 820
TCGA: ENSG00000164047
COSMIC: CAMP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164047ENST00000296435J3KNB4
ENSG00000164047ENST00000652295P49913
ENSG00000164047ENST00000652295A0A384NPR0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164978872006Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.1029
178738602007Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.511
176754632007Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.245
167517682006The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection.205
127826692003An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.197
197039862009Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.183
122441862002The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses.169
127672382003Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37.152
164560052006Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37.149
176760512007Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.148

Citation

Dessen P

CAMP (cathelicidin antimicrobial peptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45737/camp