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CARM1 (coactivator associated arginine methyltransferase 1)

Identity

Alias (NCBI)PRMT4
HGNC (Hugo) CARM1
HGNC Alias symbPRMT4
LocusID (NCBI) 10498
Atlas_Id 43874
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10871553 and ends at 10923073 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CARM1 (19p13.2) / C19orf38 (19p13.2)CARM1 (19p13.2) / DNM2 (19p13.2)CARM1 (19p13.2) / MED26 (19p13.11)
CARM1 (19p13.2) / MIR548N (2q31.2)CARM1 (19p13.2) / OLFM2 (19p13.2)GSK3B (3q13.33) / CARM1 (19p13.2)
LAMA3 (18q11.2) / CARM1 (19p13.2)SMARCA4 (19p13.2) / CARM1 (19p13.2)CARM1 19p13.2 / C19orf38 19p13.2
CARM1 19p13.2 / OLFM2 19p13.2SMARCA4 19p13.2 / CARM1 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CARM1   23393
Cards
Entrez_Gene (NCBI)CARM1    coactivator associated arginine methyltransferase 1
AliasesPRMT4
GeneCards (Weizmann)CARM1
Ensembl hg19 (Hinxton)ENSG00000142453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142453 [Gene_View]  ENSG00000142453 [Sequence]  chr19:10871553-10923073 [Contig_View]  CARM1 [Vega]
ICGC DataPortalENSG00000142453
TCGA cBioPortalCARM1
AceView (NCBI)CARM1
Genatlas (Paris)CARM1
SOURCE (Princeton)CARM1
Genetics Home Reference (NIH)CARM1
Genomic and cartography
GoldenPath hg38 (UCSC)CARM1  -     chr19:10871553-10923073 +  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CARM1  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathCARM1 - 19p13.2 [CytoView hg19]  CARM1 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000142453
Genome Data Viewer NCBICARM1 [Mapview hg19]  
OMIM603934   
Gene and transcription
Genbank (Entrez)AF055027 AL833242 BC036886 BC046240 BC070496
RefSeq transcript (Entrez)NM_001370088 NM_001370089 NM_199141
Consensus coding sequences : CCDS (NCBI)CARM1
Gene ExpressionCARM1 [ NCBI-GEO ]   CARM1 [ EBI - ARRAY_EXPRESS ]   CARM1 [ SEEK ]   CARM1 [ MEM ]
Gene Expression Viewer (FireBrowse)CARM1 [ Firebrowse - Broad ]
GenevisibleExpression of CARM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10498
GTEX Portal (Tissue expression)CARM1
Human Protein AtlasENSG00000142453-CARM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86X55   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86X55  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86X55
PhosPhoSitePlusQ86X55
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)   
Domains : Interpro (EBI)Arg_MeTrfase    Histone-Arg_MeTrfase_N    PH-like_dom_sf    SAM-dependent_MTases   
Domain families : Pfam (Sanger)CARM1 (PF11531)   
Domain families : Pfam (NCBI)pfam11531   
Conserved Domain (NCBI)CARM1
PDB (RSDB)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
PDB Europe2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
PDB (PDBSum)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
PDB (IMB)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
Structural Biology KnowledgeBase2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
SCOP (Structural Classification of Proteins)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
CATH (Classification of proteins structures)2Y1W    2Y1X    4IKP    5DWQ    5DX0    5DX1    5DX8    5DXA    5DXJ    5U4X    6ARJ    6ARV    6D2L    6DVR    6IZQ    6S70    6S71    6S74    6S77    6S79    6S7A    6S7B    6S7C   
SuperfamilyQ86X55
AlphaFold pdb e-kbQ86X55   
Human Protein Atlas [tissue]ENSG00000142453-CARM1 [tissue]
HPRD09158
Protein Interaction databases
DIP (DOE-UCLA)Q86X55
IntAct (EBI)Q86X55
BioGRIDCARM1
STRING (EMBL)CARM1
ZODIACCARM1
Ontologies - Pathways
QuickGOQ86X55
Ontology : AmiGOtranscription cis-regulatory region binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  aging  beta-catenin binding  protein methyltransferase activity  positive regulation of cell population proliferation  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  regulation of lipid metabolic process  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  nuclear receptor coactivator activity  regulation of intracellular estrogen receptor signaling pathway  histone H3-R2 methylation  histone H3-R17 methylation  protein-arginine omega-N asymmetric methyltransferase activity  histone methyltransferase activity (H3-R17 specific)  histone methyltransferase activity  positive regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  response to cAMP  lysine-acetylated histone binding  regulation of mRNA binding  negative regulation of dendrite development  
Ontology : EGO-EBItranscription cis-regulatory region binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  aging  beta-catenin binding  protein methyltransferase activity  positive regulation of cell population proliferation  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  regulation of lipid metabolic process  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  nuclear receptor coactivator activity  regulation of intracellular estrogen receptor signaling pathway  histone H3-R2 methylation  histone H3-R17 methylation  protein-arginine omega-N asymmetric methyltransferase activity  histone methyltransferase activity (H3-R17 specific)  histone methyltransferase activity  positive regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  response to cAMP  lysine-acetylated histone binding  regulation of mRNA binding  negative regulation of dendrite development  
Pathways : BIOCARTATranscription Regulation by Methyltransferase of CARM1 [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]    CARM1 and Regulation of the Estrogen Receptor [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
NDEx NetworkCARM1
Atlas of Cancer Signalling NetworkCARM1
Wikipedia pathwaysCARM1
Orthology - Evolution
OrthoDB10498
GeneTree (enSembl)ENSG00000142453
Phylogenetic Trees/Animal Genes : TreeFamCARM1
Homologs : HomoloGeneCARM1
Homology/Alignments : Family Browser (UCSC)CARM1
Gene fusions - Rearrangements
Fusion : MitelmanCARM1/C19orf38 [19p13.2/19p13.2]  
Fusion : MitelmanCARM1/OLFM2 [19p13.2/19p13.2]  
Fusion : MitelmanSMARCA4/CARM1 [19p13.2/19p13.2]  
Fusion : QuiverCARM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCARM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARM1
dbVarCARM1
ClinVarCARM1
MonarchCARM1
1000_GenomesCARM1 
Exome Variant ServerCARM1
GNOMAD BrowserENSG00000142453
Varsome BrowserCARM1
ACMGCARM1 variants
VarityQ86X55
Genomic Variants (DGV)CARM1 [DGVbeta]
DECIPHERCARM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCARM1 
Mutations
ICGC Data PortalCARM1 
TCGA Data PortalCARM1 
Broad Tumor PortalCARM1
OASIS PortalCARM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCARM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCARM1
Mutations and Diseases : HGMDCARM1
intOGen PortalCARM1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCARM1
DgiDB (Drug Gene Interaction Database)CARM1
DoCM (Curated mutations)CARM1
CIViC (Clinical Interpretations of Variants in Cancer)CARM1
Cancer3DCARM1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603934   
Orphanet
DisGeNETCARM1
MedgenCARM1
Genetic Testing Registry CARM1
NextProtQ86X55 [Medical]
GENETestsCARM1
Target ValidationCARM1
Huge Navigator CARM1 [HugePedia]
ClinGenCARM1
Clinical trials, drugs, therapy
MyCancerGenomeCARM1
Protein Interactions : CTDCARM1
Pharm GKB GenePA134959553
PharosQ86X55
Clinical trialCARM1
Miscellaneous
canSAR (ICR)CARM1
HarmonizomeCARM1
DataMed IndexCARM1
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCARM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:15 CEST 2021

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