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CAPG (capping protein (actin filament), gelsolin-like)

Written2009-11Peeyush Kumar Singh, Ranjan Tamuli
Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati-781 039, Assam, India

(Note : for Links provided by Atlas : click)


Other namesAFCP
LocusID (NCBI) 822
Atlas_Id 44449
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85621871 and ends at 85641197 bp from pter ( according to hg19-Feb_2009)  [Mapping CAPG.png]
Fusion genes
(updated 2016)
CAPG (2p11.2) / WDTC1 (1p36.11)ELN (7q11.23) / CAPG (2p11.2)PSAP (10q22.1) / CAPG (2p11.2)


Description DNA size: 15.58 kb; mRNA size: 1220 bp; 10 exons.


Description 348 amino acids; 38.518 kDa. CapG protein contains three gelsolin-like repeats in the position 27-75 (49), 148-188 (41), and 261-307 (47); and a nuclear localization signal (NES) 137-146 (10). Three natural variants, VAR-047776 (V41I), VAR-047777 (R198W), and VAR-047778 (R335H) have been reported.
Isoforms: Altogether 15 different isoforms (eight complete, one COOH complete, and six partial) have been predicted. Isoform jApr07 is annotated, contains 79 amino acids N-terminal to the first AUG.
Expression Ubiquitously expressed; highly expressed in prostate, lung, and kidney.
Localisation Cytoplasmic (52.2 %), cytoskeletal (21.7 %), and nuclear (13.0 %), according to PSORT II prediction.
Function CAPG encodes a member of the gelsolin/villin family of actin-regulatory proteins that reversibly blocks (capping) the barbed ends of F-actin filaments in a Ca 2+and phosphoinositide-regulated manner, but does not sever preformed actin filaments. Capping contributes to the control of actin-based motility in non-muscle cells. Dysregulation of actin-based motility is a prominent factor in cell transformation and is probably associated with carcinogenesis. CAPG is also involved in cell signaling, receptor-mediated membrane ruffling, and phagocytosis.
Homology The percent identity below represents identity of CAPG over an aligned region in UniGene.
- Pan troglodytes: 99.7 % (percentage identity)
- Macaca mulatta: 99.7 %
- Mus musculus: 95.4 %
- Rattus norvegicus: 92.8 %
- Bos taurus: 91.1 %
- Danio rerio: 61.7 %

Implicated in

Entity Breast cancer
Disease CAPG is expressed at higher levels in metastasizing breast cancer, than in normal breast epithelium. Furthermore, CapG protein is also transported more rapidly into the nucleus of the breast cancerous cells than the corresponding benign cells. CapG knockdown reduces invasiveness in Matrigel invasion assay, which supports the role of CAPG in cell motility. Thus, increased expression of CAPG leads to dysregulation of cell motility that promotes tumor invasion.
Entity Oral carcinogenesis
Note Significant overexpression of CapG protein was detected in oral squamous-cell carcinoma cells (OSCCs) and oral premalignant lesions (OPLs). Enhanced expression of CapG was also associated with large tumour size and advanced staging of OSCCs. Therefore, CapG may initiate or activate the neoplastic process of OSCC cells including the regulation of biologic behaviour of aggressive forms of cells rather than as a suppressor.
Entity Ovarian carcinomas
Disease In a Swedish women population, CAPG was expressed more in tumors among deceased patients than survivors with ovarian carcinomas. The stage III serous papillary adenocarcinomas of the ovary show higher CAPG expression and this is possibly correlated with the advance disease stage. Overexpression of CAPG promotes aggressive tumor progression.
Entity Pancreatic cancer
Note Up regulation and multiple isoforms of CapG were detected in pancreatic cancer tissue and cell lines. High level of CapG protein may possibly play an important role in pancreatic cancer cell motility and consequently dissemination.
Entity Ocular melanoma
Note CapG, which is a unique regulator of the actin cytoskeleton, is expressed in malignant melanomas of the uvea but not to a significant extent in normal uveal melanocytes.
Entity Tumorigenic progression in cell lines
Note Expression of the CapG protein was lost in the tumorigenic cell line, isolated from a human diploid fibroblast lineage. The CapG protein expression was lost also in cancer cell lines including stomach cancer, lung cancer and melanoma. The human stomach cancer cell line AZ 521 became non-tumorigenic after the introduction of CapG cDNA. Moreover, CapG expression was repressed in small-cell lung cancer tissues. These results indicate that CapG is a tumor suppressor gene involved in the tumorigenic progression of certain cancers.


Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
Dabiri GA, Young CL, Rosenbloom J, Southwick FS.
J Biol Chem. 1992 Aug 15;267(23):16545-52.
PMID 1322908
Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity.
Nomura H, Uzawa K, Ishigami T, Kouzu Y, Koike H, Ogawara K, Siiba M, Bukawa H, Yokoe H, Kubosawa H, Tanzawa H.
BMC Cancer. 2008 Feb 1;8:39.
PMID 18237446
Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas.
Partheen K, Levan K, Osterberg L, Claesson I, Fallenius G, Sundfeldt K, Horvath G.
Int J Cancer. 2008 Nov 1;123(9):2130-7.
PMID 18709641
Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress.
Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P.
J Biol Chem. 2003 Aug 1;278(31):29136-44. Epub 2003 May 17.
PMID 12754261
Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG.
Renz M, Betz B, Niederacher D, Bender HG, Langowski J.
Int J Cancer. 2008 Apr 1;122(7):1476-82.
PMID 18059028
Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility.
Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E.
Gut. 2007 Jan;56(1):95-106. Epub 2006 Jul 17.
PMID 16847067
The identification and differential expression of calcium-binding proteins associated with ocular melanoma.
Van Ginkel PR, Gee RL, Walker TM, Hu DN, Heizmann CW, Polans AS.
Biochim Biophys Acta. 1998 Dec 10;1448(2):290-7.
PMID 9920419
Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.
Watari A, Takaki K, Higashiyama S, Li Y, Satomi Y, Takao T, Tanemura A, Yamaguchi Y, Katayama I, Shimakage M, Miyashiro I, Takami K, Kodama K, Yutsudo M.
Oncogene. 2006 Nov 30;25(56):7373-80. Epub 2006 Jun 12.
PMID 16767159


