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CASP10 (caspase 10, apoptosis-related cysteine peptidase)

Identity

Other namesALPS2
FLICE2
MCH4
HGNC (Hugo) CASP10
Location 2q33.1
Location_base_pair Starts at 201755866 and ends at 201794628 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CASP10   1500
Entrez_Gene (NCBI)CASP10  843  caspase 10, apoptosis-related cysteine peptidase
Cards
GeneCards (Weizmann)CASP10
Ensembl (Hinxton)ENSG00000003400 [Gene_View]  CASP10 [Vega]
AceView (NCBI)CASP10
Genatlas (Paris)CASP10
euGene (Indiana)843
SOURCE (Stanford)NM_001230 NM_032974 NM_032977
Gene Expression (Array Express) ENSG00000003400
Genomic and cartography
GoldenPath (UCSC)CASP10  -  2q33.1   chr2:201755866-201794628 +  2q33.1   [Description]    (hg18-March_2006)
EnsemblCASP10 - 2q33.1 [CytoView]
Mapping of homologs : NCBICASP10 [Mapview]
OMIM137215   601762   603909   605027   
Gene and transcription
Gene : Genbank (Entrez)AF111344 AF111345 AI696103 AJ487678 AJ487679
Reference sequence (RefSeq transcript) :SRSNM_001230 NM_032974 NM_032977
Reference transcript : EntrezNM_001230 NM_032974 NM_032977
RefSeq genomic : SRSAC_000045 AC_000134 NC_000002 NG_007265 NT_005403 NW_001838863 NW_921618
RefSeq genomic : EntrezAC_000045 AC_000134 NC_000002 NG_007265 NT_005403 NW_001838863 NW_921618
Consensus coding sequences : CCDS NCBICASP10
Cluster EST : UnigeneHs.5353 [ SRS ] Hs.5353 [ NCBI ]
Alternative Splicing : Fast-db (Paris)14314
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ92851 (SRS) Q92851 (Expasy) Q92851 (Uniprot)
With graphics : InterProQ92851
Splice isoforms : VarSplice FASTAQ92851(VarSplice FASTA)
Domaine pattern : Prosite (SRS)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)    DED (PS50168)   
Domain pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)    DED (PS50168)   
Domains : Interpro (SRS)DEATH-like    DED    Pept_C14_cat    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14_p45    Pept_C14_p45_core   
Domains : Interpro (EBI)DEATH-like    DED    Pept_C14_cat    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14_p45    Pept_C14_p45_core   
Related proteins : CluSTrQ92851
Domain families : Pfam SRSDED (PF01335)    Peptidase_C14 (PF00656)   
Domain families : Pfam SangerDED (PF01335)    Peptidase_C14 (PF00656)   
Domain families : Pfam NCBIpfam01335    pfam00656   
Domain families : Smart EMBLCASc (SM00115)  DED (SM00031)  
Blocks (Seattle)Q92851
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD03458
Protein Interaction databases
DIP (DOE-UCLA)Q92851
IntAct (EBI)Q92851
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBICASP10
SNP : GeneSNP UtahCASP10
SNP : HGBaseCASP10
Genetic variants : HAPMAPCASP10
Somatic Mutations in Cancer : COSMICCASP10 
Mutations and Diseases : HGMDCASP10
Hereditary diseases : OMIM137215    601762    603909    605027   
Hereditary diseases : GENETests137215    601762    603909    605027   
Diseases : Genetic AssociationCASP10
General knowledge
Homologs : HomoloGeneCASP10
Homology/Alignments : Family Browser UCSCCASP10
Phylogenetic Trees/Animal Genes : TreeFamCASP10
Catalytic activity : Enzyme3.4.22.63 [ Enzyme-Expasy ]   3.4.22.63 [ Enzyme-SRS ]   3.4.22.63 [ IntEnz-EBI ]   3.4.22.63 [ BRENDA ]   3.4.22.63 [ KEGG ]   
Chemical/Protein Interactions : CTD843
Keywords Ontology : AmiGOcysteine-type endopeptidase activity  proteolysis  peptidase activity  induction of apoptosis by extracellular signals  identical protein binding  regulation of apoptosis  positive regulation of I-kappaB kinase/NF-kappaB cascade  
Keywords Ontology : EGO-EBIcysteine-type endopeptidase activity  proteolysis  peptidase activity  induction of apoptosis by extracellular signals  identical protein binding  regulation of apoptosis  positive regulation of I-kappaB kinase/NF-kappaB cascade  
Pathways : BIOCARTACaspase Cascade in Apoptosis [Genes]    D4-GDI Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    FAS signaling pathway ( CD95 ) [Genes]   
Pathways : KEGGMAPK signaling pathwayApoptosis
Other databases
Probes
Probes : ImagenesCASP10 Related clones (RZPD - Berlin)
Literature
PubMed82 Pubmed reference(s) in Entrez
PubGeneCASP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:42:06 CET 2010
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