Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CARD16 (caspase recruitment domain family member 16)

Identity

Alias_namescaspase recruitment domain family
Alias_symbol (synonym)COP1
COP
PSEUDO-ICE
Other alias
HGNC (Hugo) CARD16
LocusID (NCBI) 114769
Atlas_Id 43217
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 105041326 and ends at 105045324 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CARD16   33701
Cards
Entrez_Gene (NCBI)CARD16  114769  caspase recruitment domain family member 16
AliasesCOP; COP1; PSEUDO-ICE
GeneCards (Weizmann)CARD16
Ensembl hg19 (Hinxton)ENSG00000204397 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204397 [Gene_View]  ENSG00000204397 [Sequence]  chr11:105041326-105045324 [Contig_View]  CARD16 [Vega]
ICGC DataPortalENSG00000204397
TCGA cBioPortalCARD16
AceView (NCBI)CARD16
Genatlas (Paris)CARD16
WikiGenes114769
SOURCE (Princeton)CARD16
Genetics Home Reference (NIH)CARD16
Genomic and cartography
GoldenPath hg38 (UCSC)CARD16  -     chr11:105041326-105045324 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CARD16  -     11q22.3   [Description]    (hg19-Feb_2009)
EnsemblCARD16 - 11q22.3 [CytoView hg19]  CARD16 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICARD16 [Mapview hg19]  CARD16 [Mapview hg38]
OMIM615680   
Gene and transcription
Genbank (Entrez)AF367017 AK125640 AK311902 AY885669 BC033638
RefSeq transcript (Entrez)NM_001017534 NM_052889
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CARD16
Cluster EST : UnigeneHs.348365 [ NCBI ]
CGAP (NCI)Hs.348365
Alternative Splicing GalleryENSG00000204397
Gene ExpressionCARD16 [ NCBI-GEO ]   CARD16 [ EBI - ARRAY_EXPRESS ]   CARD16 [ SEEK ]   CARD16 [ MEM ]
Gene Expression Viewer (FireBrowse)CARD16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114769
GTEX Portal (Tissue expression)CARD16
Human Protein AtlasENSG00000204397-CARD16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5EG05   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5EG05  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5EG05
Splice isoforms : SwissVarQ5EG05
PhosPhoSitePlusQ5EG05
Domaine pattern : Prosite (Expaxy)CARD (PS50209)   
Domains : Interpro (EBI)CARD    DEATH-like_dom_sf   
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Domain families : Smart (EMBL)CARD (SM00114)  
Conserved Domain (NCBI)CARD16
DMDM Disease mutations114769
Blocks (Seattle)CARD16
SuperfamilyQ5EG05
Human Protein Atlas [tissue]ENSG00000204397-CARD16 [tissue]
Peptide AtlasQ5EG05
HPRD16740
IPIIPI00554741   IPI00066313   IPI00979697   
Protein Interaction databases
DIP (DOE-UCLA)Q5EG05
IntAct (EBI)Q5EG05
FunCoupENSG00000204397
BioGRIDCARD16
STRING (EMBL)CARD16
ZODIACCARD16
Ontologies - Pathways
QuickGOQ5EG05
Ontology : AmiGOcysteine-type endopeptidase activity  cysteine-type endopeptidase inhibitor activity  protein binding  proteolysis  negative regulation of tumor necrosis factor-mediated signaling pathway  kinase binding  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of protein binding  protein-containing complex  protein-containing complex  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  CARD domain binding  negative regulation of interleukin-1 beta secretion  negative regulation of interleukin-1 beta secretion  positive regulation of NF-kappaB transcription factor activity  cellular response to lipopolysaccharide  cellular response to hypoxia  cellular response to UV-C  caspase binding  caspase binding  protease inhibitor complex  inhibition of cysteine-type endopeptidase activity  
Ontology : EGO-EBIcysteine-type endopeptidase activity  cysteine-type endopeptidase inhibitor activity  protein binding  proteolysis  negative regulation of tumor necrosis factor-mediated signaling pathway  kinase binding  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of protein binding  protein-containing complex  protein-containing complex  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  CARD domain binding  negative regulation of interleukin-1 beta secretion  negative regulation of interleukin-1 beta secretion  positive regulation of NF-kappaB transcription factor activity  cellular response to lipopolysaccharide  cellular response to hypoxia  cellular response to UV-C  caspase binding  caspase binding  protease inhibitor complex  inhibition of cysteine-type endopeptidase activity  
NDEx NetworkCARD16
Atlas of Cancer Signalling NetworkCARD16
Wikipedia pathwaysCARD16
Orthology - Evolution
OrthoDB114769
GeneTree (enSembl)ENSG00000204397
Phylogenetic Trees/Animal Genes : TreeFamCARD16
HOGENOMQ5EG05
Homologs : HomoloGeneCARD16
Homology/Alignments : Family Browser (UCSC)CARD16
Gene fusions - Rearrangements
Fusion : QuiverCARD16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCARD16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARD16
dbVarCARD16
ClinVarCARD16
1000_GenomesCARD16 
Exome Variant ServerCARD16
ExAC (Exome Aggregation Consortium)ENSG00000204397
GNOMAD BrowserENSG00000204397
Varsome BrowserCARD16
Genetic variants : HAPMAP114769
Genomic Variants (DGV)CARD16 [DGVbeta]
DECIPHERCARD16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCARD16 
Mutations
ICGC Data PortalCARD16 
TCGA Data PortalCARD16 
Broad Tumor PortalCARD16
OASIS PortalCARD16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCARD16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCARD16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CARD16
DgiDB (Drug Gene Interaction Database)CARD16
DoCM (Curated mutations)CARD16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CARD16 (select a term)
intoGenCARD16
Cancer3DCARD16(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615680   
Orphanet
DisGeNETCARD16
MedgenCARD16
Genetic Testing Registry CARD16
NextProtQ5EG05 [Medical]
TSGene114769
GENETestsCARD16
Target ValidationCARD16
Huge Navigator CARD16 [HugePedia]
snp3D : Map Gene to Disease114769
BioCentury BCIQCARD16
ClinGenCARD16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114769
Chemical/Pharm GKB GenePA164717628
Clinical trialCARD16
Miscellaneous
canSAR (ICR)CARD16 (select the gene name)
DataMed IndexCARD16
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCARD16
EVEXCARD16
GoPubMedCARD16
iHOPCARD16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:04:26 CET 2019
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