CASP3 (caspase 3)

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CASP3 (caspase 3)

Identity

Alias (NCBI)	CPP32
	CPP32B
	SCA-1
HGNC (Hugo)	CASP3
HGNC Alias symb	CPP32
	CPP32B
	Yama
	apopain
HGNC Previous name	caspase 3, apoptosis-related cysteine protease
	caspase 3, apoptosis-related cysteine peptidase
LocusID (NCBI)	836
Atlas_Id	920
Location	4q35.1 [Link to chromosome band 4q35]
Location_base_pair	Starts at 184627696 and ends at 184649475 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CASP3 1504
	Cards
Entrez_Gene (NCBI)	CASP3 caspase 3
Aliases	CPP32; CPP32B; SCA-1
GeneCards (Weizmann)	CASP3
Ensembl hg19 (Hinxton)	ENSG00000164305 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000164305 [Gene_View] ENSG00000164305 [Sequence] chr4:184627696-184649475 [Contig_View] CASP3 [Vega]
ICGC DataPortal	ENSG00000164305
TCGA cBioPortal	CASP3
AceView (NCBI)	CASP3
Genatlas (Paris)	CASP3
SOURCE (Princeton)	CASP3
Genetics Home Reference (NIH)	CASP3
	Genomic and cartography
GoldenPath hg38 (UCSC)	CASP3 - chr4:184627696-184649475 - 4q35.1 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	CASP3 - 4q35.1 [Description] (hg19-Feb_2009)
GoldenPath	CASP3 - 4q35.1 [CytoView hg19] CASP3 - 4q35.1 [CytoView hg38]
ImmunoBase	ENSG00000164305
genome Data Viewer NCBI	CASP3 [Mapview hg19]
OMIM	600636
	Gene and transcription
Genbank (Entrez)	AJ413269 AK291337 AU127028 AU133051 BC016926
RefSeq transcript (Entrez)	NM_001354777 NM_001354779 NM_001354780 NM_001354781 NM_001354782 NM_001354783 NM_001354784 NM_004346 NM_032991
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	CASP3
Alternative Splicing Gallery	ENSG00000164305
Gene Expression	CASP3 [ NCBI-GEO ] CASP3 [ EBI - ARRAY_EXPRESS ] CASP3 [ SEEK ] CASP3 [ MEM ]
Gene Expression Viewer (FireBrowse)	CASP3 [ Firebrowse - Broad ]
Genevisible	Expression of CASP3 in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	836
GTEX Portal (Tissue expression)	CASP3
Human Protein Atlas	ENSG00000164305-CASP3 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P42574 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P42574 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P42574
Splice isoforms : SwissVar	P42574
Catalytic activity : Enzyme	3.4.22.56 [ Enzyme-Expasy ] 3.4.22.56 3.4.22.56 [ IntEnz-EBI ] 3.4.22.56 [ BRENDA ] 3.4.22.56 [ KEGG ] [ MEROPS ]
PhosPhoSitePlus	P42574
Domaine pattern : Prosite (Expaxy)	CASPASE_CYS (PS01122) CASPASE_HIS (PS01121) CASPASE_P10 (PS50207) CASPASE_P20 (PS50208)
Domains : Interpro (EBI)	Caspase-like_dom_sf Caspase_cys_AS Caspase_his_AS Pept_C14 Pept_C14_p10 Pept_C14_p20 Pept_C14A
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)	CASc (SM00115)
Conserved Domain (NCBI)	CASP3
Blocks (Seattle)	CASP3
PDB (RSDB)	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
PDB Europe	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
PDB (PDBSum)	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
PDB (IMB)	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
Structural Biology KnowledgeBase	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
SCOP (Structural Classification of Proteins)	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
CATH (Classification of proteins structures)	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
Superfamily	P42574
Human Protein Atlas [tissue]	ENSG00000164305-CASP3 [tissue]
Peptide Atlas	P42574
HPRD	02799
IPI	IPI00292140 IPI00553172 IPI00798166
	Protein Interaction databases
DIP (DOE-UCLA)	P42574
IntAct (EBI)	P42574
BioGRID	CASP3
STRING (EMBL)	CASP3
ZODIAC	CASP3
	Ontologies - Pathways
QuickGO	P42574
Ontology : AmiGO	luteolysis response to hypoxia B cell homeostasis protease binding aspartic-type endopeptidase activity cysteine-type endopeptidase activity cyclin-dependent protein serine/threonine kinase inhibitor activity death receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol cytosol apoptotic DNA fragmentation proteolysis apoptotic process apoptotic process cellular response to DNA damage stimulus axonal fasciculation heart development sensory perception of sound learning or memory peptidase activity intrinsic apoptotic signaling pathway in response to osmotic stress response to UV response to glucose response to X-ray phospholipase A2 activator activity regulation of macroautophagy protein processing cytokine-mediated signaling pathway hippocampus development neuron differentiation keratinocyte differentiation erythrocyte differentiation erythrocyte differentiation erythrocyte differentiation platelet formation negative regulation of B cell proliferation death-inducing signaling complex regulation of protein stability response to cobalt ion response to estradiol response to lipopolysaccharide glial cell apoptotic process response to tumor necrosis factor response to nicotine hippo signaling wound healing response to hydrogen peroxide neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity response to amino acid positive regulation of neuron apoptotic process protein-containing complex binding membrane raft cell fate commitment negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of activated T cell proliferation neurotrophin TRK receptor signaling pathway striated muscle cell differentiation response to glucocorticoid neuron apoptotic process anterior neural tube closure leukocyte apoptotic process cellular response to staurosporine cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand execution phase of apoptosis execution phase of apoptosis execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of amyloid-beta formation
