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CARM1 (coactivator associated arginine methyltransferase 1)

Identity

Alias_symbol (synonym)PRMT4
Other alias
HGNC (Hugo) CARM1
LocusID (NCBI) 10498
Atlas_Id 43874
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10871577 and ends at 10922772 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CARM1 (19p13.2) / C19orf38 (19p13.2)CARM1 (19p13.2) / DNM2 (19p13.2)CARM1 (19p13.2) / MED26 (19p13.11)
CARM1 (19p13.2) / MIR548N (2q31.2)CARM1 (19p13.2) / OLFM2 (19p13.2)GSK3B (3q13.33) / CARM1 (19p13.2)
LAMA3 (18q11.2) / CARM1 (19p13.2)SMARCA4 (19p13.2) / CARM1 (19p13.2)CARM1 19p13.2 / C19orf38 19p13.2
CARM1 19p13.2 / OLFM2 19p13.2SMARCA4 19p13.2 / CARM1 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CARM1   23393
Cards
Entrez_Gene (NCBI)CARM1  10498  coactivator associated arginine methyltransferase 1
AliasesPRMT4
GeneCards (Weizmann)CARM1
Ensembl hg19 (Hinxton)ENSG00000142453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142453 [Gene_View]  chr19:10871577-10922772 [Contig_View]  CARM1 [Vega]
ICGC DataPortalENSG00000142453
TCGA cBioPortalCARM1
AceView (NCBI)CARM1
Genatlas (Paris)CARM1
WikiGenes10498
SOURCE (Princeton)CARM1
Genetics Home Reference (NIH)CARM1
Genomic and cartography
GoldenPath hg38 (UCSC)CARM1  -     chr19:10871577-10922772 +  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CARM1  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblCARM1 - 19p13.2 [CytoView hg19]  CARM1 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBICARM1 [Mapview hg19]  CARM1 [Mapview hg38]
OMIM603934   
Gene and transcription
Genbank (Entrez)AF055027 AL833242 BC036886 BC046240 BC070496
RefSeq transcript (Entrez)NM_199141
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CARM1
Cluster EST : UnigeneHs.323213 [ NCBI ]
CGAP (NCI)Hs.323213
Alternative Splicing GalleryENSG00000142453
Gene ExpressionCARM1 [ NCBI-GEO ]   CARM1 [ EBI - ARRAY_EXPRESS ]   CARM1 [ SEEK ]   CARM1 [ MEM ]
Gene Expression Viewer (FireBrowse)CARM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10498
GTEX Portal (Tissue expression)CARM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86X55   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86X55  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86X55
Splice isoforms : SwissVarQ86X55
PhosPhoSitePlusQ86X55
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)   
Domains : Interpro (EBI)Arg_MeTrfase    Histone-Arg_MeTrfase_N    SAM-dependent_MTases   
Domain families : Pfam (Sanger)CARM1 (PF11531)    PRMT5 (PF05185)   
Domain families : Pfam (NCBI)pfam11531    pfam05185   
Conserved Domain (NCBI)CARM1
DMDM Disease mutations10498
Blocks (Seattle)CARM1
PDB (SRS)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
PDB (PDBSum)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
PDB (IMB)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
PDB (RSDB)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
Structural Biology KnowledgeBase2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
SCOP (Structural Classification of Proteins)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
CATH (Classification of proteins structures)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X   
SuperfamilyQ86X55
Human Protein AtlasENSG00000142453
Peptide AtlasQ86X55
HPRD09158
IPIIPI00412880   IPI00514607   IPI00639957   
Protein Interaction databases
DIP (DOE-UCLA)Q86X55
IntAct (EBI)Q86X55
FunCoupENSG00000142453
BioGRIDCARM1
STRING (EMBL)CARM1
ZODIACCARM1
Ontologies - Pathways
QuickGOQ86X55
Ontology : AmiGORNA polymerase II transcription coactivator activity  regulation of growth plate cartilage chondrocyte proliferation  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  aging  beta-catenin binding  protein methyltransferase activity  positive regulation of cell proliferation  histone-arginine N-methyltransferase activity  viral process  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  negative regulation of protein binding  regulation of intracellular estrogen receptor signaling pathway  histone H3-R2 methylation  histone H3-R17 methylation  protein-arginine omega-N asymmetric methyltransferase activity  histone methyltransferase activity (H3-R17 specific)  histone methyltransferase activity  protein homodimerization activity  transcription regulatory region DNA binding  cellular lipid metabolic process  positive regulation of fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of NF-kappaB transcription factor activity  response to cAMP  endochondral bone morphogenesis  lysine-acetylated histone binding  protein localization to chromatin  RNA polymerase II transcription factor complex  regulation of mRNA binding  negative regulation of dendrite development  
