Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CASC1 (cancer susceptibility 1)

Identity

Alias_namesregulatory subunit 54
Alias_symbol (synonym)LAS1
FLJ10921
PPP1R54
Other alias
HGNC (Hugo) CASC1
LocusID (NCBI) 55259
Atlas_Id 914
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 25108289 and ends at 25195162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CASC1 (12p12.1) / PLEKHA5 (12p12.3)TMTC1 (12p11.22) / CASC1 (12p12.1)CASC1 12p12.1 / PLEKHA5 12p12.3
TMTC1 12p11.22 / CASC1 12p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASC1   29599
Cards
Entrez_Gene (NCBI)CASC1  55259  cancer susceptibility 1
AliasesLAS1; PPP1R54
GeneCards (Weizmann)CASC1
Ensembl hg19 (Hinxton)ENSG00000118307 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118307 [Gene_View]  chr12:25108289-25195162 [Contig_View]  CASC1 [Vega]
ICGC DataPortalENSG00000118307
TCGA cBioPortalCASC1
AceView (NCBI)CASC1
Genatlas (Paris)CASC1
WikiGenes55259
SOURCE (Princeton)CASC1
Genetics Home Reference (NIH)CASC1
Genomic and cartography
GoldenPath hg38 (UCSC)CASC1  -     chr12:25108289-25195162 -  12p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CASC1  -     12p12.1   [Description]    (hg19-Feb_2009)
EnsemblCASC1 - 12p12.1 [CytoView hg19]  CASC1 - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBICASC1 [Mapview hg19]  CASC1 [Mapview hg38]
OMIM616906   
Gene and transcription
Genbank (Entrez)AK001783 AK093102 AK297998 AK301763 AK302235
RefSeq transcript (Entrez)NM_001082972 NM_001082973 NM_001204101 NM_001204102 NM_001319977 NM_001319978 NM_018272
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CASC1
Cluster EST : UnigeneHs.407771 [ NCBI ]
CGAP (NCI)Hs.407771
Alternative Splicing GalleryENSG00000118307
Gene ExpressionCASC1 [ NCBI-GEO ]   CASC1 [ EBI - ARRAY_EXPRESS ]   CASC1 [ SEEK ]   CASC1 [ MEM ]
Gene Expression Viewer (FireBrowse)CASC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55259
GTEX Portal (Tissue expression)CASC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6TDU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6TDU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6TDU7
Splice isoforms : SwissVarQ6TDU7
PhosPhoSitePlusQ6TDU7
Domains : Interpro (EBI)Casc1    Casc1_N   
Domain families : Pfam (Sanger)Casc1_N (PF15927)   
Domain families : Pfam (NCBI)pfam15927   
Conserved Domain (NCBI)CASC1
DMDM Disease mutations55259
Blocks (Seattle)CASC1
SuperfamilyQ6TDU7
Human Protein AtlasENSG00000118307
Peptide AtlasQ6TDU7
HPRD16684
IPIIPI00853432   IPI00853539   IPI00419958   IPI01012303   IPI00935400   IPI01025942   IPI01025361   IPI01025240   IPI01025569   IPI00477405   IPI00783066   
Protein Interaction databases
DIP (DOE-UCLA)Q6TDU7
IntAct (EBI)Q6TDU7
FunCoupENSG00000118307
BioGRIDCASC1
STRING (EMBL)CASC1
ZODIACCASC1
Ontologies - Pathways
QuickGOQ6TDU7
Ontology : AmiGO
Ontology : EGO-EBI
NDEx NetworkCASC1
Atlas of Cancer Signalling NetworkCASC1
Wikipedia pathwaysCASC1
Orthology - Evolution
OrthoDB55259
GeneTree (enSembl)ENSG00000118307
Phylogenetic Trees/Animal Genes : TreeFamCASC1
HOVERGENQ6TDU7
HOGENOMQ6TDU7
Homologs : HomoloGeneCASC1
Homology/Alignments : Family Browser (UCSC)CASC1
Gene fusions - Rearrangements
Fusion : MitelmanCASC1/PLEKHA5 [12p12.1/12p12.3]  
Fusion : MitelmanTMTC1/CASC1 [12p11.22/12p12.1]  [t(12;12)(p11;p12)]  
Fusion: TCGACASC1 12p12.1 PLEKHA5 12p12.3 LUAD
Fusion: TCGATMTC1 12p11.22 CASC1 12p12.1 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASC1
dbVarCASC1
ClinVarCASC1
1000_GenomesCASC1 
Exome Variant ServerCASC1
ExAC (Exome Aggregation Consortium)CASC1 (select the gene name)
Genetic variants : HAPMAP55259
Genomic Variants (DGV)CASC1 [DGVbeta]
DECIPHERCASC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCASC1 
Mutations
ICGC Data PortalCASC1 
TCGA Data PortalCASC1 
Broad Tumor PortalCASC1
OASIS PortalCASC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCASC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASC1
DgiDB (Drug Gene Interaction Database)CASC1
DoCM (Curated mutations)CASC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASC1 (select a term)
intoGenCASC1
Cancer3DCASC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616906   
Orphanet
MedgenCASC1
Genetic Testing Registry CASC1
NextProtQ6TDU7 [Medical]
TSGene55259
GENETestsCASC1
Target ValidationCASC1
Huge Navigator CASC1 [HugePedia]
snp3D : Map Gene to Disease55259
BioCentury BCIQCASC1
ClinGenCASC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55259
Chemical/Pharm GKB GenePA134895953
Clinical trialCASC1
Miscellaneous
canSAR (ICR)CASC1 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASC1
EVEXCASC1
GoPubMedCASC1
iHOPCASC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:26:42 CEST 2017

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