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CAPRIN1 (cell cycle associated protein 1)

Identity

Alias_namesM11S1
GPIAP1
membrane component, chromosome 11, surface marker 1
GPI-anchored membrane protein 1
Alias_symbol (synonym)caprin-1
RNG105
Other aliasGPIP137
GRIP137
p137GPI
HGNC (Hugo) CAPRIN1
LocusID (NCBI) 4076
Atlas_Id 52977
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 34051683 and ends at 34102610 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP32 (11q24.3) / CAPRIN1 (11p13)ASH1L (1q22) / CAPRIN1 (11p13)CAPRIN1 (11p13) / ARHGAP17 (16p12.1)
CAPRIN1 (11p13) / CAPRIN1 (11p13)CAPRIN1 (11p13) / COMMD9 (11p13)CAPRIN1 (11p13) / PDGFRB (5q32)
CAPRIN1 (11p13) / TRIM44 (11p13)CSTF3 (11p13) / CAPRIN1 (11p13)LOC100506233 () / CAPRIN1 (11p13)
NAT10 (11p13) / CAPRIN1 (11p13)TMEM14B (6p24.2) / CAPRIN1 (11p13)CAPRIN1 11p13 / COMMD9 11p13
CAPRIN1 11p13 / TRIM44 11p13NAT10 11p13 / CAPRIN1 11p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;11)(q33;p13) CAPRIN1/PDGFRB


External links

Nomenclature
HGNC (Hugo)CAPRIN1   6743
Cards
Entrez_Gene (NCBI)CAPRIN1  4076  cell cycle associated protein 1
AliasesGPIAP1; GPIP137; GRIP137; M11S1; 
RNG105; p137GPI
GeneCards (Weizmann)CAPRIN1
Ensembl hg19 (Hinxton)ENSG00000135387 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135387 [Gene_View]  chr11:34051683-34102610 [Contig_View]  CAPRIN1 [Vega]
ICGC DataPortalENSG00000135387
TCGA cBioPortalCAPRIN1
AceView (NCBI)CAPRIN1
Genatlas (Paris)CAPRIN1
WikiGenes4076
SOURCE (Princeton)CAPRIN1
Genetics Home Reference (NIH)CAPRIN1
Genomic and cartography
GoldenPath hg38 (UCSC)CAPRIN1  -     chr11:34051683-34102610 +  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAPRIN1  -     11p13   [Description]    (hg19-Feb_2009)
EnsemblCAPRIN1 - 11p13 [CytoView hg19]  CAPRIN1 - 11p13 [CytoView hg38]
Mapping of homologs : NCBICAPRIN1 [Mapview hg19]  CAPRIN1 [Mapview hg38]
OMIM601178   
Gene and transcription
Genbank (Entrez)AF086078 AK127972 AK299720 BC001731 BC015700
RefSeq transcript (Entrez)NM_005898 NM_203364
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAPRIN1
Cluster EST : UnigeneHs.471818 [ NCBI ]
CGAP (NCI)Hs.471818
Alternative Splicing GalleryENSG00000135387
Gene ExpressionCAPRIN1 [ NCBI-GEO ]   CAPRIN1 [ EBI - ARRAY_EXPRESS ]   CAPRIN1 [ SEEK ]   CAPRIN1 [ MEM ]
Gene Expression Viewer (FireBrowse)CAPRIN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4076
GTEX Portal (Tissue expression)CAPRIN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14444   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14444  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14444
Splice isoforms : SwissVarQ14444
PhosPhoSitePlusQ14444
Domains : Interpro (EBI)Caprin    Caprin-1_C   
Domain families : Pfam (Sanger)Caprin-1_C (PF12287)   
Domain families : Pfam (NCBI)pfam12287   
Conserved Domain (NCBI)CAPRIN1
DMDM Disease mutations4076
Blocks (Seattle)CAPRIN1
PDB (SRS)4WBE    4WBP   
PDB (PDBSum)4WBE    4WBP   
PDB (IMB)4WBE    4WBP   
PDB (RSDB)4WBE    4WBP   
Structural Biology KnowledgeBase4WBE    4WBP   
SCOP (Structural Classification of Proteins)4WBE    4WBP   
CATH (Classification of proteins structures)4WBE    4WBP   
SuperfamilyQ14444
Human Protein AtlasENSG00000135387
Peptide AtlasQ14444
HPRD03108
IPIIPI00783872   IPI00873926   IPI00910763   IPI00978969   IPI00982178   IPI00975644   
Protein Interaction databases
DIP (DOE-UCLA)Q14444
IntAct (EBI)Q14444
FunCoupENSG00000135387
BioGRIDCAPRIN1
STRING (EMBL)CAPRIN1
ZODIACCAPRIN1
Ontologies - Pathways
QuickGOQ14444
Ontology : AmiGOP-body  RNA binding  RNA binding  protein binding  cytosol  integral component of plasma membrane  cytoplasmic stress granule  membrane  negative regulation of translation  dendrite  positive regulation of dendrite morphogenesis  positive regulation of dendritic spine morphogenesis  
Ontology : EGO-EBIP-body  RNA binding  RNA binding  protein binding  cytosol  integral component of plasma membrane  cytoplasmic stress granule  membrane  negative regulation of translation  dendrite  positive regulation of dendrite morphogenesis  positive regulation of dendritic spine morphogenesis  
NDEx NetworkCAPRIN1
Atlas of Cancer Signalling NetworkCAPRIN1
Wikipedia pathwaysCAPRIN1
Orthology - Evolution
OrthoDB4076
GeneTree (enSembl)ENSG00000135387
Phylogenetic Trees/Animal Genes : TreeFamCAPRIN1
HOVERGENQ14444
HOGENOMQ14444
Homologs : HomoloGeneCAPRIN1
Homology/Alignments : Family Browser (UCSC)CAPRIN1
Gene fusions - Rearrangements
Fusion: TCGACAPRIN1 11p13 COMMD9 11p13 BRCA
Fusion: TCGACAPRIN1 11p13 TRIM44 11p13 LUAD
Fusion: TCGANAT10 11p13 CAPRIN1 11p13 BRCA OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAPRIN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAPRIN1
dbVarCAPRIN1
ClinVarCAPRIN1
1000_GenomesCAPRIN1 
Exome Variant ServerCAPRIN1
ExAC (Exome Aggregation Consortium)CAPRIN1 (select the gene name)
Genetic variants : HAPMAP4076
Genomic Variants (DGV)CAPRIN1 [DGVbeta]
DECIPHERCAPRIN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAPRIN1 
Mutations
ICGC Data PortalCAPRIN1 
TCGA Data PortalCAPRIN1 
Broad Tumor PortalCAPRIN1
OASIS PortalCAPRIN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAPRIN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAPRIN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAPRIN1
DgiDB (Drug Gene Interaction Database)CAPRIN1
DoCM (Curated mutations)CAPRIN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAPRIN1 (select a term)
intoGenCAPRIN1
Cancer3DCAPRIN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601178   
Orphanet
MedgenCAPRIN1
Genetic Testing Registry CAPRIN1
NextProtQ14444 [Medical]
TSGene4076
GENETestsCAPRIN1
Huge Navigator CAPRIN1 [HugePedia]
snp3D : Map Gene to Disease4076
BioCentury BCIQCAPRIN1
ClinGenCAPRIN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4076
Chemical/Pharm GKB GenePA30508
Clinical trialCAPRIN1
Miscellaneous
canSAR (ICR)CAPRIN1 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAPRIN1
EVEXCAPRIN1
GoPubMedCAPRIN1
iHOPCAPRIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:08:50 CEST 2017

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