Identity
HGNC
LOCATION
Xq23
LOCUSID
ALIAS
CANPX,CAPNX,CalpM,DJ914P14.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 827
MIM: 300146
HGNC: 1483
Ensembl: ENSG00000077274
Variants:
dbSNP: 827
ClinVar: 827
TCGA: ENSG00000077274
COSMIC: CAPN6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000077274 | ENST00000324068 | Q9Y6Q1 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Degradation of the extracellular matrix | REACTOME | R-HSA-1474228 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37243758 | 2023 | Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6. | 0 |
| 37243758 | 2023 | Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6. | 0 |
| 36153320 | 2022 | A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases. | 1 |
| 36153320 | 2022 | A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases. | 1 |
| 32852077 | 2021 | The investigation of calpain in human placenta with fetal growth restriction. | 1 |
| 32852077 | 2021 | The investigation of calpain in human placenta with fetal growth restriction. | 1 |
| 32161009 | 2020 | CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway. | 4 |
| 32161009 | 2020 | CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway. | 4 |
| 31673071 | 2019 | Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion. | 5 |
| 31673071 | 2019 | Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion. | 5 |
| 26375440 | 2016 | miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1. | 30 |
| 27525442 | 2016 | Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. | 16 |
| 26375440 | 2016 | miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1. | 30 |
| 27525442 | 2016 | Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. | 16 |
| 21681744 | 2012 | Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. | 17 |
Citation
Dessen P
CAPN6 (calpain 6)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50536/capn6
