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CAPN11 (calpain 11)

Identity

Other aliascalpain11
HGNC (Hugo) CAPN11
LocusID (NCBI) 11131
Atlas_Id 61405
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44158811 and ends at 44184402 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAPN11   1478
Cards
Entrez_Gene (NCBI)CAPN11  11131  calpain 11
Aliasescalpain11
GeneCards (Weizmann)CAPN11
Ensembl hg19 (Hinxton)ENSG00000137225 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137225 [Gene_View]  ENSG00000137225 [Sequence]  chr6:44158811-44184402 [Contig_View]  CAPN11 [Vega]
ICGC DataPortalENSG00000137225
TCGA cBioPortalCAPN11
AceView (NCBI)CAPN11
Genatlas (Paris)CAPN11
WikiGenes11131
SOURCE (Princeton)CAPN11
Genetics Home Reference (NIH)CAPN11
Genomic and cartography
GoldenPath hg38 (UCSC)CAPN11  -     chr6:44158811-44184402 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAPN11  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblCAPN11 - 6p21.1 [CytoView hg19]  CAPN11 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBICAPN11 [Mapview hg19]  CAPN11 [Mapview hg38]
OMIM604822   
Gene and transcription
Genbank (Entrez)AJ242832 AK300107 AK309883 AK314054 BC033733
RefSeq transcript (Entrez)NM_007058
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAPN11
Cluster EST : UnigeneHs.225953 [ NCBI ]
CGAP (NCI)Hs.225953
Alternative Splicing GalleryENSG00000137225
Gene ExpressionCAPN11 [ NCBI-GEO ]   CAPN11 [ EBI - ARRAY_EXPRESS ]   CAPN11 [ SEEK ]   CAPN11 [ MEM ]
Gene Expression Viewer (FireBrowse)CAPN11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11131
GTEX Portal (Tissue expression)CAPN11
Human Protein AtlasENSG00000137225-CAPN11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMQ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMQ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMQ6
Splice isoforms : SwissVarQ9UMQ6
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   
PhosPhoSitePlusQ9UMQ6
Domaine pattern : Prosite (Expaxy)CALPAIN_CAT (PS50203)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    THIOL_PROTEASE_CYS (PS00139)   
Domains : Interpro (EBI)C2_III    Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Pept_cys_AS    Peptidase_C2_calpain_cat   
Domain families : Pfam (Sanger)Calpain_III (PF01067)    EF-hand_8 (PF13833)    Peptidase_C2 (PF00648)   
Domain families : Pfam (NCBI)pfam01067    pfam13833    pfam00648   
Domain families : Smart (EMBL)calpain_III (SM00720)  CysPc (SM00230)  EFh (SM00054)  
Conserved Domain (NCBI)CAPN11
DMDM Disease mutations11131
Blocks (Seattle)CAPN11
SuperfamilyQ9UMQ6
Human Protein Atlas [tissue]ENSG00000137225-CAPN11 [tissue]
Peptide AtlasQ9UMQ6
HPRD05315
IPIIPI00218934   IPI01010661   IPI00977046   IPI00984082   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMQ6
IntAct (EBI)Q9UMQ6
FunCoupENSG00000137225
BioGRIDCAPN11
STRING (EMBL)CAPN11
ZODIACCAPN11
Ontologies - Pathways
QuickGOQ9UMQ6
Ontology : AmiGOacrosomal vesicle  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  cytoplasm  proteolysis  peptidase activity  
Ontology : EGO-EBIacrosomal vesicle  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  cytoplasm  proteolysis  peptidase activity  
NDEx NetworkCAPN11
Atlas of Cancer Signalling NetworkCAPN11
Wikipedia pathwaysCAPN11
Orthology - Evolution
OrthoDB11131
GeneTree (enSembl)ENSG00000137225
Phylogenetic Trees/Animal Genes : TreeFamCAPN11
HOVERGENQ9UMQ6
HOGENOMQ9UMQ6
Homologs : HomoloGeneCAPN11
Homology/Alignments : Family Browser (UCSC)CAPN11
Gene fusions - Rearrangements
Fusion : QuiverCAPN11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAPN11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAPN11
dbVarCAPN11
ClinVarCAPN11
1000_GenomesCAPN11 
Exome Variant ServerCAPN11
ExAC (Exome Aggregation Consortium)ENSG00000137225
GNOMAD BrowserENSG00000137225
Varsome BrowserCAPN11
Genetic variants : HAPMAP11131
Genomic Variants (DGV)CAPN11 [DGVbeta]
DECIPHERCAPN11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAPN11 
Mutations
ICGC Data PortalCAPN11 
TCGA Data PortalCAPN11 
Broad Tumor PortalCAPN11
OASIS PortalCAPN11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAPN11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAPN11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAPN11
DgiDB (Drug Gene Interaction Database)CAPN11
DoCM (Curated mutations)CAPN11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAPN11 (select a term)
intoGenCAPN11
Cancer3DCAPN11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604822   
Orphanet
DisGeNETCAPN11
MedgenCAPN11
Genetic Testing Registry CAPN11
NextProtQ9UMQ6 [Medical]
TSGene11131
GENETestsCAPN11
Target ValidationCAPN11
Huge Navigator CAPN11 [HugePedia]
snp3D : Map Gene to Disease11131
BioCentury BCIQCAPN11
ClinGenCAPN11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11131
Chemical/Pharm GKB GenePA26059
Clinical trialCAPN11
Miscellaneous
canSAR (ICR)CAPN11 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAPN11
EVEXCAPN11
GoPubMedCAPN11
iHOPCAPN11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:39:11 CEST 2018

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