Ontology : EGO-EBIRNA polymerase II transcription coactivator activity  regulation of growth plate cartilage chondrocyte proliferation  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  aging  beta-catenin binding  protein methyltransferase activity  positive regulation of cell proliferation  histone-arginine N-methyltransferase activity  viral process  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  negative regulation of protein binding  regulation of intracellular estrogen receptor signaling pathway  histone H3-R2 methylation  histone H3-R17 methylation  protein-arginine omega-N asymmetric methyltransferase activity  histone methyltransferase activity (H3-R17 specific)  histone methyltransferase activity  protein homodimerization activity  transcription regulatory region DNA binding  cellular lipid metabolic process  positive regulation of fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of NF-kappaB transcription factor activity  response to cAMP  endochondral bone morphogenesis  lysine-acetylated histone binding  protein localization to chromatin  RNA polymerase II transcription factor complex  regulation of mRNA binding  negative regulation of dendrite development  
Pathways : BIOCARTATranscription Regulation by Methyltransferase of CARM1 [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]    CARM1 and Regulation of the Estrogen Receptor [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
NDEx NetworkCARM1
Atlas of Cancer Signalling NetworkCARM1
Wikipedia pathwaysCARM1
Orthology - Evolution
OrthoDB10498
GeneTree (enSembl)ENSG00000142453
Phylogenetic Trees/Animal Genes : TreeFamCARM1
HOVERGENQ86X55
HOGENOMQ86X55
Homologs : HomoloGeneCARM1
Homology/Alignments : Family Browser (UCSC)CARM1
Gene fusions - Rearrangements
Fusion : MitelmanCARM1/C19orf38 [19p13.2/19p13.2]  
Fusion : MitelmanCARM1/OLFM2 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanSMARCA4/CARM1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion: TCGACARM1 19p13.2 C19orf38 19p13.2 LUSC OV
Fusion: TCGACARM1 19p13.2 OLFM2 19p13.2 LUSC
Fusion: TCGASMARCA4 19p13.2 CARM1 19p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCARM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARM1
dbVarCARM1
ClinVarCARM1
1000_GenomesCARM1 
Exome Variant ServerCARM1
ExAC (Exome Aggregation Consortium)CARM1 (select the gene name)
Genetic variants : HAPMAP10498
Genomic Variants (DGV)CARM1 [DGVbeta]
DECIPHERCARM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCARM1 
Mutations
ICGC Data PortalCARM1 
TCGA Data PortalCARM1 
Broad Tumor PortalCARM1
OASIS PortalCARM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCARM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCARM1
intOGen PortalCARM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CARM1
DgiDB (Drug Gene Interaction Database)CARM1
DoCM (Curated mutations)CARM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CARM1 (select a term)
intoGenCARM1
Cancer3DCARM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603934   
Orphanet
MedgenCARM1
Genetic Testing Registry CARM1
NextProtQ86X55 [Medical]
TSGene10498
GENETestsCARM1
Target ValidationCARM1
Huge Navigator CARM1 [HugePedia]
snp3D : Map Gene to Disease10498
BioCentury BCIQCARM1
ClinGenCARM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10498
Chemical/Pharm GKB GenePA134959553
Clinical trialCARM1
Miscellaneous
canSAR (ICR)CARM1 (select the gene name)
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCARM1
EVEXCARM1
GoPubMedCARM1
iHOPCARM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:26:42 CEST 2017

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