CAPNS1 (calpain small subunit 1)

2008-12-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
CALPAIN4,CANP,CANPS,CAPN4,CDPS,CSS1
FUSION GENES

Other Information

Locus ID:

NCBI: 826
MIM: 114170
HGNC: 1481
Ensembl: ENSG00000126247

Variants:

dbSNP: 826
ClinVar: 826
TCGA: ENSG00000126247
COSMIC: CAPNS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126247ENST00000246533P04632
ENSG00000126247ENST00000586851K7EIV0
ENSG00000126247ENST00000586963U3KQE2
ENSG00000126247ENST00000587718A0A0C4DGQ5
ENSG00000126247ENST00000588780K7ELJ7
ENSG00000126247ENST00000588815P04632
ENSG00000126247ENST00000589146K7EMQ1
ENSG00000126247ENST00000590049A0A075B7C0
ENSG00000126247ENST00000590211S4R3F9
ENSG00000126247ENST00000590874K7EKD8
ENSG00000126247ENST00000591041K7EM73
ENSG00000126247ENST00000592354U3KPR7
ENSG00000126247ENST00000592483K7ES78
ENSG00000126247ENST00000628018K7ELJ7
ENSG00000126247ENST00000628306K7EKD8
ENSG00000126247ENST00000629983K7EMQ1

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Developmental BiologyREACTOMER-HSA-1266738
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
242978662014Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype.28
121219832002Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.27
204198042010Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.18
156111362005AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading.17
288576682017MALAT1/miR-124/Capn4 axis regulates proliferation, invasion and EMT in nasopharyngeal carcinoma cells.17
233499412013Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.16
249629552014Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.15
253043842014The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.15
199426212010An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.14

Citation

Dessen P

CAPNS1 (calpain small subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50495/capns1