This paper should be referenced as such :
Singh, PK ; Tamuli, R
CAPG (capping protein (actin filament), gelsolin-like)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(9):809-811.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)CAPG   1474
Entrez_Gene (NCBI)CAPG  822  capping actin protein, gelsolin like
AliasesAFCP; HEL-S-66; MCP
GeneCards (Weizmann)CAPG
Ensembl hg19 (Hinxton)ENSG00000042493 [Gene_View]  chr2:85621871-85641197 [Contig_View]  CAPG [Vega]
Ensembl hg38 (Hinxton)ENSG00000042493 [Gene_View]  chr2:85621871-85641197 [Contig_View]  CAPG [Vega]
ICGC DataPortalENSG00000042493
Genatlas (Paris)CAPG
SOURCE (Princeton)CAPG
Genetics Home Reference (NIH)CAPG
Genomic and cartography
GoldenPath hg19 (UCSC)CAPG  -     chr2:85621871-85641197 -  2p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CAPG  -     2p11.2   [Description]    (hg38-Dec_2013)
EnsemblCAPG - 2p11.2 [CytoView hg19]  CAPG - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBICAPG [Mapview hg19]  CAPG [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK130130 AK225374 AK225378 AK300507 AK309290
RefSeq transcript (Entrez)NM_001256139 NM_001256140 NM_001320732 NM_001320733 NM_001320734 NM_001747
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)CAPG
Cluster EST : UnigeneHs.516155 [ NCBI ]
CGAP (NCI)Hs.516155
Alternative Splicing GalleryENSG00000042493
Gene ExpressionCAPG [ NCBI-GEO ]   CAPG [ EBI - ARRAY_EXPRESS ]   CAPG [ SEEK ]   CAPG [ MEM ]
Gene Expression Viewer (FireBrowse)CAPG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)822
GTEX Portal (Tissue expression)CAPG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40121 (Uniprot)
NextProtP40121  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40121
Splice isoforms : SwissVarP40121 (Swissvar)
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom    CapG    Gelsolin-like_dom    Villin/Gelsolin   
Domain families : Pfam (Sanger)Gelsolin (PF00626)   
Domain families : Pfam (NCBI)pfam00626   
Domain families : Smart (EMBL)GEL (SM00262)  
DMDM Disease mutations822
Blocks (Seattle)CAPG
PDB (SRS)1J72    1JHW   
PDB (PDBSum)1J72    1JHW   
PDB (IMB)1J72    1JHW   
PDB (RSDB)1J72    1JHW   
Structural Biology KnowledgeBase1J72    1JHW   
SCOP (Structural Classification of Proteins)1J72    1JHW   
CATH (Classification of proteins structures)1J72    1JHW   
Human Protein AtlasENSG00000042493
Peptide AtlasP40121
IPIIPI00027341   IPI00908511   IPI00916783   IPI00972980   IPI00917562   IPI01011662   
Protein Interaction databases
IntAct (EBI)P40121
Ontologies - Pathways
Ontology : AmiGOactin binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  centriole  protein complex assembly  F-actin capping protein complex  protein domain specific binding  extracellular matrix disassembly  protein complex binding  melanosome  barbed-end actin filament capping  extracellular exosome  positive regulation of podosome assembly  mitotic spindle  Flemming body  
Ontology : EGO-EBIactin binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  centriole  protein complex assembly  F-actin capping protein complex  protein domain specific binding  extracellular matrix disassembly  protein complex binding  melanosome  barbed-end actin filament capping  extracellular exosome  positive regulation of podosome assembly  mitotic spindle  Flemming body  
NDEx NetworkCAPG
Atlas of Cancer Signalling NetworkCAPG
Wikipedia pathwaysCAPG
Orthology - Evolution
GeneTree (enSembl)ENSG00000042493
Phylogenetic Trees/Animal Genes : TreeFamCAPG
Homologs : HomoloGeneCAPG
Homology/Alignments : Family Browser (UCSC)CAPG
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAPG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAPG
Exome Variant ServerCAPG
ExAC (Exome Aggregation Consortium)CAPG (select the gene name)
Genetic variants : HAPMAP822
Genomic Variants (DGV)CAPG [DGVbeta]
DECIPHER (Syndromes)2:85621871-85641197  ENSG00000042493
CONAN: Copy Number AnalysisCAPG 
ICGC Data PortalCAPG 
TCGA Data PortalCAPG 
Broad Tumor PortalCAPG
OASIS PortalCAPG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAPG 
Mutations and Diseases : HGMDCAPG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAPG
DgiDB (Drug Gene Interaction Database)CAPG
DoCM (Curated mutations)CAPG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAPG (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry CAPG
NextProtP40121 [Medical]
Huge Navigator CAPG [HugePedia]
snp3D : Map Gene to Disease822
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD822
Chemical/Pharm GKB GenePA26056
Clinical trialCAPG
canSAR (ICR)CAPG (select the gene name)
Other databasePSORTII
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 10 11:33:32 CEST 2016

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