Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CANX (calnexin)

Identity

Alias (NCBI)CNX
IP90
P90
HGNC (Hugo) CANX
HGNC Alias symbCNX
IP90
P90
HGNC Alias namemajor histocompatibility complex class I antigen-binding protein p88
LocusID (NCBI) 821
Atlas_Id 43915
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 179698967 and ends at 179731638 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALM1 (14q32.11) / CANX (5q35.3)CANX (5q35.3) / CANX (5q35.3)CANX (5q35.3) / EEF1A1 (6q13)
CANX (5q35.3) / IL1R2 (2q11.2)CANX (5q35.3) / KDM5B (1q32.1)CANX (5q35.3) / KIFC3 (16q21)
CANX (5q35.3) / MLIP (6p12.1)CANX (5q35.3) / PLPP3 (1p32.2)CANX (5q35.3) / PTMS (12p13.31)
CANX (5q35.3) / SNHG3 (1p35.3)CANX (5q35.3) / YBX3 (12p13.2)CLSPN (1p34.3) / CANX (5q35.3)
KIFC3 (16q21) / CANX (5q35.3)PRSS23 (11q14.2) / CANX (5q35.3)RBBP6 (16p12.1) / CANX (5q35.3)
TGFBR1 (9q22.33) / CANX (5q35.3)TMTC1 (12p11.22) / CANX (5q35.3)CANX 5q35.3 / IL1R2 2q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;5)(q11;q35) CANX/IL1R2

