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CAND1 (cullin associated and neddylation dissociated 1)

Identity

Alias_namescullin-associated and neddylation-dissociated 1
Alias_symbol (synonym)TIP120A
DKFZp434M1414
KIAA0829
TIP120
Other alias
HGNC (Hugo) CAND1
LocusID (NCBI) 55832
Atlas_Id 53172
Location 12q14.3  [Link to chromosome band 12q14]
Location_base_pair Starts at 67269281 and ends at 67314692 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAND1 (12q14.3) / ACSS3 (12q21.31)CAND1 (12q14.3) / EGFR (7p11.2)CAND1 (12q14.3) / GNS (12q14.3)
CAND1 (12q14.3) / PHF13 (1p36.31)CAND1 (12q14.3) / TUSC5 (17p13.3)PORCN (Xp11.23) / CAND1 (12q14.3)
CAND1 12q14.3 / TUSC5 17p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAND1   30688
Cards
Entrez_Gene (NCBI)CAND1  55832  cullin associated and neddylation dissociated 1
AliasesTIP120; TIP120A
GeneCards (Weizmann)CAND1
Ensembl hg19 (Hinxton)ENSG00000111530 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111530 [Gene_View]  chr12:67269281-67314692 [Contig_View]  CAND1 [Vega]
ICGC DataPortalENSG00000111530
TCGA cBioPortalCAND1
AceView (NCBI)CAND1
Genatlas (Paris)CAND1
WikiGenes55832
SOURCE (Princeton)CAND1
Genetics Home Reference (NIH)CAND1
Genomic and cartography
GoldenPath hg38 (UCSC)CAND1  -     chr12:67269281-67314692 +  12q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAND1  -     12q14.3   [Description]    (hg19-Feb_2009)
EnsemblCAND1 - 12q14.3 [CytoView hg19]  CAND1 - 12q14.3 [CytoView hg38]
Mapping of homologs : NCBICAND1 [Mapview hg19]  CAND1 [Mapview hg38]
OMIM607727   
Gene and transcription
Genbank (Entrez)AA766567 AB020636 AF157326 AK000976 AK001791
RefSeq transcript (Entrez)NM_001329674 NM_001329675 NM_001329676 NM_018448
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAND1
Cluster EST : UnigeneHs.546407 [ NCBI ]
CGAP (NCI)Hs.546407
Alternative Splicing GalleryENSG00000111530
Gene ExpressionCAND1 [ NCBI-GEO ]   CAND1 [ EBI - ARRAY_EXPRESS ]   CAND1 [ SEEK ]   CAND1 [ MEM ]
Gene Expression Viewer (FireBrowse)CAND1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55832
GTEX Portal (Tissue expression)CAND1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VP6
Splice isoforms : SwissVarQ86VP6
PhosPhoSitePlusQ86VP6
Domains : Interpro (EBI)ARM-like    ARM-type_fold    TATA-bd_TIP120   
Domain families : Pfam (Sanger)TIP120 (PF08623)   
Domain families : Pfam (NCBI)pfam08623   
Conserved Domain (NCBI)CAND1
DMDM Disease mutations55832
Blocks (Seattle)CAND1
PDB (SRS)1U6G    4A0C   
PDB (PDBSum)1U6G    4A0C   
PDB (IMB)1U6G    4A0C   
PDB (RSDB)1U6G    4A0C   
Structural Biology KnowledgeBase1U6G    4A0C   
SCOP (Structural Classification of Proteins)1U6G    4A0C   
CATH (Classification of proteins structures)1U6G    4A0C   
SuperfamilyQ86VP6
Human Protein AtlasENSG00000111530
Peptide AtlasQ86VP6
HPRD06983
IPIIPI00100160   IPI00604431   IPI00915424   IPI01011449   
Protein Interaction databases
DIP (DOE-UCLA)Q86VP6
IntAct (EBI)Q86VP6
FunCoupENSG00000111530
BioGRIDCAND1
STRING (EMBL)CAND1
ZODIACCAND1
Ontologies - Pathways
QuickGOQ86VP6
Ontology : AmiGOubiquitin ligase complex  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  SCF complex assembly  membrane  protein ubiquitination  TBP-class protein binding  cell differentiation  cullin-RING ubiquitin ligase complex  secretory granule lumen  negative regulation of catalytic activity  neutrophil degranulation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIubiquitin ligase complex  protein binding  extracellular region  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  SCF complex assembly  membrane  protein ubiquitination  TBP-class protein binding  cell differentiation  cullin-RING ubiquitin ligase complex  secretory granule lumen  negative regulation of catalytic activity  neutrophil degranulation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  extracellular exosome  ficolin-1-rich granule lumen  
NDEx NetworkCAND1
Atlas of Cancer Signalling NetworkCAND1
Wikipedia pathwaysCAND1
Orthology - Evolution
OrthoDB55832
GeneTree (enSembl)ENSG00000111530
Phylogenetic Trees/Animal Genes : TreeFamCAND1
HOVERGENQ86VP6
HOGENOMQ86VP6
Homologs : HomoloGeneCAND1
Homology/Alignments : Family Browser (UCSC)CAND1
Gene fusions - Rearrangements
Fusion : MitelmanCAND1/EGFR [12q14.3/7p11.2]  
Fusion : MitelmanCAND1/TUSC5 [12q14.3/17p13.3]  [t(12;17)(q14;p13)]  
Fusion: TCGACAND1 12q14.3 TUSC5 17p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAND1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAND1
dbVarCAND1
ClinVarCAND1
1000_GenomesCAND1 
Exome Variant ServerCAND1
ExAC (Exome Aggregation Consortium)CAND1 (select the gene name)
Genetic variants : HAPMAP55832
Genomic Variants (DGV)CAND1 [DGVbeta]
DECIPHERCAND1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAND1 
Mutations
ICGC Data PortalCAND1 
TCGA Data PortalCAND1 
Broad Tumor PortalCAND1
OASIS PortalCAND1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAND1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAND1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAND1
DgiDB (Drug Gene Interaction Database)CAND1
DoCM (Curated mutations)CAND1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAND1 (select a term)
intoGenCAND1
Cancer3DCAND1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607727   
Orphanet
MedgenCAND1
Genetic Testing Registry CAND1
NextProtQ86VP6 [Medical]
TSGene55832
GENETestsCAND1
Huge Navigator CAND1 [HugePedia]
snp3D : Map Gene to Disease55832
BioCentury BCIQCAND1
ClinGenCAND1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55832
Chemical/Pharm GKB GenePA142672207
Clinical trialCAND1
Miscellaneous
canSAR (ICR)CAND1 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAND1
EVEXCAND1
GoPubMedCAND1
iHOPCAND1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:08:47 CEST 2017

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