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CAP1 (adenylate cyclase associated protein 1)

Identity

Alias_namesCAP
Alias_symbol (synonym)CAP
Other aliasCAP1-PEN
HGNC (Hugo) CAP1
LocusID (NCBI) 10487
Atlas_Id 50911
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 40040583 and ends at 40072649 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / CAP1 (1p34.2)ATP5O (21q22.11) / CAP1 (1p34.2)CAP1 (1p34.2) / BMP8B (1p34.2)
CAP1 (1p34.2) / CNTROB (17p13.1)CAP1 (1p34.2) / MACF1 (1p34.3)RACK1 (5q35.3) / CAP1 (1p34.2)
RLF (1p34.2) / CAP1 (1p34.2)UHMK1 (1q23.3) / CAP1 (1p34.2)ZMPSTE24 (1p34.2) / CAP1 (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CAP1   20040
Cards
Entrez_Gene (NCBI)CAP1  10487  adenylate cyclase associated protein 1
AliasesCAP; CAP1-PEN
GeneCards (Weizmann)CAP1
Ensembl hg19 (Hinxton)ENSG00000131236 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131236 [Gene_View]  chr1:40040583-40072649 [Contig_View]  CAP1 [Vega]
ICGC DataPortalENSG00000131236
TCGA cBioPortalCAP1
AceView (NCBI)CAP1
Genatlas (Paris)CAP1
WikiGenes10487
SOURCE (Princeton)CAP1
Genetics Home Reference (NIH)CAP1
Genomic and cartography
GoldenPath hg38 (UCSC)CAP1  -     chr1:40040583-40072649 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAP1  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblCAP1 - 1p34.2 [CytoView hg19]  CAP1 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBICAP1 [Mapview hg19]  CAP1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001105530 NM_001330502 NM_001350475 NM_001350476 NM_001350477 NM_001350478 NM_001350479 NM_001350480 NM_001350481 NM_001350482 NM_001350483 NM_001350484 NM_001350485 NM_006367
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAP1
Cluster EST : UnigeneHs.733189 [ NCBI ]
CGAP (NCI)Hs.733189
Alternative Splicing GalleryENSG00000131236
Gene ExpressionCAP1 [ NCBI-GEO ]   CAP1 [ EBI - ARRAY_EXPRESS ]   CAP1 [ SEEK ]   CAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10487
GTEX Portal (Tissue expression)CAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01518   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01518  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01518
Splice isoforms : SwissVarQ01518
PhosPhoSitePlusQ01518
Domaine pattern : Prosite (Expaxy)C_CAP_COFACTOR_C (PS51329)    CAP_1 (PS01088)    CAP_2 (PS01089)   
Domains : Interpro (EBI)Adenylate_cyclase-assoc_CAP    Adenylate_cyclase-assoc_CAP_C    Adenylate_cyclase-assoc_CAP_N    C-CAP_CF_C-like    CAP/MinC_C    CAP1    CAP_CS_C    CAP_CS_N    CARP_motif   
Domain families : Pfam (Sanger)CAP_C (PF08603)    CAP_N (PF01213)   
Domain families : Pfam (NCBI)pfam08603    pfam01213   
Domain families : Smart (EMBL)CARP (SM00673)  
Conserved Domain (NCBI)CAP1
DMDM Disease mutations10487
Blocks (Seattle)CAP1
PDB (SRS)1K8F   
PDB (PDBSum)1K8F   
PDB (IMB)1K8F   
PDB (RSDB)1K8F   
Structural Biology KnowledgeBase1K8F   
SCOP (Structural Classification of Proteins)1K8F   
CATH (Classification of proteins structures)1K8F   
SuperfamilyQ01518
Human Protein AtlasENSG00000131236
Peptide AtlasQ01518
HPRD09869
IPIIPI00008274   IPI00639931   IPI00939159   IPI01009563   IPI00642414   IPI00641881   IPI00514858   IPI00644589   IPI00644109   IPI00647351   IPI00646869   IPI00646269   IPI00645789   
Protein Interaction databases
DIP (DOE-UCLA)Q01518
IntAct (EBI)Q01518
FunCoupENSG00000131236
BioGRIDCAP1
STRING (EMBL)CAP1
ZODIACCAP1
Ontologies - Pathways
QuickGOQ01518
Ontology : AmiGOcell morphogenesis  ameboidal-type cell migration  actin binding  extracellular region  extracellular space  plasma membrane  focal adhesion  receptor-mediated endocytosis  establishment or maintenance of cell polarity  signal transduction  activation of adenylate cyclase activity  actin polymerization or depolymerization  adenylate cyclase binding  cortical actin cytoskeleton  azurophil granule lumen  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBIcell morphogenesis  ameboidal-type cell migration  actin binding  extracellular region  extracellular space  plasma membrane  focal adhesion  receptor-mediated endocytosis  establishment or maintenance of cell polarity  signal transduction  activation of adenylate cyclase activity  actin polymerization or depolymerization  adenylate cyclase binding  cortical actin cytoskeleton  azurophil granule lumen  neutrophil degranulation  extracellular exosome  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]   
NDEx NetworkCAP1
Atlas of Cancer Signalling NetworkCAP1
Wikipedia pathwaysCAP1
Orthology - Evolution
OrthoDB10487
GeneTree (enSembl)ENSG00000131236
Phylogenetic Trees/Animal Genes : TreeFamCAP1
HOVERGENQ01518
HOGENOMQ01518
Homologs : HomoloGeneCAP1
Homology/Alignments : Family Browser (UCSC)CAP1
Gene fusions - Rearrangements
Fusion : MitelmanCAP1/BMP8B [1p34.2/1p34.2]  
Fusion : MitelmanCAP1/MACF1 [1p34.2/1p34.3]  [t(1;1)(p34;p34)]  
Fusion Cancer (Beijing)AD_1 [CAP1]  -  1p34.2 [FUSC000931]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAP1
dbVarCAP1
ClinVarCAP1
1000_GenomesCAP1 
Exome Variant ServerCAP1
ExAC (Exome Aggregation Consortium)CAP1 (select the gene name)
Genetic variants : HAPMAP10487
Genomic Variants (DGV)CAP1 [DGVbeta]
DECIPHERCAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAP1 
Mutations
ICGC Data PortalCAP1 
TCGA Data PortalCAP1 
Broad Tumor PortalCAP1
OASIS PortalCAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAP1
DgiDB (Drug Gene Interaction Database)CAP1
DoCM (Curated mutations)CAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAP1 (select a term)
intoGenCAP1
Cancer3DCAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenCAP1
Genetic Testing Registry CAP1
NextProtQ01518 [Medical]
TSGene10487
GENETestsCAP1
Huge Navigator CAP1 [HugePedia]
snp3D : Map Gene to Disease10487
BioCentury BCIQCAP1
ClinGenCAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10487
Chemical/Pharm GKB GenePA399
Clinical trialCAP1
Miscellaneous
canSAR (ICR)CAP1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAP1
EVEXCAP1
GoPubMedCAP1
iHOPCAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:08:48 CEST 2017

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