CANT1 (calcium activated nucleotidase 1)

2011-08-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
DBQD,DBQD1,EDM7,SCAN-1,SCAN1,SHAPY
FUSION GENES

Other Information

Locus ID:

NCBI: 124583
MIM: 613165
HGNC: 19721
Ensembl: ENSG00000171302

Variants:

dbSNP: 124583
ClinVar: 124583
TCGA: ENSG00000171302
COSMIC: CANT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171302ENST00000302345Q8WVQ1
ENSG00000171302ENST00000302345A0A024R8U8
ENSG00000171302ENST00000392446Q8WVQ1
ENSG00000171302ENST00000392446A0A024R8U8
ENSG00000171302ENST00000586916K7EQT4
ENSG00000171302ENST00000588075K7EKT2
ENSG00000171302ENST00000588611K7EKW6
ENSG00000171302ENST00000590370K7EMT2
ENSG00000171302ENST00000591625K7EQD4
ENSG00000171302ENST00000591773Q8WVQ1
ENSG00000171302ENST00000591773A0A024R8U8
ENSG00000171302ENST00000591811K7EIP9
ENSG00000171302ENST00000592033K7EIP9
ENSG00000171302ENST00000592228K7EN15
ENSG00000171302ENST00000620915Q8WVQ1
ENSG00000171302ENST00000620915A0A024R8U8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184511332008Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer.31
122344962002Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases.21
198532392009Identification of CANT1 mutations in Desbuquois dysplasia.20
126002082003Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase.13
199489752009Integrative predictive model of coronary artery calcification in atherosclerosis.13
225393362012Further delineation of CANT1 phenotypic spectrum and demonstration of its role in proteoglycan synthesis.12
283306942017CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.11
210372752011CANT1 mutation is also responsible for Desbuquois dysplasia, type 2 and Kim variant.9
214354632011The androgen-regulated Calcium-Activated Nucleotidase 1 (CANT1) is commonly overexpressed in prostate cancer and is tumor-biologically relevant in vitro.7
182225312008Engineered human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo.4

Citation

Dessen P

CANT1 (calcium activated nucleotidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52312/cant1