Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CARD11 (caspase recruitment domain family member 11)

Identity

Alias_namescaspase recruitment domain family
Alias_symbol (synonym)CARMA1
BIMP3
Other aliasBENTA
IMD11
PPBL
HGNC (Hugo) CARD11
LocusID (NCBI) 84433
Atlas_Id 43188
Location 7p22.2  [Link to chromosome band 7p22]
Location_base_pair Starts at 2906076 and ends at 3043945 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		CARD11 (7p22.2) / ITGA11 (15q23)NOL11 (17q24.2) / CARD11 (7p22.2)NOL11 17q24.2 / CARD11 7p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)
t(14;18)(q32;q21) IGH/MALT1

External links

Nomenclature
HGNC (Hugo)CARD11   16393
LRG (Locus Reference Genomic)LRG_729
Cards
Entrez_Gene (NCBI)CARD11  84433  caspase recruitment domain family member 11
AliasesBENTA; BIMP3; CARMA1; IMD11; 
PPBL
GeneCards (Weizmann)CARD11
Ensembl hg19 (Hinxton)ENSG00000198286 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198286 [Gene_View]  chr7:2906076-3043945 [Contig_View]  CARD11 [Vega]
ICGC DataPortalENSG00000198286
TCGA cBioPortalCARD11
AceView (NCBI)CARD11
Genatlas (Paris)CARD11
WikiGenes84433
SOURCE (Princeton)CARD11
Genetics Home Reference (NIH)CARD11
Genomic and cartography
GoldenPath hg38 (UCSC)CARD11  -     chr7:2906076-3043945 -  7p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CARD11  -     7p22.2   [Description]    (hg19-Feb_2009)
EnsemblCARD11 - 7p22.2 [CytoView hg19]  CARD11 - 7p22.2 [CytoView hg38]
Mapping of homologs : NCBICARD11 [Mapview hg19]  CARD11 [Mapview hg38]
OMIM606445   607210   615206   616452   
Gene and transcription
Genbank (Entrez)AA194010 AA594170 AF322641 AF352576 AK074049
RefSeq transcript (Entrez)NM_001324281 NM_032415
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CARD11
Cluster EST : UnigeneHs.648101 [ NCBI ]
CGAP (NCI)Hs.648101
Alternative Splicing GalleryENSG00000198286
Gene ExpressionCARD11 [ NCBI-GEO ]   CARD11 [ EBI - ARRAY_EXPRESS ]   CARD11 [ SEEK ]   CARD11 [ MEM ]
Gene Expression Viewer (FireBrowse)CARD11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84433
GTEX Portal (Tissue expression)CARD11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXL7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXL7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXL7
Splice isoforms : SwissVarQ9BXL7
PhosPhoSitePlusQ9BXL7
Domaine pattern : Prosite (Expaxy)CARD (PS50209)   
Domains : Interpro (EBI)CARD    CARD11    DEATH-like_dom    P-loop_NTPase    PDZ   
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Conserved Domain (NCBI)CARD11
DMDM Disease mutations84433
Blocks (Seattle)CARD11
PDB (SRS)4JUP    4LWD   
PDB (PDBSum)4JUP    4LWD   
PDB (IMB)4JUP    4LWD   
PDB (RSDB)4JUP    4LWD   
Structural Biology KnowledgeBase4JUP    4LWD   
SCOP (Structural Classification of Proteins)4JUP    4LWD   
CATH (Classification of proteins structures)4JUP    4LWD   
SuperfamilyQ9BXL7
Human Protein AtlasENSG00000198286
Peptide AtlasQ9BXL7
HPRD06234
IPIIPI00869011   IPI00893535   IPI00885169   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXL7
IntAct (EBI)Q9BXL7
FunCoupENSG00000198286
BioGRIDCARD11
STRING (EMBL)CARD11
ZODIACCARD11
Ontologies - Pathways
QuickGOQ9BXL7
Ontology : AmiGOimmunological synapse  positive regulation of cytokine production  stimulatory C-type lectin receptor signaling pathway  immunoglobulin production  guanylate kinase activity  protein binding  cytoplasm  cytosol  plasma membrane  plasma membrane  B cell differentiation  positive regulation of B cell proliferation  T cell costimulation  Fc-epsilon receptor signaling pathway  B cell proliferation  T cell receptor complex  positive regulation of T cell proliferation  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  thymic T cell selection  positive regulation of interleukin-2 biosynthetic process  membrane raft  regulation of B cell differentiation  regulation of T cell differentiation  GMP metabolic process  GDP metabolic process  homeostasis of number of cells  CARD domain binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  interleukin-2 secretion  
Ontology : EGO-EBIimmunological synapse  positive regulation of cytokine production  stimulatory C-type lectin receptor signaling pathway  immunoglobulin production  guanylate kinase activity  protein binding  cytoplasm  cytosol  plasma membrane  plasma membrane  B cell differentiation  positive regulation of B cell proliferation  T cell costimulation  Fc-epsilon receptor signaling pathway  B cell proliferation  T cell receptor complex  positive regulation of T cell proliferation  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  thymic T cell selection  positive regulation of interleukin-2 biosynthetic process  membrane raft  regulation of B cell differentiation  regulation of T cell differentiation  GMP metabolic process  GDP metabolic process  homeostasis of number of cells  CARD domain binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  interleukin-2 secretion  
Pathways : KEGGNF-kappa B signaling pathway    T cell receptor signaling pathway    B cell receptor signaling pathway   
NDEx NetworkCARD11
Atlas of Cancer Signalling NetworkCARD11
Wikipedia pathwaysCARD11
Orthology - Evolution
OrthoDB84433
GeneTree (enSembl)ENSG00000198286
Phylogenetic Trees/Animal Genes : TreeFamCARD11
HOVERGENQ9BXL7
HOGENOMQ9BXL7
Homologs : HomoloGeneCARD11
Homology/Alignments : Family Browser (UCSC)CARD11
Gene fusions - Rearrangements
Fusion : MitelmanNOL11/CARD11 [17q24.2/7p22.2]  [t(7;17)(p22;q24)]  
Fusion: TCGANOL11 17q24.2 CARD11 7p22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCARD11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARD11
dbVarCARD11
ClinVarCARD11
1000_GenomesCARD11 
Exome Variant ServerCARD11
ExAC (Exome Aggregation Consortium)CARD11 (select the gene name)
Genetic variants : HAPMAP84433
Genomic Variants (DGV)CARD11 [DGVbeta]
DECIPHERCARD11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCARD11 
Mutations
ICGC Data PortalCARD11 
TCGA Data PortalCARD11 
Broad Tumor PortalCARD11
OASIS PortalCARD11 [ Somatic mutations - Copy number]
Cancer Gene: CensusCARD11 
Somatic Mutations in Cancer : COSMICCARD11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCARD11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CARD11
DgiDB (Drug Gene Interaction Database)CARD11
DoCM (Curated mutations)CARD11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CARD11 (select a term)
intoGenCARD11
Cancer3DCARD11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606445    607210    615206    616452   
Orphanet22219    21111   
MedgenCARD11
Genetic Testing Registry CARD11
NextProtQ9BXL7 [Medical]
TSGene84433
GENETestsCARD11
Target ValidationCARD11
Huge Navigator CARD11 [HugePedia]
snp3D : Map Gene to Disease84433
BioCentury BCIQCARD11
ClinGenCARD11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84433
Chemical/Pharm GKB GenePA26073
Clinical trialCARD11
Miscellaneous
canSAR (ICR)CARD11 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCARD11
EVEXCARD11
GoPubMedCARD11
iHOPCARD11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:48:42 CEST 2017
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