External links

Nomenclature
HGNC (Hugo)CANX   1473
Cards
Entrez_Gene (NCBI)CANX  821  calnexin
AliasesCNX; IP90; P90
GeneCards (Weizmann)CANX
Ensembl hg19 (Hinxton)ENSG00000127022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127022 [Gene_View]  ENSG00000127022 [Sequence]  chr5:179698967-179731638 [Contig_View]  CANX [Vega]
ICGC DataPortalENSG00000127022
TCGA cBioPortalCANX
AceView (NCBI)CANX
Genatlas (Paris)CANX
WikiGenes821
SOURCE (Princeton)CANX
Genetics Home Reference (NIH)CANX
Genomic and cartography
GoldenPath hg38 (UCSC)CANX  -     chr5:179698967-179731638 +  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CANX  -     5q35.3   [Description]    (hg19-Feb_2009)
GoldenPathCANX - 5q35.3 [CytoView hg19]  CANX - 5q35.3 [CytoView hg38]
ImmunoBaseENSG00000127022
genome Data Viewer NCBICANX [Mapview hg19]  
OMIM114217   
Gene and transcription
Genbank (Entrez)AF070646 AJ271880 AK129990 AK130080 AK294702
RefSeq transcript (Entrez)NM_001024649 NM_001363993 NM_001363994 NM_001363995 NM_001363996 NM_001363997 NM_001363998 NM_001363999 NM_001364000 NM_001364001 NM_001746
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CANX
Alternative Splicing GalleryENSG00000127022
Gene ExpressionCANX [ NCBI-GEO ]   CANX [ EBI - ARRAY_EXPRESS ]   CANX [ SEEK ]   CANX [ MEM ]
Gene Expression Viewer (FireBrowse)CANX [ Firebrowse - Broad ]
GenevisibleExpression of CANX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)821
GTEX Portal (Tissue expression)CANX
Human Protein AtlasENSG00000127022-CANX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27824   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27824  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27824
Splice isoforms : SwissVarP27824
PhosPhoSitePlusP27824
Domaine pattern : Prosite (Expaxy)CALRETICULIN_1 (PS00803)    CALRETICULIN_2 (PS00804)    CALRETICULIN_REPEAT (PS00805)   
Domains : Interpro (EBI)Calret/calnex    Calret/calnex_CS    Calreticulin/calnexin_P_dom_sf    ConA-like_dom_sf   
Domain families : Pfam (Sanger)Calreticulin (PF00262)   
Domain families : Pfam (NCBI)pfam00262   
Conserved Domain (NCBI)CANX
DMDM Disease mutations821
Blocks (Seattle)CANX
SuperfamilyP27824
Human Protein Atlas [tissue]ENSG00000127022-CANX [tissue]
Peptide AtlasP27824
HPRD00252
IPIIPI00941747   IPI00020984   IPI00965501   IPI00442866   IPI00477719   IPI00383227   IPI00967720   IPI00967621   IPI00964865   IPI00967451   IPI00965725   IPI00965485   IPI00966032   IPI00967973   IPI00964308   IPI00964943   IPI00964541   
Protein Interaction databases
DIP (DOE-UCLA)P27824
IntAct (EBI)P27824
FunCoupENSG00000127022
BioGRIDCANX
STRING (EMBL)CANX
ZODIACCANX
Ontologies - Pathways
QuickGOP27824
Ontology : AmiGOantigen processing and presentation of peptide antigen via MHC class I  RNA binding  calcium ion binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  endoplasmic reticulum membrane  smooth endoplasmic reticulum  rough endoplasmic reticulum  ribosome  protein folding  protein folding  aging  protein secretion  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  carbohydrate binding  axon  endoplasmic reticulum unfolded protein response  dendrite cytoplasm  protein-containing complex  apolipoprotein binding  protein folding in endoplasmic reticulum  ionotropic glutamate receptor binding  melanosome  neuronal cell body  dendritic spine  Mitochondria-associated ER Membrane  endoplasmic reticulum quality control compartment  synaptic vesicle endocytosis  unfolded protein binding  extracellular exosome  extracellular exosome  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  clathrin-dependent endocytosis  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic active zone membrane  
Ontology : EGO-EBIantigen processing and presentation of peptide antigen via MHC class I  RNA binding  calcium ion binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  endoplasmic reticulum membrane  smooth endoplasmic reticulum  rough endoplasmic reticulum  ribosome  protein folding  protein folding  aging  protein secretion  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  carbohydrate binding  axon  endoplasmic reticulum unfolded protein response  dendrite cytoplasm  protein-containing complex  apolipoprotein binding  protein folding in endoplasmic reticulum  ionotropic glutamate receptor binding  melanosome  neuronal cell body  dendritic spine  Mitochondria-associated ER Membrane  endoplasmic reticulum quality control compartment  synaptic vesicle endocytosis  unfolded protein binding  extracellular exosome  extracellular exosome  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  clathrin-dependent endocytosis  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic active zone membrane  
Pathways : KEGGProtein processing in endoplasmic reticulum    Phagosome    Antigen processing and presentation    Thyroid hormone synthesis    HTLV-I infection   
NDEx NetworkCANX
Atlas of Cancer Signalling NetworkCANX
Wikipedia pathwaysCANX
Orthology - Evolution
OrthoDB821
GeneTree (enSembl)ENSG00000127022
Phylogenetic Trees/Animal Genes : TreeFamCANX
HOGENOMP27824
Homologs : HomoloGeneCANX
Homology/Alignments : Family Browser (UCSC)CANX
Gene fusions - Rearrangements
Fusion : MitelmanCANX/IL1R2 [5q35.3/2q11.2]  
Fusion PortalCANX 5q35.3 IL1R2 2q11.2 HNSC
Fusion : QuiverCANX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCANX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CANX
dbVarCANX
ClinVarCANX
MonarchCANX
1000_GenomesCANX 
Exome Variant ServerCANX
GNOMAD BrowserENSG00000127022
Varsome BrowserCANX
Genetic variants : HAPMAP821
Genomic Variants (DGV)CANX [DGVbeta]
DECIPHERCANX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCANX 
Mutations
ICGC Data PortalCANX 
TCGA Data PortalCANX 
Broad Tumor PortalCANX
OASIS PortalCANX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCANX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCANX
Mutations and Diseases : HGMDCANX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CANX
DgiDB (Drug Gene Interaction Database)CANX
DoCM (Curated mutations)CANX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CANX (select a term)
intoGenCANX
Cancer3DCANX(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114217   
Orphanet
DisGeNETCANX
MedgenCANX
Genetic Testing Registry CANX
NextProtP27824 [Medical]
TSGene821
GENETestsCANX
Target ValidationCANX
Huge Navigator CANX [HugePedia]
snp3D : Map Gene to Disease821
BioCentury BCIQCANX
ClinGenCANX
Clinical trials, drugs, therapy
Protein Interactions : CTD821
Pharm GKB GenePA26055
Clinical trialCANX
Miscellaneous
canSAR (ICR)CANX (select the gene name)
HarmonizomeCANX
DataMed IndexCANX
Probes
Litterature
PubMed296 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCANX
EVEXCANX
GoPubMedCANX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:04:15 CEST 2020
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