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CASC2 (cancer susceptibility 2)

Identity

Alias (NCBI)C10orf5
HGNC (Hugo) CASC2
HGNC Previous nameC10orf5
HGNC Previous namechromosome 10 open reading frame 5
 cancer susceptibility candidate 2
 cancer susceptibility candidate 2 (non-protein coding)
 cancer susceptibility 2 (non-protein coding)
LocusID (NCBI) 255082
Atlas_Id 915
Location 10q26.11  [Link to chromosome band 10q26]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CASC2   22933
Cards
Entrez_Gene (NCBI)CASC2    cancer susceptibility 2
AliasesC10orf5
GeneCards (Weizmann)CASC2
Ensembl hg19 (Hinxton)ENSG00000177640 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177640 [Gene_View]  ENSG00000177640 [Sequence]  - [Contig_View]  CASC2 [Vega]
ICGC DataPortalENSG00000177640
TCGA cBioPortalCASC2
AceView (NCBI)CASC2
Genatlas (Paris)CASC2
SOURCE (Princeton)CASC2
Genetics Home Reference (NIH)CASC2
Genomic and cartography
GoldenPath hg38 (UCSC)CASC2  -  
GoldenPath hg19 (UCSC)CASC2  -  
GoldenPathCASC2 - [CytoView hg19]  CASC2 - [CytoView hg38]
ImmunoBaseENSG00000177640
Genome Data Viewer NCBICASC2 [Mapview hg19]  
OMIM608598   
Gene and transcription
Genbank (Entrez)AI219353 AJ344228 AJ535620 AJ535621 AJ535622
RefSeq transcript (Entrez)NM_178816 NM_201377
Consensus coding sequences : CCDS (NCBI)CASC2
Gene ExpressionCASC2 [ NCBI-GEO ]   CASC2 [ EBI - ARRAY_EXPRESS ]   CASC2 [ SEEK ]   CASC2 [ MEM ]
Gene Expression Viewer (FireBrowse)CASC2 [ Firebrowse - Broad ]
GenevisibleExpression of CASC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)255082
GTEX Portal (Tissue expression)CASC2
Human Protein AtlasENSG00000177640-CASC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IU53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IU53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IU53
PhosPhoSitePlusQ8IU53
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CASC2
SuperfamilyQ8IU53
AlphaFold pdb e-kbQ8IU53   
Human Protein Atlas [tissue]ENSG00000177640-CASC2 [tissue]
HPRD12266
Protein Interaction databases
DIP (DOE-UCLA)Q8IU53
IntAct (EBI)Q8IU53
BioGRIDCASC2
STRING (EMBL)CASC2
ZODIACCASC2
Ontologies - Pathways
QuickGOQ8IU53
Ontology : AmiGOdefense response to tumor cell  molecular_function  cellular_component  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of MAPK cascade  
Ontology : EGO-EBIdefense response to tumor cell  molecular_function  cellular_component  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of MAPK cascade  
NDEx NetworkCASC2
Atlas of Cancer Signalling NetworkCASC2
Wikipedia pathwaysCASC2
Orthology - Evolution
OrthoDB255082
GeneTree (enSembl)ENSG00000177640
Phylogenetic Trees/Animal Genes : TreeFamCASC2
Homologs : HomoloGeneCASC2
Homology/Alignments : Family Browser (UCSC)CASC2
Gene fusions - Rearrangements
Fusion : QuiverCASC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASC2
dbVarCASC2
ClinVarCASC2
MonarchCASC2
1000_GenomesCASC2 
Exome Variant ServerCASC2
GNOMAD BrowserENSG00000177640
Varsome BrowserCASC2
ACMGCASC2 variants
VarityQ8IU53
Genomic Variants (DGV)CASC2 [DGVbeta]
DECIPHERCASC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCASC2 
Mutations
ICGC Data PortalCASC2 
TCGA Data PortalCASC2 
Broad Tumor PortalCASC2
OASIS PortalCASC2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCASC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCASC2
DgiDB (Drug Gene Interaction Database)CASC2
DoCM (Curated mutations)CASC2
CIViC (Clinical Interpretations of Variants in Cancer)CASC2
Cancer3DCASC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608598   
Orphanet
DisGeNETCASC2
MedgenCASC2
Genetic Testing Registry CASC2
NextProtQ8IU53 [Medical]
GENETestsCASC2
Target ValidationCASC2
Huge Navigator CASC2 [HugePedia]
ClinGenCASC2
Clinical trials, drugs, therapy
MyCancerGenomeCASC2
Protein Interactions : CTDCASC2
Pharm GKB GenePA134938480
PharosQ8IU53
Clinical trialCASC2
Miscellaneous
canSAR (ICR)CASC2
HarmonizomeCASC2
DataMed IndexCASC2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCASC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:02:16 CEST 2021

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