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CARD14 (caspase recruitment domain family, member 14)

Identity

Other namesBIMP2
CARMA2
PRP
PSORS2
PSS1
HGNC (Hugo) CARD14
LocusID (NCBI) 79092
Location 17q25.3
Location_base_pair Starts at 78152307 and ends at 78176430 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CARD14   16446
Cards
Entrez_Gene (NCBI)CARD14  79092  caspase recruitment domain family, member 14
GeneCards (Weizmann)CARD14
Ensembl hg19 (Hinxton)ENSG00000141527 [Gene_View]  chr17:78152307-78176430 [Contig_View]  CARD14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141527 [Gene_View]  chr17:78152307-78176430 [Contig_View]  CARD14 [Vega]
ICGC DataPortalENSG00000141527
cBioPortalCARD14
AceView (NCBI)CARD14
Genatlas (Paris)CARD14
WikiGenes79092
SOURCE (Princeton)CARD14
Genomic and cartography
GoldenPath hg19 (UCSC)CARD14  -     chr17:78152307-78176430 +  17q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CARD14  -     17q25.3   [Description]    (hg38-Dec_2013)
EnsemblCARD14 - 17q25.3 [CytoView hg19]  CARD14 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBICARD14 [Mapview hg19]  CARD14 [Mapview hg38]
OMIM173200   602723   607211   
Gene and transcription
Genbank (Entrez)AF322642 AK002138 AK054723 AK091123 AK095416
RefSeq transcript (Entrez)NM_001257970 NM_024110 NM_052819
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_032778 NT_010783 NW_001838457 NW_004929407
Consensus coding sequences : CCDS (NCBI)CARD14
Cluster EST : UnigeneHs.735899 [ NCBI ]
CGAP (NCI)Hs.735899
Alternative Splicing : Fast-db (Paris)GSHG0012882
Alternative Splicing GalleryENSG00000141527
Gene ExpressionCARD14 [ NCBI-GEO ]     CARD14 [ SEEK ]   CARD14 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXL6 (Uniprot)
NextProtQ9BXL6  [Medical]
With graphics : InterProQ9BXL6
Splice isoforms : SwissVarQ9BXL6 (Swissvar)
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)   
Domains : Interpro (EBI)CARD    DEATH-like_dom    GK/Ca_channel_bsu    Guanylate_kin-like    P-loop_NTPase    PDZ   
Related proteins : CluSTrQ9BXL6
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  
DMDM Disease mutations79092
Blocks (Seattle)Q9BXL6
Human Protein AtlasENSG00000141527
Peptide AtlasQ9BXL6
HPRD06235
IPIIPI00012213   IPI00910534   IPI00031392   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXL6
IntAct (EBI)Q9BXL6
FunCoupENSG00000141527
BioGRIDCARD14
IntegromeDBCARD14
STRING (EMBL)CARD14
Ontologies - Pathways
QuickGOQ9BXL6
Ontology : AmiGOpositive regulation of protein phosphorylation  cytoplasm  plasma membrane  apoptotic process  activation of NF-kappaB-inducing kinase activity  tumor necrosis factor-mediated signaling pathway  negative regulation of apoptotic process  CARD domain binding  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  cytoplasm  plasma membrane  apoptotic process  activation of NF-kappaB-inducing kinase activity  tumor necrosis factor-mediated signaling pathway  negative regulation of apoptotic process  CARD domain binding  positive regulation of NF-kappaB transcription factor activity  
Protein Interaction DatabaseCARD14
DoCM (Curated mutations)CARD14
Wikipedia pathwaysCARD14
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCARD14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARD14
dbVarCARD14
ClinVarCARD14
1000_GenomesCARD14 
Exome Variant ServerCARD14
SNP (GeneSNP Utah)CARD14
SNP : HGBaseCARD14
Genetic variants : HAPMAPCARD14
Genomic VariantsCARD14  CARD14 [DGVbeta]
Mutations
ICGC Data PortalENSG00000141527 
Somatic Mutations in Cancer : COSMICCARD14 
CONAN: Copy Number AnalysisCARD14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:78152307-78176430
Mutations and Diseases : HGMDCARD14
OMIM173200    602723    607211   
MedgenCARD14
NextProtQ9BXL6 [Medical]
GENETestsCARD14
Disease Genetic AssociationCARD14
Huge Navigator CARD14 [HugePedia]  CARD14 [HugeCancerGEM]
snp3D : Map Gene to Disease79092
DGIdb (Drug Gene Interaction db)CARD14
General knowledge
Homologs : HomoloGeneCARD14
Homology/Alignments : Family Browser (UCSC)CARD14
Phylogenetic Trees/Animal Genes : TreeFamCARD14
Chemical/Protein Interactions : CTD79092
Chemical/Pharm GKB GenePA134959119
Clinical trialCARD14
Cancer Resource (Charite)ENSG00000141527
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
CoreMineCARD14
GoPubMedCARD14
iHOPCARD14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:37:06 CET 2014

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