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CASP10 (caspase 10)

Identity

Alias_namescaspase 10, apoptosis-related cysteine protease
caspase 10, apoptosis-related cysteine peptidase
Alias_symbol (synonym)MCH4
HGNC (Hugo) CASP10
LocusID (NCBI) 843
Atlas_Id 916
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 202047621 and ends at 202086383 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CASP10 (2q33.1) / CGA (6q14.3)CASP10 (2q33.1) / NUP210 (3p25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Autoimmune lymphoproliferative syndrome


External links

Nomenclature
HGNC (Hugo)CASP10   1500
LRG (Locus Reference Genomic)LRG_33
Cards
Entrez_Gene (NCBI)CASP10  843  caspase 10
AliasesALPS2; FLICE2; MCH4
GeneCards (Weizmann)CASP10
Ensembl hg19 (Hinxton)ENSG00000003400 [Gene_View]  chr2:202047621-202086383 [Contig_View]  CASP10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000003400 [Gene_View]  chr2:202047621-202086383 [Contig_View]  CASP10 [Vega]
ICGC DataPortalENSG00000003400
TCGA cBioPortalCASP10
AceView (NCBI)CASP10
Genatlas (Paris)CASP10
WikiGenes843
SOURCE (Princeton)CASP10
Genetics Home Reference (NIH)CASP10
Genomic and cartography
GoldenPath hg19 (UCSC)CASP10  -     chr2:202047621-202086383 +  2q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP10  -     2q33.1   [Description]    (hg38-Dec_2013)
EnsemblCASP10 - 2q33.1 [CytoView hg19]  CASP10 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBICASP10 [Mapview hg19]  CASP10 [Mapview hg38]
OMIM601762   603909   605027   613659   
Gene and transcription
Genbank (Entrez)AF111344 AF111345 AI696103 AJ487678 AJ487679
RefSeq transcript (Entrez)NM_001206524 NM_001206542 NM_001230 NM_001306083 NM_032974 NM_032976 NM_032977
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CASP10
Cluster EST : UnigeneHs.5353 [ NCBI ]
CGAP (NCI)Hs.5353
Alternative Splicing GalleryENSG00000003400
Gene ExpressionCASP10 [ NCBI-GEO ]   CASP10 [ EBI - ARRAY_EXPRESS ]   CASP10 [ SEEK ]   CASP10 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)843
GTEX Portal (Tissue expression)CASP10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92851   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92851  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92851
Splice isoforms : SwissVarQ92851
Catalytic activity : Enzyme3.4.22.63 [ Enzyme-Expasy ]   3.4.22.633.4.22.63 [ IntEnz-EBI ]   3.4.22.63 [ BRENDA ]   3.4.22.63 [ KEGG ]   
PhosPhoSitePlusQ92851
Domaine pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)    DED (PS50168)   
Domains : Interpro (EBI)Caspase-like_dom    Caspase_cys_AS    Caspase_his_AS    DEATH-like_dom    DED_dom    Pept_C14_p10    Pept_C14_p20    Pept_C14A   
Domain families : Pfam (Sanger)DED (PF01335)   
Domain families : Pfam (NCBI)pfam01335   
Domain families : Smart (EMBL)CASc (SM00115)  DED (SM00031)  
Conserved Domain (NCBI)CASP10
DMDM Disease mutations843
Blocks (Seattle)CASP10
SuperfamilyQ92851
Human Protein AtlasENSG00000003400
Peptide AtlasQ92851
HPRD03458
IPIIPI00290791   IPI00334756   IPI00216197   IPI00868860   IPI00433086   IPI00433087   IPI00470366   
Protein Interaction databases
DIP (DOE-UCLA)Q92851
IntAct (EBI)Q92851
FunCoupENSG00000003400
BioGRIDCASP10
STRING (EMBL)CASP10
ZODIACCASP10
Ontologies - Pathways
QuickGOQ92851
Ontology : AmiGOcysteine-type endopeptidase activity  protein binding  cytosol  proteolysis  apoptotic process  cell surface receptor signaling pathway  extrinsic apoptotic signaling pathway via death domain receptors  macrophage differentiation  CD95 death-inducing signaling complex  ubiquitin protein ligase binding  death effector domain binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  apoptotic signaling pathway  cysteine-type endopeptidase activity involved in apoptotic signaling pathway  ripoptosome  
Ontology : EGO-EBIcysteine-type endopeptidase activity  protein binding  cytosol  proteolysis  apoptotic process  cell surface receptor signaling pathway  extrinsic apoptotic signaling pathway via death domain receptors  macrophage differentiation  CD95 death-inducing signaling complex  ubiquitin protein ligase binding  death effector domain binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  apoptotic signaling pathway  cysteine-type endopeptidase activity involved in apoptotic signaling pathway  ripoptosome  
Pathways : BIOCARTAInduction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    D4-GDI Signaling Pathway [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Caspase Cascade in Apoptosis [Genes]   
Pathways : KEGGApoptosis    RIG-I-like receptor signaling pathway    TNF signaling pathway    Tuberculosis    Hepatitis B   
NDEx NetworkCASP10
Atlas of Cancer Signalling NetworkCASP10
Wikipedia pathwaysCASP10
Orthology - Evolution
OrthoDB843
GeneTree (enSembl)ENSG00000003400
Phylogenetic Trees/Animal Genes : TreeFamCASP10
HOVERGENQ92851
HOGENOMQ92851
Homologs : HomoloGeneCASP10
Homology/Alignments : Family Browser (UCSC)CASP10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP10
dbVarCASP10
ClinVarCASP10
1000_GenomesCASP10 
Exome Variant ServerCASP10
ExAC (Exome Aggregation Consortium)CASP10 (select the gene name)
Genetic variants : HAPMAP843
Genomic Variants (DGV)CASP10 [DGVbeta]
DECIPHER (Syndromes)2:202047621-202086383  ENSG00000003400
CONAN: Copy Number AnalysisCASP10 
Mutations
ICGC Data PortalCASP10 
TCGA Data PortalCASP10 
Broad Tumor PortalCASP10
OASIS PortalCASP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCASP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CASP10
DgiDB (Drug Gene Interaction Database)CASP10
DoCM (Curated mutations)CASP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP10 (select a term)
intoGenCASP10
Cancer3DCASP10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601762    603909    605027    613659   
Orphanet3468   
MedgenCASP10
Genetic Testing Registry CASP10
NextProtQ92851 [Medical]
TSGene843
GENETestsCASP10
Huge Navigator CASP10 [HugePedia]
snp3D : Map Gene to Disease843
BioCentury BCIQCASP10
ClinGenCASP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD843
Chemical/Pharm GKB GenePA26084
Clinical trialCASP10
Miscellaneous
canSAR (ICR)CASP10 (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP10
EVEXCASP10
GoPubMedCASP10
iHOPCASP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 21 15:54:13 CET 2017

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