Ontology : EGO-EBI	luteolysis response to hypoxia B cell homeostasis protease binding aspartic-type endopeptidase activity cysteine-type endopeptidase activity cyclin-dependent protein serine/threonine kinase inhibitor activity death receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol cytosol apoptotic DNA fragmentation proteolysis apoptotic process apoptotic process cellular response to DNA damage stimulus axonal fasciculation heart development sensory perception of sound learning or memory peptidase activity intrinsic apoptotic signaling pathway in response to osmotic stress response to UV response to glucose response to X-ray phospholipase A2 activator activity regulation of macroautophagy protein processing cytokine-mediated signaling pathway hippocampus development neuron differentiation keratinocyte differentiation erythrocyte differentiation erythrocyte differentiation erythrocyte differentiation platelet formation negative regulation of B cell proliferation death-inducing signaling complex regulation of protein stability response to cobalt ion response to estradiol response to lipopolysaccharide glial cell apoptotic process response to tumor necrosis factor response to nicotine hippo signaling wound healing response to hydrogen peroxide neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity response to amino acid positive regulation of neuron apoptotic process protein-containing complex binding membrane raft cell fate commitment negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of activated T cell proliferation neurotrophin TRK receptor signaling pathway striated muscle cell differentiation response to glucocorticoid neuron apoptotic process anterior neural tube closure leukocyte apoptotic process cellular response to staurosporine cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand execution phase of apoptosis execution phase of apoptosis execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of amyloid-beta formation
Pathways : KEGG	MAPK signaling pathway p53 signaling pathway Apoptosis Natural killer cell mediated cytotoxicity TNF signaling pathway Serotonergic synapse Non-alcoholic fatty liver disease (NAFLD) Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis (ALS) Huntington's disease Epithelial cell signaling in Helicobacter pylori infection Pertussis Legionellosis Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Herpes simplex infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Viral myocarditis
NDEx Network	CASP3
Atlas of Cancer Signalling Network	CASP3
Wikipedia pathways	CASP3
	Orthology - Evolution
OrthoDB	836
GeneTree (enSembl)	ENSG00000164305
Phylogenetic Trees/Animal Genes : TreeFam	CASP3
HOGENOM	P42574
Homologs : HomoloGene	CASP3
Homology/Alignments : Family Browser (UCSC)	CASP3
	Gene fusions - Rearrangements
Fusion : Quiver	CASP3
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	CASP3 [hg38]
dbVar	CASP3
ClinVar	CASP3
Monarch	CASP3
1000_Genomes	CASP3
Exome Variant Server	CASP3
GNOMAD Browser	ENSG00000164305
Varsome Browser	CASP3
Genomic Variants (DGV)	CASP3 [DGVbeta]
DECIPHER	CASP3 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	CASP3
	Mutations
ICGC Data Portal	CASP3
TCGA Data Portal	CASP3
Broad Tumor Portal	CASP3
OASIS Portal	CASP3 [ Somatic mutations - Copy number]
Cancer Gene: Census	CASP3
Somatic Mutations in Cancer : COSMIC	CASP3 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	CASP3
Mutations and Diseases : HGMD	CASP3
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search CASP3
DgiDB (Drug Gene Interaction Database)	CASP3
DoCM (Curated mutations)	CASP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	CASP3 (select a term)
intoGen	CASP3
Cancer3D	CASP3(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	600636
Orphanet
DisGeNET	CASP3
Medgen	CASP3
Genetic Testing Registry	CASP3
NextProt	P42574 [Medical]
GENETests	CASP3
Target Validation	CASP3
Huge Navigator	CASP3 [HugePedia]
ClinGen	CASP3
	Clinical trials, drugs, therapy
MyCancerGenome	CASP3
Protein Interactions : CTD
Pharm GKB Gene	PA26087
Pharm GKB Pathways	PA152241951 PA166115250
Pharos	P42574
Clinical trial	CASP3
	Miscellaneous
canSAR (ICR)	CASP3 (select the gene name)
Harmonizome	CASP3
DataMed Index	CASP3
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
EVEX	CASP3

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Fri Jan 1 18:08:24 CET 2021

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

CASP3 (caspase 3)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute